#include #include "mmpriv.h" #include "kalloc.h" void mm_select_sub_multi(void *km, float pri_ratio, float pri1, float pri2, int max_gap_ref, int min_diff, int best_n, int n_segs, const int *qlens, int *n_, mm_reg1_t *r) { if (pri_ratio > 0.0f && *n_ > 0) { int i, k, n = *n_, n_2nd = 0; int max_dist = n_segs == 2? qlens[0] + qlens[1] + max_gap_ref : 0; for (i = k = 0; i < n; ++i) { int to_keep = 0; if (r[i].parent == i) { // primary to_keep = 1; } else if (r[i].score + min_diff >= r[r[i].parent].score) { to_keep = 1; } else { mm_reg1_t *p = &r[r[i].parent], *q = &r[i]; if (p->rev == q->rev && p->rid == q->rid && q->re - p->rs < max_dist && p->re - q->rs < max_dist) { // child and parent are close on the ref if (q->score >= p->score * pri1) to_keep = 1; } else { int is_par_both = (n_segs == 2 && p->qs < qlens[0] && p->qe > qlens[0]); int is_chi_both = (n_segs == 2 && q->qs < qlens[0] && q->qe > qlens[0]); if (is_chi_both || is_chi_both == is_par_both) { if (q->score >= p->score * pri_ratio) to_keep = 1; } else { // the remaining case: is_chi_both == 0 && is_par_both == 1 if (q->score >= p->score * pri2) to_keep = 1; } } } if (to_keep && r[i].parent != i) { if (n_2nd++ >= best_n) to_keep = 0; // don't keep if there are too many secondary hits } if (to_keep) r[k++] = r[i]; else if (r[i].p) free(r[i].p); } if (k != n) mm_sync_regs(km, k, r); // removing hits requires sync() *n_ = k; } } #include "ksort.h" typedef struct { int s, rev; uint64_t key; mm_reg1_t *r; } pair_arr_t; #define sort_key_pair(a) ((a).key) KRADIX_SORT_INIT(pair, pair_arr_t, sort_key_pair, 8) void mm_pair(void *km, int max_gap_ref, int pe_bonus, const int *qlens, int *n_regs, mm_reg1_t **regs) { int i, j, s, n, last[2], dp_thres, segs = 0, n_pairs = 0, max_idx[2]; int64_t max, max2; pair_arr_t *a; a = (pair_arr_t*)kmalloc(km, (n_regs[0] + n_regs[1]) * sizeof(pair_arr_t)); for (s = n = 0, dp_thres = 0; s < 2; ++s) { int max = 0; for (i = 0; i < n_regs[s]; ++i) { a[n].s = s; a[n].r = ®s[s][i]; a[n].rev = a[n].r->rev; a[n].key = (uint64_t)a[n].r->rid << 32 | a[n].r->rs<<1 | (s^a[n].rev); max = max > a[n].r->p->dp_max? max : a[n].r->p->dp_max; ++n; segs |= 1<rid != q->rid || r->rs - q->re > max_gap_ref) continue; for (j = last[a[i].rev]; j >= 0; --j) { int sum; if (a[j].rev != a[i].rev || a[j].s == a[i].s) continue; q = a[j].r; if (r->rid != q->rid || r->rs - q->re > max_gap_ref) break; if (r->p->dp_max + q->p->dp_max < dp_thres) continue; ++n_pairs; sum = r->p->dp_max + q->p->dp_max; if (sum > max) { max_idx[a[j].s] = j, max_idx[a[i].s] = i; max2 = max; max = sum; } else if (sum > max2) max2 = sum; } } else { // forward first read or reverse second read last[a[i].rev] = i; } } if (max > 0) { for (s = 0; s < 2; ++s) { mm_reg1_t *r = a[max_idx[s]].r; if (r->id != r->parent) { mm_reg1_t *p = ®s[s][r->parent]; for (i = 0; i < n_regs[s]; ++i) if (regs[s][i].parent == p->id) regs[s][i].parent = r->id; } } } kfree(km, a); }