Small refactoring: make Haplotype a public class since it will be soon extended and shared with other callers.
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@4100 348d0f76-0448-11de-a6fe-93d51630548a
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@ -34,6 +34,7 @@ import org.broadinstitute.sting.gatk.contexts.variantcontext.*;
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import org.broadinstitute.sting.gatk.refdata.RefMetaDataTracker;
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import org.broadinstitute.sting.gatk.refdata.RefMetaDataTracker;
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import org.broadinstitute.sting.gatk.walkers.annotator.interfaces.*;
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import org.broadinstitute.sting.gatk.walkers.annotator.interfaces.*;
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import org.broadinstitute.sting.utils.*;
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import org.broadinstitute.sting.utils.*;
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import org.broadinstitute.sting.utils.genotype.Haplotype;
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import org.broadinstitute.sting.utils.pileup.*;
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import org.broadinstitute.sting.utils.pileup.*;
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import java.util.*;
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import java.util.*;
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@ -154,7 +155,7 @@ public class HaplotypeScore implements InfoFieldAnnotation, StandardAnnotation {
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// Temp hack to match old implementation's scaling, TBD better behavior
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// Temp hack to match old implementation's scaling, TBD better behavior
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return Arrays.asList(new Haplotype(haplotypeR.bases, 60), new Haplotype(haplotypeA.bases, contextSize));
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return Arrays.asList(new Haplotype(haplotypeR.getBasesAsBytes(), 60), new Haplotype(haplotypeA.getBasesAsBytes(), contextSize));
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}
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}
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else
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else
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return null;
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return null;
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@ -218,14 +219,14 @@ public class HaplotypeScore implements InfoFieldAnnotation, StandardAnnotation {
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}
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}
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else if ((chA == wc)) {
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else if ((chA == wc)) {
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consensusChars[i] = chB;
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consensusChars[i] = chB;
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consensusQuals[i] = haplotypeB.quals[i];
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consensusQuals[i] = haplotypeB.getQuals()[i];
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}
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}
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else if ((chB == wc)){
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else if ((chB == wc)){
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consensusChars[i] = chA;
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consensusChars[i] = chA;
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consensusQuals[i] = haplotypeA.quals[i];
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consensusQuals[i] = haplotypeA.getQuals()[i];
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} else {
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} else {
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consensusChars[i] = chA;
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consensusChars[i] = chA;
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consensusQuals[i] = haplotypeA.quals[i]+haplotypeB.quals[i];
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consensusQuals[i] = haplotypeA.getQuals()[i]+haplotypeB.getQuals()[i];
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}
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}
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@ -289,7 +290,7 @@ public class HaplotypeScore implements InfoFieldAnnotation, StandardAnnotation {
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if ( baseOffset >= read.getReadLength() )
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if ( baseOffset >= read.getReadLength() )
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break;
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break;
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byte haplotypeBase = haplotype.bases[i];
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byte haplotypeBase = haplotype.getBasesAsBytes()[i];
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byte readBase = read.getReadBases()[baseOffset];
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byte readBase = read.getReadBases()[baseOffset];
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boolean matched = BaseUtils.basesAreEqual(readBase, haplotypeBase );
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boolean matched = BaseUtils.basesAreEqual(readBase, haplotypeBase );
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@ -314,41 +315,6 @@ public class HaplotypeScore implements InfoFieldAnnotation, StandardAnnotation {
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FLAT_BASE_PRIORS[i] = Math.log10(1.0 / BaseUtils.Base.values().length);
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FLAT_BASE_PRIORS[i] = Math.log10(1.0 / BaseUtils.Base.values().length);
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}
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}
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private class Haplotype {
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byte[] bases = null;
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double[] quals = null;
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/**
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* Create a simple consensus sequence with provided bases and a uniform quality over all bases of qual
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*
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* @param bases bases
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* @param qual qual
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*/
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Haplotype(byte[] bases, int qual) {
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this.bases = bases;
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quals = new double[bases.length];
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Arrays.fill(quals, (double)qual);
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}
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Haplotype(byte[] bases, double[] quals) {
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this.bases = bases;
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this.quals = quals;
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}
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Haplotype(String bases, double[] quals) {
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this.bases = bases.getBytes();
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this.quals = quals;
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}
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public String toString() { return new String(this.bases); }
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double getQualitySum() {
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double s = 0;
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for (int k=0; k < bases.length; k++) {
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s += quals[k];
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}
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return s;
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}
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}
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public List<String> getKeyNames() { return Arrays.asList("HaplotypeScore"); }
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public List<String> getKeyNames() { return Arrays.asList("HaplotypeScore"); }
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public List<VCFInfoHeaderLine> getDescriptions() { return Arrays.asList(new VCFInfoHeaderLine("HaplotypeScore", 1, VCFHeaderLineType.Float, "Consistency of the site with two (and only two) segregating haplotypes")); }
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public List<VCFInfoHeaderLine> getDescriptions() { return Arrays.asList(new VCFInfoHeaderLine("HaplotypeScore", 1, VCFHeaderLineType.Float, "Consistency of the site with two (and only two) segregating haplotypes")); }
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@ -0,0 +1,76 @@
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/*
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* Copyright (c) 2010, The Broad Institute
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*
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* Permission is hereby granted, free of charge, to any person
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* obtaining a copy of this software and associated documentation
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* files (the "Software"), to deal in the Software without
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* restriction, including without limitation the rights to use,
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* copy, modify, merge, publish, distribute, sublicense, and/or sell
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* copies of the Software, and to permit persons to whom the
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* Software is furnished to do so, subject to the following
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* conditions:
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*
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* The above copyright notice and this permission notice shall be
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* included in all copies or substantial portions of the Software.
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* THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
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* EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
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* OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
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* NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
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* HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
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* WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
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* FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR
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* OTHER DEALINGS IN THE SOFTWARE.
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*/
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package org.broadinstitute.sting.utils.genotype;
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import java.util.Arrays;
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public class Haplotype {
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protected byte[] bases = null;
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protected double[] quals = null;
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/**
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* Create a simple consensus sequence with provided bases and a uniform quality over all bases of qual
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*
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* @param bases bases
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* @param qual qual
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*/
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public Haplotype(byte[] bases, int qual) {
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this.bases = bases;
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quals = new double[bases.length];
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Arrays.fill(quals, (double)qual);
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}
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public Haplotype(byte[] bases, double[] quals) {
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this.bases = bases;
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this.quals = quals;
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}
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public Haplotype(String bases, double[] quals) {
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this.bases = bases.getBytes();
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this.quals = quals;
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}
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public Haplotype(byte[] bases) {
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this(bases, 0);
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}
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public String toString() { return new String(this.bases); }
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public double getQualitySum() {
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double s = 0;
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for (int k=0; k < bases.length; k++) {
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s += quals[k];
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}
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return s;
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}
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public double[] getQuals() {
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return quals;
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}
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public byte[] getBasesAsBytes() {
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return bases;
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}
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}
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