-- Previous IO stub was hardcoded to write VCF. So when you ran -nt 2 -o my.bcf you actually created intermediate VCF files that were then encoded single threaded as BCF. Now we emit natively per thread BCF, and use the fast mergeInfo code to read BCF -> write BCF. Upcoming optimizations to avoid decoding genotype data unnecessarily will enable us to really quickly process BCF2 in parallel
-- VariantContextWriterStub forces BCF output for intermediate files
-- Nicer debug log message in BCF2Codec
-- Turn off debug logging of BCF2LazyGenotypesDecoder
-- BCF2FieldWriterManager now uses .debug not .info, so you won't see all of that field manager debugging info with BCF2 any longer
-- VariantContextWriterFactory.isBCFOutput now has version that accepts just a file path, not path + options
-- Expanded unit tests
-- Support for clean logging of results to logger
-- Refactored MyTime into AutoFormattingTime in Utils, out of TraversalEngine, for cleanliness and reuse
-- Added docs and contracts to StateMonitoringThreadFactory
-- Cut out CountCovariates and TableRecalibrator (no longer in GATK2)
-- Parallelism tests go up to 32 cores by default now
-- Only tests 1.6 and 2.0 now
-- Useful -justUG option to just run all of the UG performance tests
-- GenomeLocParser cache was a major performance bottleneck in parallel GATK performance. With 10 thread > 50% of each thread's time was spent blocking on the MasterSequencingDictionary object. Made this a thread local variable.
-- Now we can run the GATK with 48 threads efficiently on GSA4!
-- Running -nt 1 => 75 minutes (didn't let is run all of the way through so likely would take longer)
-- Running -nt 24 => 3.81 minutes
Use "path" instead of "pathconvert" to construct the external.gatk.classpath.
This allows the path to evolve as the build progresses, instead of being
fixed early on to a value that (in some cases) could be incorrect.
Implemented a mixin called "RetryMemoryLimit" which will by default double the memory.
GridEngine memory request parameter can be selected on the command line via '-resMemReqParam mem_free' or '-resMemReqParam virtual_free'.
Java optimizations now enabled by default:
- Only 4 GC threads instead of each job using java's default O(number of cores) GC threads. Previously on a machine with N cores if you have N jobs running and java allocates N GC threads by default, then the machines are using up to N^2 threads if all jobs are in heavy GC (thanks elauzier).
- Exit if GC spends more than 50% of time in GC (thanks ktibbett).
- Exit if GC reclaims lest than 10% of max heap (thanks ktibbett).
Added a -noGCOpt command line option to disable new java optimizations.
-- The previously expanded ones are actually the missing values in the range. The previous ranges were correct. Removed the TODO to confirm them, as they are now officially confirmed
-- Includes header page
-- Table of arguments (Arguments)
-- Summary of counts (RecalData0)
-- Summary of counts by qual (RecalData1)
-- Fixed bug in output that resulted in covariates list always being null (updated md5s accordingly)
-- BQSR.R loads all relevant libaries now, include gplots, grid, and gsalib to run correctly
-- Added Write method to BCF2 types that directly converts int value to byte stream. Deleted writeRawBytes(int)
-- encodeTypeDescriptor semi-inlined into encodeType so that the tests for overflow are done in just one place
-- Faster implementation of determineIntegerType for int[] values
-- BCF2Type enum has an overloaded method to read the type as an int from an input stream. This gets rid of a case statement and replaces it with just minimum tiny methods that should be better optimized. As side effect of this optimization is an overall cleaner code organization
-- All low-level reads throw IOException instead of catching it directly. This allows us to not try/catch in readByte, improving performance by 5% or so
-- Optimize encodeTypeDescriptor with final variables. Avoid using Math.min instead do inline comparison
-- Inlined willOverflow directly in its single use
Mark DePristo
Mauricio Carneiro
David Roazen
Guillermo del Angel
Eric Banks
Khalid Shakir
Ami Levy Moonshine
Joel Thibault
Ryan Poplin