Commit Graph

282 Commits (668c7da33d00bb0eecb0444b85aeccd9bb03e607)

Author SHA1 Message Date
hanna dd228880ed Partially implemented NewHotnessGenotypeLikelihoodsTest caused the tests to fail.
Ouch!  So hot it burned me.


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2009-08-10 20:45:44 +00:00
depristo a864c2f025 Updated polarized reference priors, need DiploidGenotypePriors class that is directly used by the NewHotness genotypelikelihoods, more bug fixes and refactoring, etc.
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2009-08-07 19:00:06 +00:00
depristo bbd7bec5db Continuing cleanup of SSG. GenotypeLikelihoods now have extensive testing routines. DiploidGenotype supports het, homref, etc calculations. SSG has been cleaned up to remove old garbage functionality. Also now supports output to standard output by simply omitting varout
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2009-08-05 22:25:30 +00:00
hanna 48713e154c Windowed access to the reference.
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2009-08-05 16:29:15 +00:00
hanna 21d1eba502 Cleaned division of responsibilities between arguments to map function. Reference has been changed
from an array of bases to an object (ReferenceContext), and LocusContext has been renamed to reflect
the fact that it contains contextual information only about the alignments, not the locus in general.


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2009-08-04 21:01:37 +00:00
aaron bca894ebce Adding the intial changes for the new Genotyping interface. The bullet points are:
- SSG is much simpler now
- GeliText has been added as a GenotypeWriter
- AlleleFrequencyWalker will be deleted when I untangle the AlleleMetric's dependance on it
- GenotypeLikelihoods now implements GenotypeGenerator, but could still use cleanup

There is still a lot more work to do, but this is a good initial check-in.

git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@1335 348d0f76-0448-11de-a6fe-93d51630548a
2009-07-29 19:43:59 +00:00
hanna 7a13647c35 Support for specifying SAMFileReaders and SAMFileWriters as @Arguments directly. *Very*
rough initial implementation, but should provide enough support so that people can stop
creating SAMFileWriters in reduceInit.


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2009-07-29 16:11:45 +00:00
hanna 2db86b7829 Move the cleaned read injector test from playground to core. Remove CovariateCounterTest's dependency on the CleanedReadInjector. Start doing a bit of cleanup on the CLP's FieldParsers.
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2009-07-24 19:44:04 +00:00
aaron 0b16253db3 an iterator to fix the problem where read-based interval traversals are getting duplicate reads because reads span the two intervals.
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2009-07-23 23:59:48 +00:00
aaron b4adb5133a GLF rod as a AllelicVariant object.
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2009-07-21 00:55:52 +00:00
aaron 9ecb3e0015 adding GLFRods with tests and some other code changes
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2009-07-15 15:30:19 +00:00
aaron d86717db93 Refactoring of the traversal engine base class, I removed a lot of old code.
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2009-07-09 21:57:00 +00:00
hanna da4d26b1ea Enum support for command-line argument system, and some cleanup for hacks to the CleanedReadInjector that were required because Enum support was missing.
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2009-07-08 20:26:16 +00:00
hanna 433ad1f060 Cleanup...deprecate FastaSequenceFile2 in favor of IndexedFastaSequenceFile or ReferenceSequenceFile from Picard, depending on the application.
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2009-07-08 18:49:08 +00:00
hanna d8fbb2b62c Refactoring; make a better home for the MalformedReadFilteringIterator.
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2009-07-08 16:54:20 +00:00
aaron f6a273a537 other fixes for some broken unit tests
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2009-07-07 05:53:13 +00:00
aaron 033bafe7a1 fixed sam by reads test for the new filtering code
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2009-07-07 05:45:50 +00:00
depristo b9d533042e Two-tailed HardyWeinberg test implemented. VariantEval now separate violations from summary outputs for clarity; Fixing problems with CovariateCounterTest and TabularRodTest
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2009-07-06 22:02:04 +00:00
aaron bc17ff567a When you get the reference string for a read that is mapped partially off the end of a contig, the string is masked with X's for base positions without corresponding reference positions. Now with a test case!
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@1156 348d0f76-0448-11de-a6fe-93d51630548a
2009-07-02 14:15:50 +00:00
hanna 9b182e3063 Prep for documenting command-line arguments: delete some arguments that don't make sense any more given
the state of the traversals and GATK input requirements: all_loci (replaced by walker annotation), max
OTF sorts (bam files must be sorted and indexed), threaded io (replaced by data sharding framework).


