diff --git a/README.md b/README.md index b375278..0d40147 100644 --- a/README.md +++ b/README.md @@ -12,7 +12,7 @@ cd minimap2 && make ./minimap2 -x map-ont -d MT-human-ont.mmi test/MT-human.fa ./minimap2 -a MT-human-ont.mmi test/MT-orang.fa > test.sam # use presets (no test data) -./minimap2 -ax map-pb ref.fa pacbio.fq.gz > aln.sam # PacBio genomic reads +./minimap2 -ax map-pb ref.fa pacbio.fq.gz > aln.sam # PacBio CLR genomic reads ./minimap2 -ax map-ont ref.fa ont.fq.gz > aln.sam # Oxford Nanopore genomic reads ./minimap2 -ax map-hifi ref.fa pacbio-ccs.fq.gz > aln.sam # PacBio HiFi/CCS genomic reads ./minimap2 -ax sr ref.fa read1.fa read2.fa > aln.sam # short genomic paired-end reads @@ -139,13 +139,13 @@ parameters at the same time. The default setting is the same as `map-ont`. #### Map long noisy genomic reads ```sh -minimap2 -ax map-pb ref.fa pacbio-reads.fq > aln.sam # for PacBio subreads +minimap2 -ax map-pb ref.fa pacbio-reads.fq > aln.sam # for PacBio CLR reads minimap2 -ax map-ont ref.fa ont-reads.fq > aln.sam # for Oxford Nanopore reads ``` The difference between `map-pb` and `map-ont` is that `map-pb` uses homopolymer-compressed (HPC) minimizers as seeds, while `map-ont` uses ordinary minimizers as seeds. Emperical evaluation suggests HPC minimizers improve -performance and sensitivity when aligning PacBio reads, but hurt when aligning +performance and sensitivity when aligning PacBio CLR reads, but hurt when aligning Nanopore reads. #### Map long mRNA/cDNA reads @@ -206,7 +206,7 @@ strand field. In this case, each line indicates an oriented junction. #### Find overlaps between long reads ```sh -minimap2 -x ava-pb reads.fq reads.fq > ovlp.paf # PacBio read overlap +minimap2 -x ava-pb reads.fq reads.fq > ovlp.paf # PacBio CLR read overlap minimap2 -x ava-ont reads.fq reads.fq > ovlp.paf # Oxford Nanopore read overlap ``` Similarly, `ava-pb` uses HPC minimizers while `ava-ont` uses ordinary