From 38740b0ff5e70df6c5d760251d129ed22d0eeccb Mon Sep 17 00:00:00 2001
From: "Mark A. DePristo" <depristo@broadinstitute.org>
Date: Mon, 4 Jul 2011 16:11:42 -0400
Subject: [PATCH 03/59] First working version of the DiffNode readers for VCF
 and BAM files.  Unit tests confirm the readers are approximately working. 
 Skeleton of a working DiffObjects walker that will be able to provide
 detailed information about how exactly two files of the same type differ, so
 long as the files are supported by the DiffNode structure.

---
 public/testdata/diffTestMaster.vcf | 11 +++++++++++
 public/testdata/diffTestTest.vcf   | 11 +++++++++++
 2 files changed, 22 insertions(+)
 create mode 100644 public/testdata/diffTestMaster.vcf
 create mode 100644 public/testdata/diffTestTest.vcf

diff --git a/public/testdata/diffTestMaster.vcf b/public/testdata/diffTestMaster.vcf
new file mode 100644
index 000000000..549f54345
--- /dev/null
+++ b/public/testdata/diffTestMaster.vcf
@@ -0,0 +1,11 @@
+##fileformat=VCFv4.0
+#CHROM	POS	ID	REF	ALT	QUAL	FILTER	INFO	FORMAT	NA12878	
+chr1	2646	rs62635284	G	A	0.15	PASS	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	1/1:53,75:3:-12.40,-0.90,-0.00:9.03
+chr1	2979	rs62635286	T	G	83.67	PASS	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	1/1:31,32:9:-33.61,-2.71,-0.00:27.09
+chr1	2981	rs62028691	A	G	14.69	PASS	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	1/1:31,33:9:-32.12,-2.71,-0.00:27.08
+chr1	4536	rs11582131	G	C	0.18	PASS	AC=1;AF=0.50;AN=2	GT:AD:DP:GL:GQ	0/1:42,33:16:-41.67,-4.82,-26.29:99
+chr1	4562	rs11490464	C	G	0.14	PASS	AC=1;AF=0.50;AN=2	GT:AD:DP:GL:GQ	0/1:26,30:9:-19.64,-2.72,-14.87:99
+chr1	4770	rs6682375	A	G	0.32	PASS	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	1/1:9,111:84:-306.27,-28.58,-3.46:99
+chr1	4793	rs6682385	A	G	0.15	PASS	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	1/1:4,115:109:-350.74,-32.88,-0.10:99
+chr1	5074	rs11586607	T	G	0.01	PASS	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	1/1:29,97:39:-130.41,-11.75,-3.82:79.31
+chr1	5137	rs62636497	A	T	140.49	PASS	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	1/1:0,74:39:-148.99,-11.75,-0.01:99
diff --git a/public/testdata/diffTestTest.vcf b/public/testdata/diffTestTest.vcf
new file mode 100644
index 000000000..8699ab253
--- /dev/null
+++ b/public/testdata/diffTestTest.vcf
@@ -0,0 +1,11 @@
+##fileformat=VCFv4.0
+#CHROM	POS	ID	REF	ALT	QUAL	FILTER	INFO	FORMAT	NA12878	
+chr1	2646	rs62635284	G	A	0.15	PASS	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	1/1:53,75:3:-12.40,-0.90,-0.00:9.03
+chr1	2979	rs62635286	T	G	83.67	CHANGED_FILTER	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	1/1:31,32:9:-33.61,-2.71,-0.00:27.09
+chr1	2981	rs62028691	A	G	14.69	PASS	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	1/1:31,33:9:-32.12,-2.71,-0.00:27.08
+chr1	4536	rs11582131	G	C	0.18	PASS	AC=2;AF=0.50;AN=2	GT:AD:DP:GL:GQ	0/1:42,33:16:-41.67,-4.82,-26.29:99
+chr1	4562	rs11490464	C	G	0.14	PASS	AC=1;AF=0.50;AN=2	GT:AD:DP:GL:GQ	1/1:26,30:9:-19.64,-2.72,-14.87:99
+chr1	4770	rs6682375	A	G	0.32	PASS	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	0/1:9,111:84:-306.27,-28.58,-3.46:99
+chr1	4793	rs6682385	A	G	0.15	PASS	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	1/1:4,114:109:-350.74,-32.88,-0.10:99
+chr1	5074	rs11586607	T	G	0.01	PASS	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	1/1:29,97:39:-130.41,-11.74,-3.82:79.31
+chr1	5137	rs62636497	A	T	140.49	PASS	AC=2;AF=1.00;AN=2	GT:AD:DP:GL:GQ	1/1:0,74:39:-148.99,-11.75,-0.01:9

From 080875d5daf876ebd29b059c156890d7c349983f Mon Sep 17 00:00:00 2001
From: "Mark A. DePristo" <depristo@broadinstitute.org>
Date: Tue, 5 Jul 2011 16:13:39 -0400
Subject: [PATCH 15/59] Refactored DiffNode/DiffElement/DiffValue class
 structure.  DiffElement is now a pair of Name -> Value, where value is either
 a DiffValue or its subclass DiffNode.  Code cleaned up, more tests added. 
 DiffEngine is now working, with tests.  DiffObjectWalker can now take two
 VCFs and itemize the difference between the two files correctly and
 concisely.

