gatk-3.8/java
jmaguire 6e180ed44e Unified caller is go.
AlleleFrequencyWalker and related classes work equally well for 2 or 200 chromosomes. 

Single Sample Calling:

	Allele Frequency Metrics (LOD >= 5)
	-------------------------------------------------
	Total loci                            : 171575
	Total called with confidence          : 168615 (98.27%)
	Number of variants                    : 111 (0.07%) (1/1519)
	Fraction of variant sites in dbSNP    : 87.39%
	-------------------------------------------------
	
    Hapmap metrics are coming up all zero. Will fix.

Pooled Calling:

	AAF r-squared after EM is 0.99. 
    AAF r-squared after EM for alleles < 20% (in pools of ~100-200 chromosomes) is 0.95 (0.75 before EM)

    Still not using fractional genotype counts in EM. That should improve r-squared for low frequency alleles.


Chores still outstanding:
    - make a real pooled caller walker (as opposed to my experiment framework).
    - add fractional genotype counts to EM cycle.
    - add pool metrics to the metrics class? *shrug* we don't really have truth outside of a contrived experiment...



git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@380 348d0f76-0448-11de-a6fe-93d51630548a
2009-04-13 12:29:51 +00:00
..
src/org/broadinstitute/sting Unified caller is go. 2009-04-13 12:29:51 +00:00
test/org/broadinstitute/sting Added basic performance testing so I can make sure concurrent access doesn't slow down overall fasta access. 2009-04-12 18:05:56 +00:00