-- Adding changes to CombineVariants to work with the Reference Model mode of the HaplotypeCaller. -- Added -combineAnnotations mode to CombineVariants to merge the info field annotations by taking the median -- Added new StrandBiasBySample genotype annotation for use in computing strand bias from single sample input vcfs -- Bug fixes to calcGenotypeLikelihoodsOfRefVsAny, used in isActive() as well as the reference model -- Added active region trimming capabilities to the reference model mode, not perfect yet, turn off with --dontTrimActiveRegions -- We only realign reads in the reference model if there are non-reference haplotypes, a big time savings -- We only realign reads in the reference model if the read is informative for a particular haplotype over another -- GVCF blocks will now track and output the minimum PLs over the block -- MD5 changes! -- HC tests: from bug fixes in calcGenotypeLikelihoodsOfRefVsAny -- GVCF tests: from HC changes above and adding in active region trimming |
||
|---|---|---|
| .. | ||
| annotator | ||
| beagle | ||
| bqsr | ||
| compression/reducereads | ||
| diagnostics | ||
| diffengine | ||
| fasta | ||
| filters | ||
| genotyper | ||
| haplotypecaller | ||
| indels | ||
| phasing | ||
| validation | ||
| varianteval | ||
| variantrecalibration | ||
| variantutils | ||