---
 build.xml | 4 ++--
 1 file changed, 2 insertions(+), 2 deletions(-)

diff --git a/build.xml b/build.xml
index fe1723587..21066686f 100644
--- a/build.xml
+++ b/build.xml
@@ -741,8 +741,8 @@
                 <jvmarg value="-Dpipeline.run=${pipeline.run}" />
                 <jvmarg value="-Djava.io.tmpdir=${java.io.tmpdir}" />
                 <!-- needs to be if -->
-                <!--jvmarg value="-javaagent:lib/cofoja.jar"/-->
-                <!--jvmarg value="-Dcom.google.java.contract.log.contract=false"/-->
+<!--                 <jvmarg value="-javaagent:lib/cofoja.jar"/> -->
+<!--                 <jvmarg value="-Dcom.google.java.contract.log.contract=false"/> -->
 <!--                 <jvmarg value="-Xdebug"/> -->
 <!--                 <jvmarg value="-Xrunjdwp:transport=dt_socket,server=y,suspend=y,address=5005"/> -->
                 <classpath>

From 7d3dfdfdf2e92f502c4394d338ca01c5de6287e5 Mon Sep 17 00:00:00 2001
From: Mauricio Carneiro <carneiro@broadinstitute.org>
Date: Tue, 5 Jul 2011 16:30:10 -0400
Subject: [PATCH 16/59] Updating the MDCP to use the classpath for the GATK
 jar, removing -gatk parameter.

---
 .../queue/qscripts/MethodsDevelopmentCallingPipeline.scala    | 4 ----
 1 file changed, 4 deletions(-)

diff --git a/public/scala/qscript/org/broadinstitute/sting/queue/qscripts/MethodsDevelopmentCallingPipeline.scala b/public/scala/qscript/org/broadinstitute/sting/queue/qscripts/MethodsDevelopmentCallingPipeline.scala
index d71c6ae5d..f5b639185 100755
--- a/public/scala/qscript/org/broadinstitute/sting/queue/qscripts/MethodsDevelopmentCallingPipeline.scala
+++ b/public/scala/qscript/org/broadinstitute/sting/queue/qscripts/MethodsDevelopmentCallingPipeline.scala
@@ -19,9 +19,6 @@ import org.broadinstitute.sting.gatk.phonehome.GATKRunReport
 class MethodsDevelopmentCallingPipeline extends QScript {
   qscript =>
 
-  @Argument(shortName="gatk", doc="gatk jar file", required=true)
-  var gatkJarFile: File = _
-
   @Argument(shortName="outputDir", doc="output directory", required=true)
   var outputDir: String = "./"
 
@@ -185,7 +182,6 @@ class MethodsDevelopmentCallingPipeline extends QScript {
 
   trait UNIVERSAL_GATK_ARGS extends CommandLineGATK {
     logging_level = "INFO";
-    jarFile = gatkJarFile;
     memoryLimit = 4;
     phone_home = if ( LOCAL_ET ) GATKRunReport.PhoneHomeOption.STANDARD else GATKRunReport.PhoneHomeOption.AWS_S3
   }

From 5298e3a942be54c05a8d765c7aaca99e9c061f8a Mon Sep 17 00:00:00 2001
From: Mauricio Carneiro <carneiro@broadinstitute.org>
Date: Tue, 5 Jul 2011 16:30:41 -0400
Subject: [PATCH 17/59] Making the outputDir optional. Default = ./

---
 .../queue/qscripts/MethodsDevelopmentCallingPipeline.scala      | 2 +-
 1 file changed, 1 insertion(+), 1 deletion(-)

diff --git a/public/scala/qscript/org/broadinstitute/sting/queue/qscripts/MethodsDevelopmentCallingPipeline.scala b/public/scala/qscript/org/broadinstitute/sting/queue/qscripts/MethodsDevelopmentCallingPipeline.scala
index f5b639185..a961beca1 100755
--- a/public/scala/qscript/org/broadinstitute/sting/queue/qscripts/MethodsDevelopmentCallingPipeline.scala
+++ b/public/scala/qscript/org/broadinstitute/sting/queue/qscripts/MethodsDevelopmentCallingPipeline.scala
@@ -19,7 +19,7 @@ import org.broadinstitute.sting.gatk.phonehome.GATKRunReport
 class MethodsDevelopmentCallingPipeline extends QScript {
   qscript =>
 
-  @Argument(shortName="outputDir", doc="output directory", required=true)
+  @Argument(shortName="outputDir", doc="output directory", required=false)
   var outputDir: String = "./"
 
   @Argument(shortName="skipCalling", doc="skip the calling part of the pipeline and only run VQSR on preset, gold standard VCF files", required=false)

From 7b699f8b175f02bbf7ba2cb1aea420361dc4af0d Mon Sep 17 00:00:00 2001
From: Khalid Shakir <kshakir@broadinstitute.org>
Date: Tue, 5 Jul 2011 21:59:00 -0400
Subject: [PATCH 18/59] Switched GridEngine from looking from environment
 variable to using embedded jar.

