Mark DePristo 5632c13bf2 Resolves GSA-681 / Compressed VCF.gz output is too big because of unnecessary call to flush(). ... -- Now compressed output VCFs are properly blocked compressed (i.e., they are actually smaller than the uncompressed VCF)		2012-12-12 10:27:07 -05:00
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gatk	Resolves GSA-681 / Compressed VCF.gz output is too big because of unnecessary call to flush().	2012-12-12 10:27:07 -05:00
utils/pairhmm	Refactoring the PairHMM util class to allow for multiple implementations which can be specified by the callers via an enum argument. Adding an optimized PairHMM implementation which caches per-read calculations as well as a logless implementation which drastically reduces the runtime of the HMM while also increasing the precision of the result. In the HaplotypeCaller we now lexicographically sort the haplotypes to take maximal benefit of the haplotype offset optimization which only recalculates the HMM matrices after the first differing base in the haplotype. Many thanks to Mauricio for all the initial groundwork for these optimizations. The change to the one HC integration test is in the fourth decimal of HaplotypeScore.	2012-10-20 16:38:18 -04:00