Commit Graph

590 Commits (f6608fe99c1ea5ebe2eeedba8d8c21e33f5fac86)

Author SHA1 Message Date
Heng Li f6608fe99c r620: revamped thread-local memory management
* Don't preallocate sdust_buf or minizer list. kalloc should be fast enough -
  benchmarks needed to confirm.

* Fixed a memory leak caused by divergence estimate (post v2.5)

* Reset the kalloc buffer after mapping a long query. This reduces peak memory
  when large chunks of memory are allocated, at the cost of performance, though.
2017-12-11 12:11:10 -05:00
Heng Li 98a6e52c06 r618: heuristics to avoid tiny terminal exons 2017-12-11 00:57:55 -05:00
Heng Li 824712a4ee r617: removed some unused code 2017-12-10 17:54:50 -05:00
Heng Li 0e42628ef6 r611: document --idx-no-seq; better inv aln 2017-12-08 13:16:18 -05:00
Heng Li 98a999fe44 r611: added pseudocount when est divergence 2017-12-08 12:57:57 -05:00
Heng Li fec7bd713f r610: warning if db sequence is 0-lengthed (#69) 2017-12-07 21:05:39 -05:00
Heng Li 2f693e8ca4 r609: bugfix - SDUST masking not working 2017-12-07 11:45:38 -05:00
Heng Li 704ff9f4c6 r607: estimate sequence divergence
Currently using the simplest method. There may be a more accurate estimate.
2017-12-06 16:14:39 -05:00
Heng Li 68c63f2d68 r606: fixed a sketch bug for long 256bp k-mer
sketch() writes {-1,-1} to the output array.
2017-12-06 16:13:29 -05:00
Heng Li 76206f574f support both SAM and PAF as input 2017-12-02 21:57:19 -05:00
Heng Li e575f884e1 convert spliced PAF to BED 2017-12-02 21:23:41 -05:00
Heng Li 571161d5a2 changed badges 2017-12-01 16:16:27 -05:00
Heng Li 07d41efc2b explain secondary/supplementary aln for RNA-seq 2017-11-30 23:02:20 -05:00
Heng Li 984f7846c0 r601: bugfix - a similar issue to r600
This bug unsets the alignment score of suboptimal alignments.
2017-11-30 11:51:34 -05:00
Heng Li af1d6afba9 r600: bugfix - missing secondary alignments (#71)
This should very rarely happen to typical data, but has a higher chance in
artifactual data.
2017-11-30 11:34:10 -05:00
Heng Li cbdb6c069f when there are incorrect anno, warn but not abort 2017-11-24 12:48:49 -05:00
Heng Li 35b6d9f7d5 direct manpage to HTML 2017-11-24 11:05:20 -05:00
Heng Li 39a9666246 convert PAF to LAST's cigar output
also added the support of BLAST-like output for "--cs=short".
2017-11-18 20:30:44 -05:00
Heng Li 662d05dc02 fixed incorrect var coordinate 2017-11-12 20:25:33 -05:00
Heng Li 379457c18b use mapq threshold 2017-11-12 19:01:34 -05:00
Heng Li 03169d590b print cov-1 regions (not BED output any more) 2017-11-12 18:45:49 -05:00
Heng Li 8c8d446820 find regions covered by one contig 2017-11-12 18:41:01 -05:00
Heng Li 0ddb064f17 dnadiff-like script; improvement coming 2017-11-12 15:07:29 -05:00
Heng Li 131cfc6938 r574: build index without sequences 2017-11-11 21:38:38 -05:00
Heng Li 2f463b1db0 r573: prepare to generalize index 2017-11-11 19:54:06 -05:00
Heng Li 3b518271ee Release minimap2-2.5 (r572) 2017-11-11 11:29:28 -05:00
Heng Li 481d8239e9
Merge pull request #57 from cjw85/strand_typo
Fix typo in strand property
2017-11-10 20:36:19 -05:00
cwright 4f77b0c1ed Fix typo in strand property 2017-11-11 01:18:44 +00:00
Heng Li d7a31e40e6 r569: last commit is buggy 2017-11-09 23:20:41 -05:00
Heng Li dd18cd75de r568: revert - don't take max(dp_max, dp_score) 2017-11-09 23:12:48 -05:00
Heng Li 99a2709913 r567: minor change to #56 2017-11-09 19:17:45 -05:00
Heng Li 032068a747
Merge pull request #56 from mvdbeek/softclipping
Implement -Y for soft clipping of supp. alignments
2017-11-09 19:12:47 -05:00
mvdbeek 1cb0bf4bef Implement -Y for soft clipping of supp. alignments
I tried to base this on bwa-mem and it seems to work for sam alignments.
2017-11-09 19:22:36 +01:00
Heng Li 422b43374e
Merge pull request #55 from martinghunt/fix_python3_strings
Bug fix with byte strings in Python3
2017-11-09 09:37:41 -05:00
martinghunt 29a26e3eea Bug fix with byte strings in Python3 2017-11-09 13:57:15 +00:00
Heng Li a7b38f6900 r562: fixed a severe bug: wrong query start 2017-11-08 22:31:05 -05:00
Heng Li e896c9ec05 r559: prefer a chain involving more segments 2017-11-08 13:22:16 -05:00
Heng Li 98ba8928c6 r558: dp_max no less than dp_score 2017-11-08 10:06:10 -05:00
Heng Li bcf8462d20
Merge pull request #52 from cvdelannoy/patch-1
Update README.md
2017-11-08 07:50:31 -05:00
Carlos de Lannoy c047c852ce
Update README.md
25: changed -x ava-one to -x ava-ont
2017-11-08 13:07:01 +01:00
Heng Li b24d68ae9f r557: fixed another mapq underestimate
When a chain is split during base-level alignment, its chaining score is
reduced. However, the chaining score of its suboptimal chain remains the same.
This leads to underestimated mapping quality.
2017-11-07 23:20:49 -05:00
Heng Li 65deedfa96 r556: bugfix - underestimate mapq for split aln 2017-11-07 22:37:12 -05:00
Heng Li 21a46ba652 Release minimap2-2.4 (r555) 2017-11-06 12:54:02 -05:00
Heng Li 1617b87ee1 this will become version 3 at arXiv 2017-11-06 10:57:12 -05:00
Heng Li 2191ac58ad two discussion paragraphs; need one more 2017-11-05 12:27:52 -05:00
Heng Li fa5a645ca5 r552: fixed a tiny typo on struct packing
The old packing wastes memory, thought very small.
2017-11-05 08:27:26 -05:00
Heng Li c2b09356b8 moved conclusion to result; need new discussion 2017-11-04 22:19:46 -04:00
Heng Li a3f0aa1d5b r550: fixed -L issues with secondary and supp aln 2017-11-04 12:13:38 -04:00
Heng Li 52ffbc9e0c added bowtie2 and snap versions 2017-11-02 15:51:23 -04:00
Heng Li a9790c0f1d added two bowtie2 numbers for comparison 2017-11-02 15:44:48 -04:00