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kiran bd27287fe7 An R module that takes in a Variant Recalibration cluster file (file with '@!CLUSTER' lines in it), a tabularized VCF, and optionally a set of loci that should be examined more carefully, and emits a tremendous number of plots. For every annotation used in clustering, the distributions and pair-wise comparison (with ellipses denoting the 2-sigma cluster boundaries) are shown. Each cluster is shaded with a color proportional to its mixture coefficient.
To use this module, you'll first have to take your VCF and create an R-readable table out of it with the following command:

python /path/to/Sting/trunk/python/vcf2table.py -f CHROM,POS,ID,AC,AF,AN,DB,DP,HRun,MQ,MQ0,MyHaplotypeScore,QD,SB my.vcf > my.vcf.table

Then, simply invoke this module with the command:

Rscript /path/to/Sting/trunk/R/VariantRecalibratorReport/VariantRecalibratorReport.R /path/to/output/prefix /path/to/my/my.clusters /path/to/my.vcf.table [/path/to/my.suspicious.loci]

This will create a number of plots all with the prefix "/path/to/output/prefix".  For instance, if you used QD, SB, HRun, and MyHaplotypeScore annotations during clustering, you should see output like this:

    /path/to/output/prefix.anndist.HRun.pdf
    /path/to/output/prefix.anndist.MyHaplotypeScore.pdf
    /path/to/output/prefix.anndist.QD.pdf
    /path/to/output/prefix.anndist.SB.pdf
    /path/to/output/prefix.cluster.HRun_vs_MyHaplotypeScore.pdf
    /path/to/output/prefix.cluster.HRun_vs_QD.pdf
    /path/to/output/prefix.cluster.HRun_vs_SB.pdf
    /path/to/output/prefix.cluster.MyHaplotypeScore_vs_HRun.pdf
    /path/to/output/prefix.cluster.MyHaplotypeScore_vs_QD.pdf
    /path/to/output/prefix.cluster.MyHaplotypeScore_vs_SB.pdf
    /path/to/output/prefix.cluster.QD_vs_HRun.pdf
    /path/to/output/prefix.cluster.QD_vs_MyHaplotypeScore.pdf
    /path/to/output/prefix.cluster.QD_vs_SB.pdf
    /path/to/output/prefix.cluster.SB_vs_HRun.pdf
    /path/to/output/prefix.cluster.SB_vs_MyHaplotypeScore.pdf
    /path/to/output/prefix.cluster.SB_vs_QD.pdf



git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@3936 348d0f76-0448-11de-a6fe-93d51630548a
2010-08-04 18:35:14 +00:00
R An R module that takes in a Variant Recalibration cluster file (file with '@!CLUSTER' lines in it), a tabularized VCF, and optionally a set of loci that should be examined more carefully, and emits a tremendous number of plots. For every annotation used in clustering, the distributions and pair-wise comparison (with ellipses denoting the 2-sigma cluster boundaries) are shown. Each cluster is shaded with a color proportional to its mixture coefficient. 2010-08-04 18:35:14 +00:00
archive Archiving 2010-07-27 02:47:18 +00:00
c Reduce file handle usage. 2010-01-05 18:03:01 +00:00
doc moved to wiki 2009-07-22 16:35:23 +00:00
java Removed hard-coded pointers to references 2010-08-04 17:59:37 +00:00
matlab Another matlab script -- this time for making power and coverage plots over a specific gene region. Lots of fun file reading, string manipulation, and exploration of the set() function 2009-11-30 20:02:25 +00:00
packages Updated resources package descriptor with dbsnp 129 for b37. 2010-08-03 02:42:48 +00:00
perl 1. Updated tests and added integration test for liftover code. 2010-07-12 17:58:18 +00:00
python Be smart about the headers. 2010-07-30 16:11:16 +00:00
ruby Adding the ruby directory, and a simple script to restart Bamboo 2009-12-03 22:48:48 +00:00
scala Slightly smarter interval list dealing (whole exome intervals are .interval_list, whole genome are .interval.list). Also use BTI with the Genomic Annotator 2010-07-29 22:04:02 +00:00
settings fix for a bug deep in the tribble indexing: if you had a single record in the first contig, the second contig's index blocks would point to the wrong file seek location, and you'd see no 2010-07-23 18:39:55 +00:00
shell a) Add input argument (-ncrate) to BeagleOutputToVCFWalker. If the genotype posterior error probability is higher than this threshold, we declare No-call at this genotype. 2010-07-06 18:33:28 +00:00
testdata and add changes to the vcf used in testing 2010-06-25 02:56:02 +00:00
LICENSE Adding a license to the root directory in case BOSC checks for one. Has the 2010-04-20 16:04:29 +00:00
build.xml A Java sizeof, implemented using the Java instrumentation API. Can either get the memory consumed either only by a single 2010-07-27 18:44:15 +00:00
ivy.xml adding the annotations for findbugs as dependencies in the GATK. They have to be in the default config so that we can 2010-07-19 16:34:57 +00:00