---
 build.xml                                     |  33 ++++++++----------
 ivy.xml                                       |   3 ++
 settings/ivysettings.xml                      |   1 +
 .../drmaa-6.2u5p2-sources.jar                 | Bin 0 -> 110692 bytes
 .../net.sf.gridscheduler/drmaa-6.2u5p2.jar    | Bin 0 -> 51479 bytes
 .../net.sf.gridscheduler/drmaa-6.2u5p2.xml    |   3 ++
 6 files changed, 21 insertions(+), 19 deletions(-)
 create mode 100644 settings/repository/net.sf.gridscheduler/drmaa-6.2u5p2-sources.jar
 create mode 100644 settings/repository/net.sf.gridscheduler/drmaa-6.2u5p2.jar
 create mode 100644 settings/repository/net.sf.gridscheduler/drmaa-6.2u5p2.xml

diff --git a/build.xml b/build.xml
index fe1723587..a78c4d738 100644
--- a/build.xml
+++ b/build.xml
@@ -69,8 +69,6 @@
 
     <property environment="env"/>
 
-    <property name="drmaa.jar" value="${env.SGE_ROOT}/lib/drmaa.jar" />
-
     <patternset id="java.source.pattern">
         <include name="${java.public.source.dir}/**/*.java" />
         <include name="${java.private.source.dir}/**/*.java" if="include.private" />
@@ -146,11 +144,7 @@
         <property name="init.resolve.done" value="true"/>
     </target>
 
-    <target name="init.gridengine" depends="init" if="include.gridengine">
-        <copy todir="lib" file="${drmaa.jar}"/>
-    </target>
-
-    <target name="resolve" depends="init.resolve,init,init.gridengine"
+    <target name="resolve" depends="init.resolve,init"
             description="locate and download library dependencies">
         <property name="ivy.conf" value="default"/>
       <ivy:retrieve file="ivy.xml" conf="${ivy.conf}" />
@@ -178,13 +172,23 @@
         <property name="build.version" value="${git.describe.output}" />
     </target>
     
-    <target name="untagged.build.version" depends="git.describe" unless="git.describe.succeeded">
-      <exec executable="git" outputproperty="build.version" failonerror="true">
+    <target name="git.rev-parse" depends="git.describe" unless="git.describe.succeeded">
+      <exec executable="git" outputproperty="git.rev-parse.output" resultproperty="git.rev-parse.exit.value" failonerror="false">
         <arg line="rev-parse HEAD" />
       </exec>
+      <condition property="git.rev-parse.succeeded">
+        <equals arg1="${git.rev-parse.exit.value}" arg2="0" />
+      </condition>
     </target>
     
-    <target name="generate.build.version" depends="tagged.build.version, untagged.build.version" />
+    <target name="untagged.build.version" depends="git.rev-parse" if="git.rev-parse.succeeded">
+        <property name="build.version" value="${git.rev-parse.output}" />
+    </target>
+    
+    <target name="generate.build.version" depends="tagged.build.version, untagged.build.version">
+        <!-- Set build.version to exported if no other value has been set -->
+        <property name="build.version" value="exported" />
+    </target>
 
     <!-- define some key locations that might change based on how the build is run -->
     <target name="init" depends="generate.build.version">
@@ -214,12 +218,6 @@
             </or>
         </condition>
 
-        <!-- Include Grid Engine in the compile if SGE_ROOT is available. -->
-        <!-- Based off of http://wikis.sun.com/display/GridEngine/Automating+Grid+Engine+Functions+Through+DRMAA -->
-        <condition property="include.gridengine">
-            <available file="${drmaa.jar}"/>
-        </condition>
-
         <echo message="GATK build      : ${gatk.target}"/>
         <echo message="Scala build     : ${scala.target}"/>
       <echo message="source revision : ${build.version}"/>
@@ -357,7 +355,6 @@
             <src path="${scala.public.source.dir}" />
             <src path="${queue-extensions.source.dir}" />
             <include name="**/*.scala"/>
-            <exclude name="**/gridengine/**" unless="include.gridengine" />
         </scalac>    
     </target>
     
@@ -374,7 +371,6 @@
         <scalac fork="true" jvmargs="-Xmx512m" destdir="${scala.classes}" classpathref="scala.dependencies" deprecation="yes" unchecked="yes">
             <src path="${scala.private.source.dir}" />
             <include name="**/*.scala"/>
-            <exclude name="**/gridengine/**" unless="include.gridengine" />
         </scalac>       
     </target>
 
