27e56b2bb9
Merge pull request #1441 from broadinstitute/rhl_printreads_bqsr_fail
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Throw an exception if the BQSR input covariants file is not found
2016-08-11 16:16:08 -04:00
f6c18a5182
Throw an exception if the BQSR input covariants file is not found
2016-08-11 12:46:14 -04:00
7959324f08
Merge pull request #1451 from broadinstitute/sl_issue_1345_fix_2
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Changed maximum allowed GQB value to 100.
2016-08-05 15:12:20 -04:00
49507faaa3
Changed maximum allowed GQB value to 100.
2016-08-05 13:06:31 -04:00
0630c7befd
Merge pull request #1423 from broadinstitute/rhl_read_sra
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Added support for directly reading SRA runs
2016-08-02 18:10:33 -04:00
a465c87ff8
Added support for directly reading SRA runs
2016-08-02 15:21:14 -04:00
6bca5a060f
Merge pull request #1446 from broadinstitute/sl_issue_1345_fix
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Fixed MD5 broken by PR #1440 .
2016-07-27 21:53:00 -04:00
832a383acd
Fixed MD5 broken by PR #1440 .
2016-07-27 13:51:20 -04:00
9a6ce7a347
Merge pull request #1440 from broadinstitute/sl_issue_1345
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Added exception for GQB values greater than MAX_GENOTYPE_QUAL and tests.
2016-07-26 14:55:59 -04:00
e194b52ef3
Merge pull request #1442 from broadinstitute/vrr_genotype_gvcf_performance_fix
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GenotypeGVCFs performance and QUAL miscalculation fix applied to master.
2016-07-26 13:13:52 -04:00
fef63ce6a8
Make sure that multi-alleleic uninformative PLs (0,0,...,0) stay uninformative after biallelization.
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Addresses issue #1439 (thus #1437 ).
Fixes a bug where non informative PLs were not handled appropriatelly when calculating multi-allelic site QUAL values.
This was resulting in long execution times for very large datasets (~200,000 samples in the case of ExAC2).
2016-07-25 17:19:03 -04:00
3daed9e5a1
Added exception for GQB values greater than MAX_GENOTYPE_QUAL and tests.
2016-07-20 16:48:59 -04:00
b4eb479727
Merge pull request #1417 from broadinstitute/rhl_ggvcf_span_del
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Removed spanning deletions if the deletion was removed
2016-07-19 16:55:06 -04:00
7392c4d1b0
Removed spanning deletions if the deletion was removed
2016-07-19 12:23:49 -04:00
b6908f52f0
Merge pull request #1432 from broadinstitute/rhl_invalid_intervals
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Throw an exception for invalid Picard intervals
2016-07-15 13:02:39 -04:00
4f2e312805
Throw an exception for invalid Picard intervals
2016-07-15 11:20:53 -04:00
c406102e03
Merge pull request #1436 from broadinstitute/ldg_fixBetaTestingAnnotationGroup
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Fixed the BetaTesting annotation group
2016-07-13 16:23:19 -04:00
641382eb8b
Fix BetaTestingAnnotation group
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Add test
2016-07-13 16:05:21 -04:00
5255435f0e
Merge pull request #1433 from broadinstitute/rhl_progress_meter_periodicity
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Enable control of reporting periodicity
2016-07-13 10:14:01 -04:00
aace73e884
Enable control of reporting periodicity
2016-07-13 07:24:03 -04:00
5e39b59ef3
Merge pull request #1429 from broadinstitute/ts_readpos_filter
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Port MuTect1 Clustered Read Position filter to MuTect2
2016-07-12 08:30:51 -04:00
d6d0678b50
Build on Laura's code and finish porting MuTect1 clustered read position filter.
2016-07-11 17:33:08 -04:00
77d8da6bb2
Merge pull request #1431 from broadinstitute/sl_issue_1345
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Fixed merging of GVCF blocks by fixing rounding of GQ values in ReferenceConfidenceModel.
2016-07-06 11:46:39 -07:00
9b32cf5291
Fixed merging of GVCF blocks by fixing rounding of GQ values in ReferenceConfidenceModel.
2016-07-06 10:08:08 -04:00
2c94f74a95
Merge pull request #1404 from broadinstitute/ldg_M2_addM1filters
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MuTect 2: port strand artifact filter from MuTect 1
2016-07-05 13:27:35 -04:00
9c3b928945
Merge pull request #1428 from broadinstitute/vrr_issue_1419_out_of_mem_genotype_gvcfs
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RCM Variant sites merger won't output PL when there are too many alle…
2016-07-01 13:58:38 -04:00
45607d1b30
RCM Variant sites merger won't output PL when there are too many alleles in order to avoid memory issues with large cohort runs.
