0f7455cefa
r365: documented the "sr" preset
2017-09-14 12:57:21 -04:00
d7f2ac1d4f
better parameters for short reads
...
It turns out the key problem is not the minimizer density. It is the max
occurrence that tends to affect results more, especially sensitivity. There is
still lots of work to do, but for now, it seems a good start.
2017-09-12 16:11:23 -04:00
eccdb3a1ca
r315: added getopt from musl
2017-09-01 20:20:34 +08:00
0fe1a224ab
r309: improved SAM header output
2017-08-25 10:35:58 +08:00
993a2bb521
r301: separate introns from deletions
...
When an intron is adjacent to a deletion, the old code count both as introns,
which lead to an inaccurate exon boundary.
2017-08-18 15:31:15 +08:00
2cde8d257c
r297: bidirectional RNA alignment
2017-08-17 06:02:44 -04:00
b5f5929bf9
r296: expose splicing related options to CLI
2017-08-13 21:37:51 -04:00
28f86688ab
r295: gap closure from the middle of non-HPC k
...
This WILL slightly affect the result of genomic mapping, but hopefully
in the good direction.
2017-08-12 23:48:43 -04:00
43506edbc5
backup: preliminary boundary alignment
2017-08-12 23:10:14 -04:00
61eef0575c
separate out spliced alignment; not right yet
2017-08-12 18:54:32 -04:00
d240318741
r287: refined CLI options and manpage
2017-08-12 12:26:04 -04:00
0f4c823b0c
r286: ignore introns when computing max seg score
2017-08-12 10:58:16 -04:00
163fa36ee6
r281: don't open long gaps on query
2017-08-10 15:04:59 -04:00
1a7d782131
r273: cdna mapping mode for testing
...
Differences from the typical mapping mode:
* banded alignment disabled
* log gap cost during chaining
* zero long-gap extension during alignment
* up to 100kb (by default) reference gap
* bad seeding not filtered (to tune later)
2017-08-08 11:31:49 -04:00
5934d68772
r229: a new way to prevent out-of-band backtrack
2017-07-29 23:52:30 -04:00
fa99d28d34
r228: reduced unnecessary INV alignment
2017-07-29 20:21:53 -04:00
d08b7a0c51
r227: use local alignment for INV alignment
2017-07-29 17:40:53 -04:00
da3db3c095
r226: only try inv alignment for primary
2017-07-29 14:09:35 -04:00
783ead6f47
r225: removed a debugging line
2017-07-29 13:21:38 -04:00
19d6ec885e
r224: inversion alignment around Z-drop break
2017-07-29 13:09:10 -04:00
120bebc290
ake
2017-07-29 11:01:49 -04:00
5e3eecd6d4
r222: no effective changes
2017-07-29 10:31:46 -04:00
ebbe9c1eb8
r219: fixed a bug caused by skipping tandem seeds
2017-07-28 14:06:56 -04:00
c672690564
r218: increase the frequency of SW slightly
2017-07-28 13:30:42 -04:00
f4fee60188
r217: ignore tandem seeds during alignment
...
This helps a tiny bit.
2017-07-28 12:26:56 -04:00
254280b8af
r216: a bit cleanup; identical output to r215
2017-07-28 11:54:18 -04:00
2c79580649
r213: more careful solution to wrong seeds
...
a little better, but not good enough!
2017-07-27 13:19:11 -04:00
b927838495
r212: better heuristic to fix wrong seeding
...
but not good enough. Will explore more.
2017-07-27 11:24:51 -04:00
371e20cc7c
r211: a better heurstic to reduce false seeds
2017-07-26 23:56:38 -04:00
f2ef48878a
r202: trim bad chain ends before extension
...
This fixes a few more FP long INDELs towards the end of alignments.
2017-07-25 19:53:19 -04:00
38b2830e18
r161: filter bad seeds; changed default -g/-r
2017-07-08 13:31:27 -04:00
cc554aee43
r159: use two-piece gap penalty
2017-07-08 10:26:00 -04:00
2e4fd9f1d0
r148: revamped regs handling after cigar
2017-07-03 10:44:26 -04:00
696ebce66e
backup; still buggy
2017-07-03 00:52:00 -04:00
426c2975f6
r126: filter by fraction of seed coverage
...
otherwise we may get too many poor overlap mappings.
2017-06-30 22:15:45 -04:00
d11049eb32
r120: use max-scoring seg to control output
...
much better now
2017-06-30 14:21:44 -04:00
5dcd8f8965
r117: fixed a bug in logic
2017-06-30 11:52:42 -04:00
91e1c4d6db
r116: fixed another bug caused by refactoring
2017-06-30 00:03:45 -04:00
e2b86d0332
r110: fixed a bug caused by refactoring
2017-06-29 21:12:31 -04:00
4cd456b9ba
r108: refactoring, move reg1 routines to hit.c
2017-06-29 19:44:11 -04:00
cc67f1b781
compute mapq; not working for z-split yet
2017-06-29 17:52:48 -04:00
337c2a21cd
r105: fixed a bug in repeated right ext when zdrop
2017-06-29 15:45:07 -04:00
b9075d39a8
r104: long gap patching
2017-06-29 14:54:54 -04:00
d274e1b743
backup
2017-06-29 12:58:52 -04:00
38070e8a05
r98: fixed segfault for certain scoring
...
due to unsigned comparisons between -1 and chromosome length
2017-06-28 22:18:51 -04:00
bcd9b1c621
r93: fixed various small issues
2017-06-28 10:35:21 -04:00
42283ef10c
r87: fixed a bug in ksw2
2017-06-27 13:29:48 -04:00
734028f92b
validate z-drop
2017-06-27 11:25:39 -04:00
c02ff4662c
r85: two-round z-drop
2017-06-27 10:36:24 -04:00
5b614ae828
r78: fixed a split bug
2017-06-26 14:45:23 -04:00
Heng Li