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2009-07-01 18:23:35 +00:00
aaron 03f8177a53 When you get the reference string for a read that is mapped partially off the end of a contig, the string is masked with X's for base positions without corresponding reference positions.
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2009-06-29 20:51:55 +00:00
aaron 1dcababad1 a fix to make the test run
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2009-06-29 20:24:32 +00:00
depristo 5289230eb8 Version 0.2.1 (released) of the TableRecalibrator
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2009-06-25 22:50:55 +00:00
hanna ad3a3aa350 First pass at passing lists of files / lists of interval arguments work. Note that the interval
ROD system will throw up its hands and not deal with intervals at all if multiple interval files 
are passed in (see JIRA GSA-95). 


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2009-06-25 20:44:23 +00:00
aaron 0a16519aa2 a couple of additions to the tests, plus a change to the artificial resource pool to support the queryContained flag
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2009-06-25 18:30:32 +00:00
aaron 5b1c23a7f2 changes to fix and test the interval based traversals
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2009-06-25 17:54:15 +00:00
hanna ef546868bf Pooling of unmapped reads -- improves runtime of files with tons of unmapped reads by an order of magnitude.
Desperately needs cleanup.


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2009-06-23 23:48:06 +00:00
aaron bcb64d92e9 Aaron: 1, GenomeLoc: 0. I changed our GenomeLoc class, seperating the creation of a genome loc (with the reference setup) to a parser class. GenomeLoc now just represents the actual genomic postion. The constructors are now package-protected (to enforce using the parser), but we may want to expose some constructors in the future.
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2009-06-22 14:39:41 +00:00
depristo 8ac40e8e2d Updated version of the recalibration tool
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2009-06-19 17:45:47 +00:00
aaron 6ee64c7e43 added changes to support alec toUnmappedRead seek. Huge improvements (orders of magnitude) in unmapped read performance.
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2009-06-16 22:15:56 +00:00
ebanks 647b8a1ab0 Fix TabularROD printing and testing so Aaron stops nagging me.
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2009-06-16 15:49:26 +00:00
hanna 71e3825fa1 First pass of a walker for Eric that searches through an input BAM file for unclean reads, injecting the cleaned reads in their place and outputting the composite result.
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2009-06-11 20:18:13 +00:00
aaron 63b5c12cbd Changed dataSources to datasources, to be consistant with the rest of our package names. Also, this makes me champion in the largest check-in contest.
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2009-06-11 18:13:22 +00:00
aaron 195b4ea7b4 a rename for consistancy of Sam to SAM, creating a genotype utils dir, and moving the GLF code into it.
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2009-06-11 17:46:06 +00:00
aaron ec2f015447 fixed a bunch of comments and license headers.
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2009-06-10 14:10:46 +00:00
hanna dc6a9ca196 Pooling resources to lower memory consumption.
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2009-06-10 13:39:32 +00:00
aaron 36c98b9d6c added tools to test read based traversals using the artificial in-memory SAM file tools, and testing of the PrintReadsWalker
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2009-06-10 01:52:25 +00:00
aaron a8a2d0eab9 added support for the -M option in traversals.
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2009-06-08 15:12:24 +00:00
depristo 819862e04e major restructuring of generalized variant analysis framework. Now trivally easy to add additional analyses. Easy partitioning of all analyses by features, such as singleton status. Now has transition/transversional bias, counting, dbSNP coverage, HWE violation, selecting of variants by presence/absense in dbs. Also restructured the ROD system to make it easier to add tracks. Also, added the interval track -- if you provide an interval list, then the system autoatmically makese this available to you as a bound rod -- you can always find out where you are in the interval at every site. Python scripts improved to handle more merging, etc, into population snps.
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2009-06-05 23:34:37 +00:00
aaron 109bef6c08 We're no longer in the read-dropping business.
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2009-06-04 22:37:51 +00:00
hanna 5e8c08ee63 Update to latest version of picard. Change imports in all classes dependent on picard public from import edu.mit.broad.picard... to import net.sf.picard...
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2009-05-28 20:13:01 +00:00
hanna a11bf0f43e Basic unit tests for ReferenceOrderedView, ShardDataProvider. Addressing GSA-25.
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2009-05-27 21:15:01 +00:00
aaron 3c3cd5bb64 Moving some of the data sharding around. A new shard catagory now exits, INTERVAL. This saved a lot of code that was mirroring the same approach in both the read and locus shard strategies.
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2009-05-27 18:24:31 +00:00
hanna 8edba13ded Unit tests for the reference views. Partially addresses GSA-25.
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2009-05-27 17:49:45 +00:00
aaron d994544c47 Added back end code support for Sharding based on genomic location for reads. Changed the sharding
code to take GenomeLocSortedSet instead of a list<GenomeLoc>, and added a bunch of much simplier 
and cleaner test cases.



