Pooled EM SNP Rod converted over to the Variation interface

git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@1719 348d0f76-0448-11de-a6fe-93d51630548a
This commit is contained in:
aaron 2009-09-24 16:33:11 +00:00
parent 97105ac001
commit d2af26e81f
1 changed files with 89 additions and 15 deletions

View File

@ -1,19 +1,7 @@
package org.broadinstitute.sting.gatk.refdata;
import java.util.*;
import java.util.regex.MatchResult;
import java.util.regex.Pattern;
import java.util.regex.Matcher;
import java.io.File;
import java.io.FileNotFoundException;
import java.io.IOException;
import org.broadinstitute.sting.gatk.refdata.ReferenceOrderedDatum;
import org.broadinstitute.sting.utils.GenomeLoc;
import org.broadinstitute.sting.utils.Utils;
import org.broadinstitute.sting.utils.xReadLines;
import org.broadinstitute.sting.utils.cmdLine.Argument;
import org.apache.log4j.Logger;
import java.util.ArrayList;
import java.util.List;
/**
* loc ref alt EM_alt_freq discovery_likelihood discovery_null discovery_prior discovery_lod EM_N n_ref n_het n_hom
@ -22,7 +10,7 @@ import org.apache.log4j.Logger;
* chr1:1104842 A N 0.000000 -84.816002 -84.816002 0.000000 0.000000 324.000000 162 0 0
*
*/
public class PooledEMSNPROD extends TabularROD implements SNPCallFromGenotypes {
public class PooledEMSNPROD extends TabularROD implements SNPCallFromGenotypes, VariationRod {
public PooledEMSNPROD(final String name) {
super(name);
}
@ -33,10 +21,85 @@ public class PooledEMSNPROD extends TabularROD implements SNPCallFromGenotypes {
public String getAltBasesFWD() { return this.get("alt"); }
public char getAltSnpFWD() throws IllegalStateException { return getAltBasesFWD().charAt(0); }
public boolean isReference() { return getVariationConfidence() < 0.01; }
/**
* gets the alternate base. Use this method if we're biallelic
*
* @return
*/
@Override
public String getAlternateBase() {
return getAltBasesFWD();
}
/**
* gets the alternate bases. Use this method if the allele count is greater then 2
*
* @return
*/
@Override
public List<String> getAlternateBases() {
List<String> str = new ArrayList<String>();
str.add(this.getAltBasesFWD());
return str;
}
/**
* get the frequency of this variant
*
* @return VariantFrequency with the stored frequency
*/
@Override
public double getNonRefAlleleFrequency() {
return this.getMAF();
}
/** @return the VARIANT_TYPE of the current variant */
@Override
public VARIANT_TYPE getType() {
if (isSNP()) {
return VARIANT_TYPE.SNP;
}
return VARIANT_TYPE.REFERENCE;
}
public boolean isSNP() { return ! isReference(); }
public boolean isInsertion() { return false; }
public boolean isDeletion() { return false; }
/**
* get the reference base(s) at this position
*
* @return the reference base or bases, as a string
*/
@Override
public String getReference() {
return this.get("ref");
}
public boolean isIndel() { return false; }
/**
* gets the alternate base is the case of a SNP. Throws an IllegalStateException if we're not a SNP
* of
*
* @return a char, representing the alternate base
*/
@Override
public char getAlternativeBaseForSNP() {
return this.getAltSnpFWD();
}
/**
* gets the reference base is the case of a SNP. Throws an IllegalStateException if we're not a SNP
*
* @return a char, representing the alternate base
*/
@Override
public char getReferenceForSNP() {
return this.getRefSnpFWD();
}
public double getMAF() { return Double.parseDouble(this.get("EM_alt_freq")); }
public double getHeterozygosity() { return 2 * getMAF() * (1 - getMAF()); }
public boolean isGenotype() { return false; }
@ -45,6 +108,17 @@ public class PooledEMSNPROD extends TabularROD implements SNPCallFromGenotypes {
public List<String> getGenotype() throws IllegalStateException { throw new IllegalStateException(); }
public int getPloidy() throws IllegalStateException { return 2; }
public boolean isBiallelic() { return true; }
/**
* get the -1 * (log 10 of the error value)
*
* @return the log based error estimate
*/
@Override
public double getNegLog10PError() {
return this.getVariationConfidence();
}
public int length() { return 1; }
// SNPCallFromGenotypes interface