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Small additional "cosmetic" changes to the code
Addresses issue #1419 .
2016-07-01 11:33:07 -04:00
1ff234e7dd
remove alt alleles, when genotype count is explosively large, based on alleles' highest supporting haplotype score; max tolerable genotype count is controlled by a default value overridable by user
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remove alt alleles, when genotype count is explosively large, based on alleles' highest supporting haplotype score; max tolerable genotype count is controlled by a default value overridable by user
2016-06-30 22:36:49 -04:00
6471bda0cd
Merge pull request #1426 from broadinstitute/ms_excessHetSmallP
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Changes max value output for ExcessHet
2016-06-30 08:26:01 -04:00
63e0865491
Built on Laura's code to port the strand bias filter from M1 and refactored code aroud SomaticGenotypingEngine. Added a new integration test.
2016-06-29 22:46:40 -04:00
4066bcd75c
Add new annotator for M1 clustered read position filter and M1 strand bias filter.
2016-06-29 22:46:37 -04:00
1b921666a7
Change to max value of ExcessHet
2016-06-29 16:33:50 -04:00
db196e709a
Merge pull request #1424 from broadinstitute/ms_rankSumBug
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Fixes Overflow in Rank Sum With Large Pileups
2016-06-29 13:26:28 -04:00
556cc69185
Fix for int overflow in RankSum calculation
2016-06-29 12:02:13 -04:00
b14312a14d
Merge pull request #1389 from broadinstitute/vrr_non_ref_likelihoods_to_median
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Changes to use the median rather than the second best likelihood for …
2016-06-28 16:07:09 -04:00
07052ba8ea
Changes to use the median rather than the second best likelihood for the NON_REF allele
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Addresses issue #1378 following the first proposal using the 'median' rather than the 'mean'.
2016-06-28 13:10:22 -04:00
b80a293848
Merge pull request #1422 from broadinstitute/rhl_htsjdk_picard_2.5.0
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Move htsjdk and picard to version 2.5.0
2016-06-28 12:16:04 -04:00
3c5eac8c17
Move htsjdk and picard to version 2.5.0
2016-06-28 09:42:32 -04:00
23c48bcdb1
Merge pull request #1415 from broadinstitute/shlee-addsupplementarytodocument
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Improve documentation of read filter
2016-06-23 22:11:25 -04:00
6fe80d53d0
Improve documentation
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Clarified that this also filters supplementary alignments.
2016-06-23 16:20:00 -04:00
4eff18a470
Merge pull request #1414 from broadinstitute/rhl_sv_hashmap
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Change HashMap to LinkedHashMap for predictable iteration order.
2016-06-23 12:22:43 -04:00
c6ef81b611
Change HashMap to LinkedHashMap for predictable ordering
2016-06-23 10:48:22 -04:00
679941c1b1
Merge pull request #1412 from broadinstitute/sl_issue_1285
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Allows GatherBqsrReports to accept a .list file as input.
2016-06-22 15:25:19 -04:00
76bb8fd9e5
Allows GatherBqsrReports to accept a .list file as input.
2016-06-22 12:39:18 -04:00
ae8ab33cdd
Merge pull request #1408 from broadinstitute/rhl_sv_non_diploids
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SelectVariants works with non-diploids
2016-06-21 13:52:07 -04:00
427645162b
SelectVariants works with non-diploids
2016-06-21 12:26:13 -04:00
d3862459e9
Merge pull request #1410 from broadinstitute/vrr_bug_1407_no_such_element_exception
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Fixes bug #1407
2016-06-20 15:52:25 -04:00
857459e420
Silly mistake '<' for a '<='. It was causing the exception when the exact number of alleles to drop was matching MAX_DROPPED_ALTERNATIVE_ALLELES_TO_LOG exactly (fixed to 20).
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I change the code to impose a maximum allele list message length instead and in the process I fixed the bug.
2016-06-17 15:22:59 -04:00
6b04f6ae14
Merge pull request #1405 from broadinstitute/sl_issue_1281
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Added regression test for genotyping of spanning deletions in GenotypeGVCFs.
2016-06-15 13:59:14 -04:00
e119feee61
Added regression test for genotyping of spanning deletions in GenotypeGCVFs.
2016-06-15 09:48:26 -04:00
Ron Levine
samuelklee
Samuel Lee
Andrii Nikitiuk
Valentin Ruano Rubio
ldgauthier
Takuto Sato
Steve Huang
meganshand
Geraldine Van der Auwera
sooheelee