Initial commit of a burden testing framework. Currently tests against only one phenotype and only one weighting function, but computes robust weighted dosages and calls into an R script that calculates both a direct glm LRT and an asymptotic normal p-values. Weights currently read in from external file (beta-values). Future work is to let these be calculated on the fly from e.g. annotation, potential impact, conservation, etc, and enable multiple weighting schemes tested jointly for association against multiple phenotypes.

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Christopher Hartl 2012-05-21 16:56:32 -04:00

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