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David Roazen e82946e5c9 ExperimentalReadShardBalancer: create one monolithic FilePointer per contig
Merge all FilePointers for each contig into a single, merged, optimized FilePointer
representing all regions to visit in all BAM files for a given contig.

This helps us in several ways:

-It allows us to create a single, persistent set of iterators for each contig,
 finally and definitively eliminating all Shard/FilePointer boundary issues for
 the new experimental ReadWalker downsampling

-We no longer need to track low-level file positions in the sharding system (which
 was no longer possible anyway given the new experimental downsampling system)

-We no longer revisit BAM file chunks that we've visited in the past -- all BAM
 file access is purely sequential

-We no longer need to constantly recreate our full chain of read iterators

There are also potential dangers:

-We hold more BAM index data in memory at once. Given that we merge and optimize
 the index data during the merge, and only hold one contig's worth of data at a
 time, this does not appear to be a major issue. TODO: confirm this!

-With a huge number of samples and intervals, the FilePointer merge operation
 might become expensive. With the latest implementation, this does not
 appear to be an issue even with a huge number of intervals (for one sample, at least),
 but if it turns out to be a problem for > 1 sample there are things we can do.

Still TODO: unit tests for the new FilePointer.union() method
2012-09-27 14:47:54 -04:00
licensing Revert unintentional license change 2012-08-09 17:10:47 -04:00
protected/java RR bug: when determining the most common base at a position, break ties by which base has the highest sum of base qualities. Otherwise, sites with 1 Q2 N and 1 Q30 C are ending up as Ns in the consensus. I think perhaps we don't even care about which base has the most observations - it should just be determined by which has the highest sum of base qualities - but I'm not sure that's what users would expect. 2012-09-24 21:46:14 -04:00
public ExperimentalReadShardBalancer: create one monolithic FilePointer per contig 2012-09-27 14:47:54 -04:00
settings Updating cofoja to the latest version 2012-08-09 16:36:18 -04:00
.gitignore a few more useful git ignores 2012-09-01 11:08:36 -04:00
build.xml Proper error handling in NanoScheduler 2012-09-19 17:03:13 -04:00
ivy.xml Updating cofoja to the latest version 2012-08-09 16:36:18 -04:00