diff --git a/FAQ.md b/FAQ.md
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+++ b/FAQ.md
@@ -0,0 +1,46 @@
+#### 1. Alignment different with option `-a` or `-c`?
+
+Without `-a`, `-c` or `--cs`, minimap2 only finds *approximate* mapping
+locations without detailed base alignment. In particular, the start and end
+positions of the alignment are impricise. With one of those options, minimap2
+will perform base alignment, which is generally more accurate but is much
+slower.
+
+#### 2. How to map Illumina short reads to noisy long reads?
+
+No good solutions. The better approach is to assemble short reads into contigs
+and then map noisy reads to contigs.
+
+#### 3. The output SAM doesn't have a header.
+
+By default, minimap2 indexes 4 billion reference bases (4Gb) in a batch and map
+all reads against each reference batch. Given a reference longer than 4Gb,
+minimap2 is unable to see all the sequences and thus can't produce a correct
+SAM header. In this case, minimap2 doesn't output any SAM header. There are two
+solutions to this issue. First, you may increase option `-I` to, for example,
+`-I8g` to index more reference bases in a batch. This is preferred if your
+machine has enough memory. Second, if your machines doesn't have enough memory
+to hold the reference index, you can use the `--split-prefix` option in a
+command line like:
+```sh
+minimap2 -ax map-ont --split-prefix=tmp ref.fa reads.fq
+```
+This second approach uses less memory, but it is slower and requires temporary
+disk space.
+
+#### 4. The output SAM is malformatted.
+
+This typically happens when you use nohup to wrap a minimap2 command line.
+Nohup is discouraged as it breaks piping. If you have to use nohup, please
+specify an output file with option `-o`.
+
+#### 5. How to output one alignment per read?
+
+You can use `--secondary=no` to suppress secondary alignments (aka multiple
+mappings), but you can't suppress supplementary alignment (aka split or
+chimeric alignment) this way. You can use samtools to filter out these
+alignments:
+```sh
+minimap2 -ax map-out ref.fa reads.fq | samtools view -F0x900
+```
+However, this is discouraged as supplementary alignment is informative.
diff --git a/README.md b/README.md
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--- a/README.md
+++ b/README.md
@@ -315,9 +315,10 @@ highlighted in bold. The description may help to tune minimap2 parameters.
 ### <a name="help"></a>Getting help
 
 Manpage [minimap2.1][manpage] provides detailed description of minimap2
-command line options and optional tags. If you encounter bugs or have further
-questions or requests, you can raise an issue at the [issue page][issue].
-There is not a specific mailing list for the time being.
+command line options and optional tags. The [FAQ](FAQ.md) page answers several
+frequently asked questions. If you encounter bugs or have further questions or
+requests, you can raise an issue at the [issue page][issue].  There is not a
+specific mailing list for the time being.
 
 ### <a name="cite"></a>Citing minimap2