diff --git a/minimap2.1 b/minimap2.1 index 919e158..5e95fbb 100644 --- a/minimap2.1 +++ b/minimap2.1 @@ -275,6 +275,15 @@ nn i Number of ambiguous bases in the alignment cg Z CIGAR string (only in PAF) .TE +.SH LIMITATIONS +.PP +At the alignment phase, minimap2 performs global alignments between minimizer +hits. If the positions of these minimizer hits are incorrect, the final alignment +may be suboptimal or broken due to the Z-drop heuristics. In addition, in the +event of a long insertion/deletion, minimap2 may split the long event into +a few smaller events. We will address these issues in future. +.PP +Minimap2 does not work well with Illumina short reads as of now. .SH SEE ALSO .PP miniasm(1), minimap(1), bwa(1).