Commit Graph

5 Commits (748787c50971ac091552dc466e5735bd92747a93)

Author SHA1 Message Date
chartl 1b310401fe Due to the approximation not being well-founded in this case, (and the non-existence of a pre-computed table at this time), pushing up the cutoff
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@5405 348d0f76-0448-11de-a6fe-93d51630548a
2011-03-08 16:24:42 +00:00
chartl 77fe902dbd Testing modules now use wider windows and heftier shift, hopefully this will remove some of the noisiness of the results. Some UStatistics were changed to TStatistics to try and limit noisiness as well. Walker will also additionally write out wiggle files directly (which can be converted into "proper" tdf files via igvtools tile [args] [in].wig [out].tdf [ref]) subject to some restrictions. MWU could get stuck in a long-running recursive regime, it'd be nice to have a table lookup or a good small-n large-m approximation, for now the uniform should work just fine.
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@5403 348d0f76-0448-11de-a6fe-93d51630548a
2011-03-08 15:26:13 +00:00
chartl 60ddc08cdf Added a boatload of new case-control association modules. Switched the U-test to use longs rather than ints (it just so happened that I overflowed and started getting negative U statistics. Not good.) Added the ALL association type for ease of specifying that we want to throw the book at something. Added an svn-commit.tmp~ because i can't get rid of it even with --force. Hopefully I can remove it after.
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@5386 348d0f76-0448-11de-a6fe-93d51630548a
2011-03-06 21:58:12 +00:00
chartl a40a8006b5 Added in unit tests for the statistics calculated by the test runner; and bug-fixes to the calculations; so we have some assurance that the statistics coming out the back-end are correct.
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@5380 348d0f76-0448-11de-a6fe-93d51630548a
2011-03-06 16:54:02 +00:00
chartl 9ca1dd5d62 Miscellaneous changes:
- RefMetaDataTracker: grabbing variant contexts given a prefix (not sure where else this was implemented, if someone can show me I'll remove it)
 - VCFUtils: grabbing VCF headers given a prefix 
 - MathUtils: Useful functions for calculating statistics on collections of Numbers
 - VariantAnnotator: Made isUniqueHeaderLine a public static method -- maybe this should go into a different class. Not sure.
 - Associations: PluginManager now used to propagate classes, implementations for Z,T,U tests, slight alteration to format to make the objects stored
      in the window optionally different from those returned by whatever statistic is run across the window
Added:
 - MannWhitneyU. Started to fix up WilcoxonRankSum but there are comments in there questioning the validity of some of the code, and I'm sure that
    it's actually doing a U test. This implementation includes the direct calculation of p-values for small sample sizes, and a uniform approximation
    for when one of the sample sets is small, and the other large. Unit tests to follow.
 - BootstrapCallsMerger: takes n VCFs which have been called on the same samples; merges them together while averaging the annotations
 - BootstrapCalls.q: qscript for testing the effectiveness of boostrap low-pass calling on the exome
 


git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@5372 348d0f76-0448-11de-a6fe-93d51630548a
2011-03-03 22:43:36 +00:00