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2009-05-26 20:57:46 +00:00
hanna 2a5be1debe Cleanup in datasources.providers namespace. Make it easier for others writing traversal engines to use.
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2009-05-22 19:12:00 +00:00
hanna d61a5261c1 Better integration of reference-ordered data into the data sharding system.
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2009-05-21 20:09:32 +00:00
hanna 2c4de7b5c5 Switch TraverseByLoci over to new sharding system, and cleanup some code in passing read files along
the pathway from command line to traversal engine.


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2009-05-15 21:02:12 +00:00
depristo 7834b969b4 Better interface to the tabular ROD, now makes writing files easier. Also has corresponding test files
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2009-05-14 23:20:11 +00:00
aaron 50f32b7f61 Added a shard strategy for the reduce-by-interval traversals. Also fixed bugs that I found along the way.
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2009-05-14 21:20:18 +00:00
depristo 8e9e2f4502 Revised ROD system. Split the system in Basic type and interface. Enabled more control over rod accessing, including an initialize() function to fetch headers and other options from the file. Added general tabular rod, which has a named columns and supports a map<String,String> interface. Comes with shiny new Junit system for RODs. Also, added simple python script for accessing picard data.
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2009-05-14 21:06:28 +00:00
aaron 7aa90757ac Moved the iterators over to the StingSAMIterator interface. This will help us ensure that iterators that need to be closed get closed.
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2009-05-14 16:52:18 +00:00
aaron 0215905bb6 Added an adapter class, that will adapt plain iterators and closeable iterators of SAMRecords into STingSAMIterators. Also unit tests.
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2009-05-14 15:17:32 +00:00
hanna d14cab0be7 Added IterableLocusContextQueue and test. Cleaned up tests, adding BaseTest where it didn't exist. Enhanced test runner to run only classes ending in ...Test.java, so that utility classes can sit alongside the tests but won't be run by JUnit.
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2009-05-13 21:32:05 +00:00
hanna 12ae3a22b6 Break locus context data access providers into modular components in preparation for traverse by loci.
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2009-05-13 18:51:16 +00:00
hanna 862b8a6787 intervals_file + genome_loc => intervals.
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2009-05-12 01:04:18 +00:00
aaron ff1b92acc4 Switch over to the GenomeAnalysisEngine/CommandLineGATK system from the GenomeAnalysisTK code.
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2009-05-11 22:05:58 +00:00
aaron 898f65547e Added code to split GenomeAnalysisTK.java into an object concerned with loading command line args, and one that runs the engines. This will allow us to run the GATK from other tools (like Matlab). Also some cleanup to seperate out the legacy traversals and the new style traversals. This is not live yet, and any modifications you need should be made to GenomeAnalysisTK.java for now.
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2009-05-11 02:07:20 +00:00
hanna 6e394490cb Cleanup in preparation for ByLoci traversal. Also did some work minimizing unit tests.
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2009-05-08 21:27:54 +00:00
aaron 0aba688e6f Added a interface that all our SAMRecord iterators should try to code to. This is in the effort to keep our code generic
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2009-05-06 21:40:41 +00:00
aaron 70afda12c4 Cut the test time down
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2009-05-05 22:05:51 +00:00
aaron f5880109a7 Added TraverseReads test, some bug fixes discovered in the traversal test
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2009-05-05 20:36:00 +00:00
aaron 09b0b6b57d Fixes to try and speed up unmapped read traversals. Still not nearly as fast as they should be, but the next step would be to modify samtools code.
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2009-05-05 18:17:07 +00:00
hanna 9f5f6f9bc7 N-way parallelism. Works for small test cases. Untested for large test cases.
-Needs more comprehensive unit testing.
-Needs some basic refactoring.
-Needs rethink of interface boundaries.
-Needs to play more nicely in the /tmp sandbox.


