Eric Banks ef95757311 Fix MD5 because of a need to fix a busted bam file in our validation directory (it used the wrong quality score encoding...)		2012-12-03 21:46:46 -05:00
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gatk/walkers	Fix MD5 because of a need to fix a busted bam file in our validation directory (it used the wrong quality score encoding...)	2012-12-03 21:46:46 -05:00
utils/pairhmm	Refactoring the PairHMM util class to allow for multiple implementations which can be specified by the callers via an enum argument. Adding an optimized PairHMM implementation which caches per-read calculations as well as a logless implementation which drastically reduces the runtime of the HMM while also increasing the precision of the result. In the HaplotypeCaller we now lexicographically sort the haplotypes to take maximal benefit of the haplotype offset optimization which only recalculates the HMM matrices after the first differing base in the haplotype. Many thanks to Mauricio for all the initial groundwork for these optimizations. The change to the one HC integration test is in the fourth decimal of HaplotypeScore.	2012-10-20 16:38:18 -04:00