Created a new tool, SiblingIBD, which finds Identical-By-Descent regions in two siblings.

-When parental genotypes are available, implements an HMM on genotype observations in the quartet.
   -Outputs IBD regions as well as per-site posterior probabilities of being in each IBD state.
   -Includes an experimental heuristic based mode for when parental genotypes are not available.
   -Made a method in MendelianViolation public static to reuse code.
   -Added the mockito library to private/gatk-tools-private/pom.xml
This commit is contained in:
Chris Whelan 2014-05-07 10:10:52 -04:00
parent fbc75c8e14
commit ba1d23e535
1 changed files with 9 additions and 1 deletions

View File

@ -373,7 +373,15 @@ public class MendelianViolation {
}
}
private boolean isViolation(Genotype gMom, Genotype gDad, Genotype gChild) {
/**
* Evaluate the genotypes of mom, dad, and child to detect Mendelian violations
*
* @param gMom
* @param gDad
* @param gChild
* @return true if the three genotypes represent a Mendelian violation; false otherwise
*/
public static boolean isViolation(final Genotype gMom, final Genotype gDad, final Genotype gChild) {
//1 parent is no "call
if(!gMom.isCalled()){
return (gDad.isHomRef() && gChild.isHomVar()) || (gDad.isHomVar() && gChild.isHomRef());