/* * Copyright (c) 2010 The Broad Institute * * Permission is hereby granted, free of charge, to any person * obtaining a copy of this software and associated documentation * files (the "Software"), to deal in the Software without * restriction, including without limitation the rights to use, * copy, modify, merge, publish, distribute, sublicense, and/or sell * copies of the Software, and to permit persons to whom the * Software is furnished to do so, subject to the following * conditions: * * The above copyright notice and this permission notice shall be * included in all copies or substantial portions of the Software. * * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR * THE USE OR OTHER DEALINGS IN THE SOFTWARE. */ package org.broadinstitute.sting.playground.tools.vcf; import org.broad.tribble.vcf.VCFHeader; import org.broad.tribble.vcf.VCFRecord; import org.broadinstitute.sting.commandline.CommandLineProgram; import org.broadinstitute.sting.commandline.Argument; import org.broadinstitute.sting.utils.genotype.vcf.*; import java.io.*; import net.sf.picard.util.Interval; //import org.apache.commons.math.optimization.*; //import org.apache.commons.math.optimization.direct.*; //import org.apache.commons.math.analysis.MultivariateRealFunction; // Program for frequency-specific VCF-files. /** * @author jmaguire */ class VCFMerge extends CommandLineProgram { @Argument(fullName = "vcf1", shortName = "vcf1", doc = "file to open", required = true) public String filename1; @Argument(fullName = "vcf2", shortName = "vcf2", doc = "file to open", required = true) public String filename2; @Argument(fullName = "out", shortName = "out", doc = "file to write results to", required = true) public String output_filename; @Argument(fullName = "auto_correct", shortName = "auto_correct", doc = "auto-correct the VCF file if it's off-spec", required = false) public Boolean autocorrect = false; @Argument(fullName = "verbose", shortName = "verbose", doc = "print way too much debugging output", required = false) public Boolean verbose = false; @Override protected int execute() { VCFReader reader1; VCFReader reader2; if (autocorrect) { reader1 = new VCFReader(new File(filename1),new VCFHomogenizer()); reader2 = new VCFReader(new File(filename2),new VCFHomogenizer()); } else { reader1 = new VCFReader(new File(filename1)); reader2 = new VCFReader(new File(filename2)); } VCFHeader header1 = reader1.getHeader(); VCFHeader header2 = reader2.getHeader(); VCFRecord record1 = reader1.next(); VCFRecord record2 = reader2.next(); VCFWriter writer = new VCFWriter(new File(output_filename)); writer.writeHeader(header1); while(true) { if ((record1 == null) && (record2 == null)) { break; } else if (record1 == null) { writer.addRecord(record2); record2 = reader2.next(); continue; } else if (record2 == null) { writer.addRecord(record1); record1 = reader1.next(); continue; } if (verbose) { System.out.printf("RECORD1: %s\n", record1.toStringEncoding(header1)); System.out.printf("RECORD2: %s\n", record2.toStringEncoding(header2)); } if (record1.isFiltered()) { record1 = reader1.next(); continue; } if (record2.isFiltered()) { record2 = reader2.next(); continue; } Interval interval1 = VCFTool.getIntervalFromRecord(record1); Interval interval2 = VCFTool.getIntervalFromRecord(record2); int comparison = VCFTool.compareIntervals(interval1, interval2); if (comparison == 0) { // records match! Emit one. writer.addRecord(record1); record1 = reader1.next(); record2 = reader2.next(); } else if (comparison > 0) { writer.addRecord(record2); record2 = reader2.next(); } else if (comparison < 0) { writer.addRecord(record1); record1 = reader1.next(); } } writer.close(); return 0; } }