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2009-05-01 19:34:09 +00:00
aaron 63403d32cd Changes to the interface to the simple data source rippled out to a bunch of files.
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2009-04-30 20:35:56 +00:00
hanna 19e4e97f21 Add tag to ignore node class.
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2009-04-30 20:27:34 +00:00
hanna 7f173af2ea Encapsulate output tracking a bit.
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2009-04-30 15:12:13 +00:00
hanna 95d10ba314 Sketch of hierarchical reduce process, with unit tests for some core classes. Requires breakout of inner classes, testing.
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2009-04-29 20:26:16 +00:00
aaron 6b02248298 moved the test cases out of the GenomeAnalysisTK code and into a JUnit test case
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2009-04-28 21:49:17 +00:00
aaron 0720d248ce Adding the test case for by reads sharding of BAM data sources
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2009-04-23 18:01:22 +00:00
aaron 180ff13290 Added a bunch of changes to support the new MicroManager code
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@431 348d0f76-0448-11de-a6fe-93d51630548a
2009-04-15 18:29:38 +00:00
aaron 6db9127f90 Added changes to shattering, refactored SAMBAM into SAM
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@426 348d0f76-0448-11de-a6fe-93d51630548a
2009-04-15 13:52:56 +00:00
aaron e6fb122d7d Added some fixes and new iterator tests
--This lin e, and those below, will be ignored--

A    gatk/iterators
AM   gatk/iterators/BoundedReadIteratorTest.java
M    gatk/dataSources/simpleDataSources/SAMBAMDataSourceTest.java


git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@420 348d0f76-0448-11de-a6fe-93d51630548a
2009-04-14 22:19:36 +00:00
aaron 96248cdec4 Added some output to all the classes, including build in runtime analysis
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@411 348d0f76-0448-11de-a6fe-93d51630548a
2009-04-14 19:14:53 +00:00
hanna 0629f79049 Moved fasta support files into their own package.
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@408 348d0f76-0448-11de-a6fe-93d51630548a
2009-04-14 18:13:23 +00:00
aaron 88ebf1a05b Fied some documentation
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@406 348d0f76-0448-11de-a6fe-93d51630548a
2009-04-14 17:41:38 +00:00
aaron 4b3578e1de Added the base test case, fixed the rest of the test cases to follow suit. Added more verbose output to ant for junit tests.
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@403 348d0f76-0448-11de-a6fe-93d51630548a
2009-04-14 17:11:38 +00:00
aaron eb4b4a053b A bunch of updates to the SAM/BAM data source, along with test cases for the merging of multiple files (it works!).
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@399 348d0f76-0448-11de-a6fe-93d51630548a
2009-04-14 14:19:20 +00:00
aaron 887adcfc7f Some minor fixes to the last check-in
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@387 348d0f76-0448-11de-a6fe-93d51630548a
2009-04-13 18:24:51 +00:00
aaron 9afa101465 Add interval support to the
.__            __    __                
  _____|  |__ _____ _/  |__/  |_  ___________ 
 /  ___/  |  \\__  \\   __\   __\/ __ \_  __ \
 \___ \|   Y  \/ __ \|  |  |  | \  ___/|  | \/
/____  >___|  (____  /__|  |__|  \___  >__|   
     \/     \/     \/                \/       

classes!



git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@352 348d0f76-0448-11de-a6fe-93d51630548a
2009-04-09 21:23:43 +00:00
aaron 8e2f5471a1 Some cleanup to the data source, and another JUnit test case.
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@344 348d0f76-0448-11de-a6fe-93d51630548a
2009-04-09 14:58:05 +00:00
aaron d517245beb Fixes for shattering, added JUnit test case
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@332 348d0f76-0448-11de-a6fe-93d51630548a
2009-04-08 16:37:34 +00:00