gatk-3.8/scala/qscript/rpoplin/variantRecalibrator.scala

57 lines
1.9 KiB
Scala
Executable File

import org.broadinstitute.sting.queue.extensions.gatk._
import org.broadinstitute.sting.queue.QScript
class variantRecalibrator extends QScript {
@Argument(doc="gatkJarFile")
var gatkJarFile: File = _
def script = {
val gList = List(30)
val sList = List(0.0001, 0.01)
val dList = List(0.0001, 1000.0)
val bList = List(1.0, 1.3)
for (g: Int <- gList) {
for (s: Double <- sList) {
for (d: Double <- dList) {
for(b: Double <- bList) {
// Using classes defined by QueueGATKExtensions.jar
val gvc = new GenerateVariantClusters
val vr = new VariantRecalibrator
gvc.jarFile = gatkJarFile
gvc.rodBind :+= RodBind("input20", "VCF", new File("/broad/shptmp/rpoplin/CEUTSI.chr20.filtered.vcf"))
gvc.logging_level = "INFO"
gvc.intervalsString :+= "20"
gvc.use_annotation ++= List("QD", "SB", "HaplotypeScore", "HRun")
gvc.path_to_resources = "/humgen/gsa-scr1/rpoplin/sting_dev_vb/R/"
gvc.maxGaussians = Some(g)
gvc.shrinkage = Some(s)
gvc.shrinkageFormat = "%.6f"
gvc.dirichlet = Some(d)
gvc.dirichletFormat = "%.6f"
gvc.clusterFile = "g%d_s%.6f_d%.6f_b%.2f.cluster".format(g,s,d,b)
gvc.jobOutputFile = new File(gvc.clusterFile.stripSuffix(".cluster") + ".gvc.out")
vr.jarFile = gatkJarFile
vr.rodBind :+= RodBind("input20", "VCF", new File("/broad/shptmp/rpoplin/CEUTSI.chr20.filtered.vcf"))
vr.logging_level = "INFO"
vr.intervalsString :+= "20"
vr.target_titv = Some(2.1)
vr.ignore_filter :+= "HARD_TO_VALIDATE"
vr.path_to_resources = "/humgen/gsa-scr1/rpoplin/sting_dev_vb/R/"
vr.clusterFile = gvc.clusterFile
vr.jobOutputFile = new File(vr.clusterFile.stripSuffix(".cluster") + ".vr.out")
vr.backOff = Some(b)
vr.backOffFormat = "%.2f"
add(gvc, vr)
}
}
}
}
}
}