@@ -682,7 +678,6 @@
 	        <src path="${scala.public.test.sources}" />
 	        <src path="${scala.private.test.sources}" />
             <include name="**/*.scala"/>
-            <exclude name="**/gridengine/**" unless="include.gridengine" />
             <classpath>
                 <path refid="scala.dependencies"/>
                 <pathelement location="${scala.test.classes}"/>
diff --git a/ivy.xml b/ivy.xml
index c2a6c4ccd..10e4ee570 100644
--- a/ivy.xml
+++ b/ivy.xml
@@ -48,6 +48,9 @@
     <!-- Dependencies for amazon.com S3 support -->
     <dependency org="net.java.dev.jets3t" name="jets3t" rev="0.8.0"/>
 
+    <!-- Dependencies for GridEngine -->
+    <dependency org="net.sf.gridscheduler" name="drmaa" rev="latest.integration"/>
+
     <!-- Scala dependancies -->
     <dependency org="org.scala-lang" name="scala-compiler" rev="2.8.1"/>
     <dependency org="org.scala-lang" name="scala-library" rev="2.8.1"/>
diff --git a/settings/ivysettings.xml b/settings/ivysettings.xml
index 1e47fa847..2c8fc388f 100644
--- a/settings/ivysettings.xml
+++ b/settings/ivysettings.xml
@@ -25,5 +25,6 @@
     <module organisation="javax.activation" resolver="java.net" />
     <module organisation="net.java.dev.jna" resolver="maven2-repository.dev.java.net" />
     <module organisation="com.google.code.caliper" resolver="projects" />
+    <module organisation="net.sf.gridscheduler" resolver="projects" />
   </modules>
 </ivysettings>
diff --git a/settings/repository/net.sf.gridscheduler/drmaa-6.2u5p2-sources.jar b/settings/repository/net.sf.gridscheduler/drmaa-6.2u5p2-sources.jar
new file mode 100644
index 0000000000000000000000000000000000000000..dc77c7d333c61a79fa8c7be7d8ad3345678f811c
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diff --git a/settings/repository/net.sf.gridscheduler/drmaa-6.2u5p2.jar b/settings/repository/net.sf.gridscheduler/drmaa-6.2u5p2.jar
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z!`Q(e0_Y<Cw}9Vk`JoT{54^L)f8YUr>(TzOix18GKOo5}{{i`bGx|Ri@zARMLqtN=
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literal 0
HcmV?d00001

diff --git a/settings/repository/net.sf.gridscheduler/drmaa-6.2u5p2.xml b/settings/repository/net.sf.gridscheduler/drmaa-6.2u5p2.xml
new file mode 100644
index 000000000..c6a8da052
--- /dev/null
+++ b/settings/repository/net.sf.gridscheduler/drmaa-6.2u5p2.xml
@@ -0,0 +1,3 @@
+<ivy-module version="1.0">
+    <info organisation="net.sf.gridscheduler" module="drmaa" revision="6.2u5p2" status="release" />
+</ivy-module>

From 81a4d18468b85b8cdc79e6f9d06c735f5ca16d9b Mon Sep 17 00:00:00 2001
From: Guillermo del Angel <delangel@broadinstitute.org>
Date: Wed, 6 Jul 2011 09:56:38 -0400
Subject: [PATCH 20/59] Mark several indel-related arguments as @Hidden

---
 .../gatk/walkers/genotyper/UnifiedArgumentCollection.java | 8 +++++++-
 1 file changed, 7 insertions(+), 1 deletion(-)

diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedArgumentCollection.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedArgumentCollection.java
index 1045ca371..055eb0b97 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedArgumentCollection.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedArgumentCollection.java
@@ -92,25 +92,31 @@ public class UnifiedArgumentCollection {
     @Argument(fullName = "indel_heterozygosity", shortName = "indelHeterozygosity", doc = "Heterozygosity for indel calling", required = false)
     public double INDEL_HETEROZYGOSITY = 1.0/8000;
 
+    @Hidden
     @Argument(fullName = "indelGapContinuationPenalty", shortName = "indelGCP", doc = "Indel gap continuation penalty", required = false)
     public double INDEL_GAP_CONTINUATION_PENALTY = 10.0;
 
+    @Hidden
     @Argument(fullName = "indelGapOpenPenalty", shortName = "indelGOP", doc = "Indel gap open penalty", required = false)
     public double INDEL_GAP_OPEN_PENALTY = 45.0;
 
+    @Hidden
     @Argument(fullName = "indelHaplotypeSize", shortName = "indelHSize", doc = "Indel haplotype size", required = false)
     public int INDEL_HAPLOTYPE_SIZE = 80;
+    @Hidden
     @Argument(fullName = "doContextDependentGapPenalties", shortName = "doCDP", doc = "Vary gap penalties by context", required = false)
      public boolean DO_CONTEXT_DEPENDENT_PENALTIES = true;
     //gdebug+
-    @Hidden
     // experimental arguments, NOT TO BE USED BY ANYONE WHOSE INITIALS AREN'T GDA!!!
+    @Hidden
     @Argument(fullName = "getGapPenaltiesFromData", shortName = "dataGP", doc = "Vary gap penalties by context - EXPERIMENTAL, DO NO USE", required = false)
     public boolean GET_GAP_PENALTIES_FROM_DATA = false;
 
