gatk-3.8/public/c++/VectorPairHMM/baseline.cc

98 lines
2.5 KiB
C++

#include "headers.h"
#include "template.h"
extern uint64_t exceptions_array[128];
template<class NUMBER>
NUMBER compute_full_prob(testcase *tc, NUMBER *before_last_log = NULL)
{
int r, c;
int ROWS = tc->rslen + 1;
int COLS = tc->haplen + 1;
Context<NUMBER> ctx;
NUMBER M[ROWS][COLS];
NUMBER X[ROWS][COLS];
NUMBER Y[ROWS][COLS];
NUMBER p[ROWS][6];
p[0][MM] = ctx._(0.0);
p[0][GapM] = ctx._(0.0);
p[0][MX] = ctx._(0.0);
p[0][XX] = ctx._(0.0);
p[0][MY] = ctx._(0.0);
p[0][YY] = ctx._(0.0);
for (r = 1; r < ROWS; r++)
{
int _i = tc->i[r-1] & 127;
int _d = tc->d[r-1] & 127;
int _c = tc->c[r-1] & 127;
p[r][MM] = ctx._(1.0) - ctx.ph2pr[(_i + _d) & 127];
p[r][GapM] = ctx._(1.0) - ctx.ph2pr[_c];
p[r][MX] = ctx.ph2pr[_i];
p[r][XX] = ctx.ph2pr[_c];
p[r][MY] = ctx.ph2pr[_d];
p[r][YY] = ctx.ph2pr[_c];
//p[r][MY] = (r == ROWS - 1) ? ctx._(1.0) : ctx.ph2pr[_d];
//p[r][YY] = (r == ROWS - 1) ? ctx._(1.0) : ctx.ph2pr[_c];
}
for (c = 0; c < COLS; c++)
{
M[0][c] = ctx._(0.0);
X[0][c] = ctx._(0.0);
Y[0][c] = ctx.INITIAL_CONSTANT / (tc->haplen);
}
for (r = 1; r < ROWS; r++)
{
M[r][0] = ctx._(0.0);
X[r][0] = X[r-1][0] * p[r][XX];
Y[r][0] = ctx._(0.0);
}
NUMBER result = ctx._(0.0);
for (r = 1; r < ROWS; r++)
for (c = 1; c < COLS; c++)
{
fexcept_t flagp;
char _rs = tc->rs[r-1];
char _hap = tc->hap[c-1];
int _q = tc->q[r-1] & 127;
NUMBER distm = ctx.ph2pr[_q];
if (_rs == _hap || _rs == 'N' || _hap == 'N')
distm = ctx._(1.0) - distm;
else
distm = distm/3;
//feclearexcept(FE_ALL_EXCEPT);
M[r][c] = distm * (M[r-1][c-1] * p[r][MM] + X[r-1][c-1] * p[r][GapM] + Y[r-1][c-1] * p[r][GapM]);
//M[r][c] = (M[r-1][c-1] * p[r][MM] + X[r-1][c-1] * p[r][GapM] + Y[r-1][c-1] * p[r][GapM]);
//STORE_FP_EXCEPTIONS(flagp, exceptions_array);
//feclearexcept(FE_ALL_EXCEPT);
X[r][c] = M[r-1][c] * p[r][MX] + X[r-1][c] * p[r][XX];
//STORE_FP_EXCEPTIONS(flagp, exceptions_array);
//feclearexcept(FE_ALL_EXCEPT);
Y[r][c] = M[r][c-1] * p[r][MY] + Y[r][c-1] * p[r][YY];
//STORE_FP_EXCEPTIONS(flagp, exceptions_array);
}
for (c = 0; c < COLS; c++)
{
result += M[ROWS-1][c] + X[ROWS-1][c];
}
if (before_last_log != NULL)
*before_last_log = result;
return result;
//return ctx.LOG10(result) - ctx.LOG10_INITIAL_CONSTANT;
}
template double compute_full_prob<double>(testcase* tc, double* nextbuf);
template float compute_full_prob<float>(testcase* tc, float* nextbuf);