gatk-3.8/protected/java/test/org/broadinstitute/sting/gatk/walkers
Mark DePristo 33720b83eb No longer merge overlapping fragments from HaplotypeCaller
-- Merging overlapping fragments turns out to be a bad idea.  In the case where you can safely merge the reads you only gain a small about of overlapping kmers, so the potential gains are relatively small.  That's in contrast to the very large danger of merging reads inappropriately, such as when the reads only overlap in a repetitive region, and you artificially construct reads that look like the reference but actually may carry a larger true insertion w.r.t. the reference.  Because this problem isn't limited to repetitive sequeuence, but in principle could occur in any sequence, it's just not safe to do this merging.  Best to leave haplotype construction to the assembly graph.
2013-06-13 15:05:32 -04:00
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annotator Refactor rsID and overlap detection in VariantOverlapAnnotator utility class 2013-06-10 15:51:13 -04:00
beagle Updated all JAVA file licenses accordingly 2013-01-10 17:06:41 -05:00
bqsr Make BQSR calculateIsIndel robust to indel CIGARs are start/end of read 2013-05-31 13:58:37 -04:00
compression/reducereads Fix error in merging code in HC 2013-05-31 16:29:29 -04:00
diagnostics Update MD5s and the Diagnose Target scala script 2013-05-13 12:06:17 -04:00
diffengine Fixed issues raised by Appistry QA (mostly small fixes, corrections & clarifications to GATKDocs) 2013-03-12 10:57:14 -04:00
fasta Updated all JAVA file licenses accordingly 2013-01-10 17:06:41 -05:00
filters Don't allow users to specify keys and IDs that contain angle brackets or equals signs (not allowed in VCF spec). 2013-04-05 00:52:32 -04:00
genotyper Refactor rsID and overlap detection in VariantOverlapAnnotator utility class 2013-06-10 15:51:13 -04:00
haplotypecaller No longer merge overlapping fragments from HaplotypeCaller 2013-06-13 15:05:32 -04:00
indels Secondary alignments were not handled correctly in IndelRealigner 2013-05-06 19:09:10 -04:00
phasing Updated all JAVA file licenses accordingly 2013-01-10 17:06:41 -05:00
validation MathUtils.randomSubset() now uses Collections.shuffle() (indirectly, through the other methods 2013-03-29 14:52:10 -04:00
varianteval Move some VCF/VariantContext methods back to the GATK based on feedback 2013-01-29 16:56:55 -05:00
variantrecalibration Update MD5s for VQSR header change 2013-04-16 11:45:45 -04:00
variantutils CombineVariants no longer adds PASS to unfiltered records 2013-05-20 16:53:51 -04:00