+    @Hidden
     @Argument(fullName="indel_recal_file", shortName="recalFile", required=false, doc="Filename for the input covariates table recalibration .csv file - EXPERIMENTAL, DO NO USE")
     public File INDEL_RECAL_FILE = new File("indel.recal_data.csv");
 
+    @Hidden
     @Argument(fullName = "indelDebug", shortName = "indelDebug", doc = "Output indel debug info", required = false)
     public boolean OUTPUT_DEBUG_INDEL_INFO = false;
     @Hidden

From e8ed6b7f0f1c3e0e4f75d77349807b36ee37a3c7 Mon Sep 17 00:00:00 2001
From: Ryan Poplin <rpoplin@broadinstitute.org>
Date: Wed, 6 Jul 2011 10:01:14 -0400
Subject: [PATCH 21/59] Adding more comments to main VQSR walker. Fixing
 copyright lines. Bug fix for default paths to now point to public/R/ instead
 of R/  Bug fix in VQSR for the path to the R scripts not ending in a slash.

---
 .../analyzecovariates/AnalyzeCovariates.java  |  2 +-
 .../ApplyRecalibration.java                   |  2 +-
 .../GaussianMixtureModel.java                 | 25 ++++++++++++++++++
 .../MultivariateGaussian.java                 | 25 ++++++++++++++++++
 .../variantrecalibration/TrainingSet.java     | 25 ++++++++++++++++++
 .../walkers/variantrecalibration/Tranche.java |  2 +-
 .../variantrecalibration/TrancheManager.java  | 25 ++++++++++++++++++
 .../VQSRCalibrationCurve.java                 | 26 ++++++++++++++++++-
 .../VariantDataManager.java                   | 25 ++++++++++++++++++
 .../variantrecalibration/VariantDatum.java    | 25 ++++++++++++++++++
 .../VariantRecalibrator.java                  | 15 ++++++++---
 ...VariantRecalibratorArgumentCollection.java | 25 ++++++++++++++++++
 .../VariantRecalibratorEngine.java            | 25 ++++++++++++++++++
 13 files changed, 239 insertions(+), 8 deletions(-)

diff --git a/public/java/src/org/broadinstitute/sting/analyzecovariates/AnalyzeCovariates.java b/public/java/src/org/broadinstitute/sting/analyzecovariates/AnalyzeCovariates.java
index 3cf43c15a..f8e298d88 100755
--- a/public/java/src/org/broadinstitute/sting/analyzecovariates/AnalyzeCovariates.java
+++ b/public/java/src/org/broadinstitute/sting/analyzecovariates/AnalyzeCovariates.java
@@ -61,7 +61,7 @@ public class AnalyzeCovariates extends CommandLineProgram {
     @Argument(fullName = "path_to_Rscript", shortName = "Rscript", doc = "The path to your implementation of Rscript. For Broad users this is maybe /broad/tools/apps/R-2.6.0/bin/Rscript", required = false)
     private String PATH_TO_RSCRIPT = "Rscript";
     @Argument(fullName = "path_to_resources", shortName = "resources", doc = "Path to resources folder holding the Sting R scripts.", required = false)
-    private String PATH_TO_RESOURCES = "R/";
+    private String PATH_TO_RESOURCES = "public/R/";
     @Argument(fullName = "ignoreQ", shortName = "ignoreQ", doc = "Ignore bases with reported quality less than this number.", required = false)
     private int IGNORE_QSCORES_LESS_THAN = 5;
     @Argument(fullName = "numRG", shortName = "numRG", doc = "Only process N read groups. Default value: -1 (process all read groups)", required = false)            
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/ApplyRecalibration.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/ApplyRecalibration.java
index 9877781d1..7957d35cd 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/ApplyRecalibration.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/ApplyRecalibration.java
@@ -1,5 +1,5 @@
 /*
- * Copyright (c) 2010 The Broad Institute
+ * Copyright (c) 2011 The Broad Institute
  *
  * Permission is hereby granted, free of charge, to any person
  * obtaining a copy of this software and associated documentation
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/GaussianMixtureModel.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/GaussianMixtureModel.java
index 9ffe7be7a..acc1f24cc 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/GaussianMixtureModel.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/GaussianMixtureModel.java
@@ -1,3 +1,28 @@
+/*
+ * Copyright (c) 2011 The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ *
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR
+ * THE USE OR OTHER DEALINGS IN THE SOFTWARE.
+ */
+
 package org.broadinstitute.sting.gatk.walkers.variantrecalibration;
 
