gatk-3.8/protected/java
Mark DePristo 64b4d80729 Make BQSR calculateIsIndel robust to indel CIGARs are start/end of read
-- The previous implementation attempted to be robust to this, but not all cases were handled properly.  Added a helper function updateInde() that bounds up the update to be in the range of the indel array, and cleaned up logic of how the method works.  The previous behavior was inconsistent across read fwd/rev stand, so that the indel cigars at the end of read were put at the start of reads if the reads were in the forward strand but not if they were in the reverse strand.  Everything is now consistent, as can be seen in the symmetry of the unit tests:

        tests.add(new Object[]{"1D3M",   false, EventType.BASE_DELETION, new int[]{0,0,0}});
        tests.add(new Object[]{"1M1D2M", false, EventType.BASE_DELETION, new int[]{1,0,0}});
        tests.add(new Object[]{"2M1D1M", false, EventType.BASE_DELETION, new int[]{0,1,0}});
        tests.add(new Object[]{"3M1D",   false, EventType.BASE_DELETION, new int[]{0,0,1}});

        tests.add(new Object[]{"1D3M",   true, EventType.BASE_DELETION, new int[]{1,0,0}});
        tests.add(new Object[]{"1M1D2M", true, EventType.BASE_DELETION, new int[]{0,1,0}});
        tests.add(new Object[]{"2M1D1M", true, EventType.BASE_DELETION, new int[]{0,0,1}});
        tests.add(new Object[]{"3M1D",   true, EventType.BASE_DELETION, new int[]{0,0,0}});

        tests.add(new Object[]{"4M1I",   false, EventType.BASE_INSERTION, new int[]{0,0,0,1,0}});
        tests.add(new Object[]{"3M1I1M", false, EventType.BASE_INSERTION, new int[]{0,0,1,0,0}});
        tests.add(new Object[]{"2M1I2M", false, EventType.BASE_INSERTION, new int[]{0,1,0,0,0}});
        tests.add(new Object[]{"1M1I3M", false, EventType.BASE_INSERTION, new int[]{1,0,0,0,0}});
        tests.add(new Object[]{"1I4M",   false, EventType.BASE_INSERTION, new int[]{0,0,0,0,0}});

        tests.add(new Object[]{"4M1I",   true, EventType.BASE_INSERTION, new int[]{0,0,0,0,0}});
        tests.add(new Object[]{"3M1I1M", true, EventType.BASE_INSERTION, new int[]{0,0,0,0,1}});
        tests.add(new Object[]{"2M1I2M", true, EventType.BASE_INSERTION, new int[]{0,0,0,1,0}});
        tests.add(new Object[]{"1M1I3M", true, EventType.BASE_INSERTION, new int[]{0,0,1,0,0}});
        tests.add(new Object[]{"1I4M",   true, EventType.BASE_INSERTION, new int[]{0,1,0,0,0}});

-- delivers #50445353
2013-05-31 13:58:37 -04:00
..
src/org/broadinstitute/sting Make BQSR calculateIsIndel robust to indel CIGARs are start/end of read 2013-05-31 13:58:37 -04:00
test/org/broadinstitute/sting Make BQSR calculateIsIndel robust to indel CIGARs are start/end of read 2013-05-31 13:58:37 -04:00