 import Jama.Matrix;
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/MultivariateGaussian.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/MultivariateGaussian.java
index 0b2edfd10..d077af78e 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/MultivariateGaussian.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/MultivariateGaussian.java
@@ -1,3 +1,28 @@
+/*
+ * Copyright (c) 2011 The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ *
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR
+ * THE USE OR OTHER DEALINGS IN THE SOFTWARE.
+ */
+
 package org.broadinstitute.sting.gatk.walkers.variantrecalibration;
 
 import Jama.Matrix;
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/TrainingSet.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/TrainingSet.java
index f3677421e..67132b133 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/TrainingSet.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/TrainingSet.java
@@ -1,3 +1,28 @@
+/*
+ * Copyright (c) 2011 The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ *
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR
+ * THE USE OR OTHER DEALINGS IN THE SOFTWARE.
+ */
+
 package org.broadinstitute.sting.gatk.walkers.variantrecalibration;
 
 import org.apache.log4j.Logger;
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/Tranche.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/Tranche.java
index fbee64fe2..64fe36637 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/Tranche.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/Tranche.java
@@ -1,5 +1,5 @@
 /*
- * Copyright (c) 2010 The Broad Institute
+ * Copyright (c) 2011 The Broad Institute
  *
  * Permission is hereby granted, free of charge, to any person
  * obtaining a copy of this software and associated documentation
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/TrancheManager.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/TrancheManager.java
index 08388db21..19c6d501b 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/TrancheManager.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/TrancheManager.java
@@ -1,3 +1,28 @@
+/*
+ * Copyright (c) 2011 The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ *
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR
+ * THE USE OR OTHER DEALINGS IN THE SOFTWARE.
+ */
+
 package org.broadinstitute.sting.gatk.walkers.variantrecalibration;
 
 import org.apache.log4j.Logger;
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VQSRCalibrationCurve.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VQSRCalibrationCurve.java
index 2914385a4..5deb5d8c2 100644
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VQSRCalibrationCurve.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VQSRCalibrationCurve.java
@@ -1,8 +1,32 @@
+/*
+ * Copyright (c) 2011 The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ *
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR
+ * THE USE OR OTHER DEALINGS IN THE SOFTWARE.
+ */
+
 package org.broadinstitute.sting.gatk.walkers.variantrecalibration;
 
 import org.apache.log4j.Logger;
 import org.broadinstitute.sting.utils.variantcontext.VariantContext;
-import org.broadinstitute.sting.gatk.walkers.varianteval.evaluators.VariantQualityScore;
 import org.broadinstitute.sting.utils.exceptions.ReviewedStingException;
 import org.broadinstitute.sting.utils.exceptions.UserException;
 import org.broadinstitute.sting.utils.text.XReadLines;
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDataManager.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDataManager.java
index 2fd1326fe..f0a78280d 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDataManager.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDataManager.java
@@ -1,3 +1,28 @@
+/*
+ * Copyright (c) 2011 The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ *
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR
+ * THE USE OR OTHER DEALINGS IN THE SOFTWARE.
+ */
+
 package org.broadinstitute.sting.gatk.walkers.variantrecalibration;
 
 import cern.jet.random.Normal;
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDatum.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDatum.java
index ac875b645..8295ec205 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDatum.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDatum.java
@@ -1,3 +1,28 @@
+/*
+ * Copyright (c) 2011 The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ *
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR
+ * THE USE OR OTHER DEALINGS IN THE SOFTWARE.
+ */
+
 package org.broadinstitute.sting.gatk.walkers.variantrecalibration;
 
 /**
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibrator.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibrator.java
index e651b62e0..a77c5962c 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibrator.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibrator.java
@@ -87,7 +87,7 @@ public class VariantRecalibrator extends RodWalker<ExpandingArrayList<VariantDat
     @Argument(fullName="rscript_file", shortName="rscriptFile", doc="The output rscript file generated by the VQSR to aid in visualization of the input data and learned model", required=false)
     private String RSCRIPT_FILE = null;
     @Argument(fullName = "path_to_resources", shortName = "resources", doc = "Path to resources folder holding the Sting R scripts.", required=false)
-    private String PATH_TO_RESOURCES = "R/";
+    private String PATH_TO_RESOURCES = "public/R/";
     @Argument(fullName="ts_filter_level", shortName="ts_filter_level", doc="The truth sensitivity level at which to start filtering, used here to indicate filtered variants in plots", required=false)
     private double TS_FILTER_LEVEL = 99.0;
 
@@ -117,6 +117,7 @@ public class VariantRecalibrator extends RodWalker<ExpandingArrayList<VariantDat
     //---------------------------------------------------------------------------------------------------------------
 
     public void initialize() {
+        if( !PATH_TO_RESOURCES.endsWith("/") ) { PATH_TO_RESOURCES = PATH_TO_RESOURCES + "/"; }
         dataManager = new VariantDataManager( new ArrayList<String>(Arrays.asList(USE_ANNOTATIONS)), VRAC );
 
         if( IGNORE_INPUT_FILTERS != null ) {
@@ -228,18 +229,22 @@ public class VariantRecalibrator extends RodWalker<ExpandingArrayList<VariantDat
     public void onTraversalDone( final ExpandingArrayList<VariantDatum> reduceSum ) {
         dataManager.setData( reduceSum );
         dataManager.normalizeData(); // Each data point is now (x - mean) / standard deviation
+
+        // Generate the positive model using the training data and evaluate each variant
         final GaussianMixtureModel goodModel = engine.generateModel( dataManager.getTrainingData() );
         engine.evaluateData( dataManager.getData(), goodModel, false );
+
+        // Generate the negative model using the worst performing data and evaluate each variant contrastively
         final GaussianMixtureModel badModel = engine.generateModel( dataManager.selectWorstVariants( VRAC.PERCENT_BAD_VARIANTS, VRAC.MIN_NUM_BAD_VARIANTS ) );
         engine.evaluateData( dataManager.getData(), badModel, true );
 
-        final ExpandingArrayList<VariantDatum> randomData = dataManager.getRandomDataForPlotting( 6000 );
-
+        // Find the VQSLOD cutoff values which correspond to the various tranches of calls requested by the user
         final int nCallsAtTruth = TrancheManager.countCallsAtTruth( dataManager.getData(), Double.NEGATIVE_INFINITY );
         final TrancheManager.SelectionMetric metric = new TrancheManager.TruthSensitivityMetric( nCallsAtTruth );
         final List<Tranche> tranches = TrancheManager.findTranches( dataManager.getData(), TS_TRANCHES, metric );
         tranchesStream.print(Tranche.tranchesString( tranches ));
 
+        // Find the filtering lodCutoff for display on the model PDFs. Red variants are those which were below the cutoff and filtered out of the final callset.
         double lodCutoff = 0.0;
         for( final Tranche tranche : tranches ) {
             if( MathUtils.compareDoubles(tranche.ts, TS_FILTER_LEVEL, 0.0001)==0 ) {
@@ -251,7 +256,7 @@ public class VariantRecalibrator extends RodWalker<ExpandingArrayList<VariantDat
         dataManager.writeOutRecalibrationTable( RECAL_FILE );
         if( RSCRIPT_FILE != null ) {
             logger.info( "Writing out visualization Rscript file...");
-            createVisualizationScript( randomData, goodModel, badModel, lodCutoff );
+            createVisualizationScript( dataManager.getRandomDataForPlotting( 6000 ), goodModel, badModel, lodCutoff );
         }
 
         // Execute Rscript command to create the tranche plot
@@ -277,6 +282,8 @@ public class VariantRecalibrator extends RodWalker<ExpandingArrayList<VariantDat
         } catch( FileNotFoundException e ) {
             throw new UserException.CouldNotCreateOutputFile(RSCRIPT_FILE, "", e);
         }
+
+        // We make extensive use of the ggplot2 library: http://had.co.nz/ggplot2/
         stream.println("library(ggplot2)");
 
         createArrangeFunction( stream );
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibratorArgumentCollection.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibratorArgumentCollection.java
index e177cebab..f597fb128 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibratorArgumentCollection.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibratorArgumentCollection.java
@@ -1,3 +1,28 @@
+/*
+ * Copyright (c) 2011 The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ *
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR
+ * THE USE OR OTHER DEALINGS IN THE SOFTWARE.
+ */
+
 package org.broadinstitute.sting.gatk.walkers.variantrecalibration;
 
 import org.broadinstitute.sting.commandline.Argument;
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibratorEngine.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibratorEngine.java
index a0fbc572d..4deb82f6b 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibratorEngine.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibratorEngine.java
@@ -1,3 +1,28 @@
+/*
+ * Copyright (c) 2011 The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ *
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR
+ * THE USE OR OTHER DEALINGS IN THE SOFTWARE.
+ */
+
 package org.broadinstitute.sting.gatk.walkers.variantrecalibration;
 
 import org.apache.log4j.Logger;

From c93d0b37a8334ea2ec0ec0c63008940b7bcc844b Mon Sep 17 00:00:00 2001
From: Khalid Shakir <kshakir@broadinstitute.org>
Date: Wed, 6 Jul 2011 11:32:46 -0400
Subject: [PATCH 22/59] Fixed namespace of the pipeline classes.

---
 build.xml | 2 +-
 1 file changed, 1 insertion(+), 1 deletion(-)

diff --git a/build.xml b/build.xml
index fe1723587..2a23f74c1 100644
--- a/build.xml
+++ b/build.xml
@@ -464,7 +464,7 @@
               <exclude name="**/utils/variantcontext/**/*.class"/>
             </fileset>
             <fileset dir="${java.classes}" includes="**/commandline/**/*.class"/>
-            <fileset dir="${java.classes}" includes="**/sting/datasources/**/*.class"/>
+            <fileset dir="${java.classes}" includes="**/sting/pipeline/**/*.class"/>
             <fileset dir="${java.classes}" includes="**/sting/jna/**/*.class"/>
             <fileset dir="${java.classes}" includes="net/sf/picard/**/*.class"/>
             <fileset dir="${java.classes}" includes="net/sf/samtools/**/*.class"/>

From 14fee4ccbd990bd32956017624dfbcdddeee75ae Mon Sep 17 00:00:00 2001
From: Eric Banks <ebanks@broadinstitute.org>
Date: Wed, 6 Jul 2011 12:51:44 -0400
Subject: [PATCH 26/59] Patch from Bob to deal with symbolic alleles: these
 weren't getting padded but they should be.

---
 .../sting/utils/variantcontext/VariantContext.java  | 13 ++++++++++++-
 1 file changed, 12 insertions(+), 1 deletion(-)

diff --git a/public/java/src/org/broadinstitute/sting/utils/variantcontext/VariantContext.java b/public/java/src/org/broadinstitute/sting/utils/variantcontext/VariantContext.java
index 3d375aba2..5787b591f 100755
--- a/public/java/src/org/broadinstitute/sting/utils/variantcontext/VariantContext.java
+++ b/public/java/src/org/broadinstitute/sting/utils/variantcontext/VariantContext.java
@@ -1343,6 +1343,15 @@ public class VariantContext implements Feature { // to enable tribble intergrati
         return (int)stop;
     }
 
+    private boolean hasSymbolicAlleles() {
+        for (Allele a: getAlleles()) {
+            if (a.isSymbolic()) {
+                return true;
+            }
+        }
+        return false;
+    }
+
     public static VariantContext createVariantContextWithPaddedAlleles(VariantContext inputVC, byte inputRefBase, boolean refBaseShouldBeAppliedToEndOfAlleles) {
         Allele refAllele = inputVC.getReference();
 
@@ -1352,7 +1361,9 @@ public class VariantContext implements Feature { // to enable tribble intergrati
         // We need to pad a VC with a common base if the length of the reference allele is less than the length of the VariantContext.
         // This happens because the position of e.g. an indel is always one before the actual event (as per VCF convention).
         long locLength = (inputVC.getEnd() - inputVC.getStart()) + 1;
-        if (refAllele.length() == locLength)
+        if (inputVC.hasSymbolicAlleles())
+            padVC = true;
+        else if (refAllele.length() == locLength)
             padVC = false;
         else if (refAllele.length() == locLength-1)
             padVC = true;

From 54121eb082eb84920770d573ff143efbe32f0340 Mon Sep 17 00:00:00 2001
From: Eric Banks <ebanks@broadinstitute.org>
Date: Wed, 6 Jul 2011 16:05:08 -0400
Subject: [PATCH 29/59] Catch malformed bams that cause the writer to run in
 infinite loops

---
 .../gatk/walkers/indels/ConstrainedMateFixingManager.java | 8 +++++---
 1 file changed, 5 insertions(+), 3 deletions(-)

diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/indels/ConstrainedMateFixingManager.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/indels/ConstrainedMateFixingManager.java
index aebb0e3eb..df1f4f908 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/indels/ConstrainedMateFixingManager.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/indels/ConstrainedMateFixingManager.java
@@ -5,6 +5,7 @@ import net.sf.samtools.*;
 import org.apache.log4j.Logger;
 import org.broadinstitute.sting.utils.GenomeLoc;
 import org.broadinstitute.sting.utils.GenomeLocParser;
+import org.broadinstitute.sting.utils.exceptions.ReviewedStingException;
 import org.broadinstitute.sting.utils.exceptions.UserException;
 
 import java.util.*;
@@ -113,9 +114,10 @@ public class ConstrainedMateFixingManager {
     HashMap<String, SAMRecordHashObject> forMateMatching = new HashMap<String, SAMRecordHashObject>();
     TreeSet<SAMRecord> waitingReads = new TreeSet<SAMRecord>(comparer);
 
-    private <T> T remove(TreeSet<T> treeSet) {
-        final T first = treeSet.first();
-        treeSet.remove(first);
+    private SAMRecord remove(TreeSet<SAMRecord> treeSet) {
+        final SAMRecord first = treeSet.first();
+        if ( !treeSet.remove(first) )
+            throw new UserException("Error caching SAM record " + first.getReadName() + ", which is usually caused by malformed SAM/BAM files in which multiple identical copies of a read are present.");
         return first;
     }
 

From ccf34f7e45164cea70beccb4cf1b0791e6acde06 Mon Sep 17 00:00:00 2001
From: Mark DePristo <depristo@broadinstitute.org>
Date: Wed, 6 Jul 2011 21:57:22 -0400
Subject: [PATCH 30/59] (1) Added very useful helper class TestDataProvider to
 BaseTest that making creating data providers for TestNG far easier (2)
 DiffEngine now officially working with with summaries.  Extensive UnitTests
 all around!

---
 .../org/broadinstitute/sting/BaseTest.java    | 55 +++++++++++++++++++
 1 file changed, 55 insertions(+)

diff --git a/public/java/test/org/broadinstitute/sting/BaseTest.java b/public/java/test/org/broadinstitute/sting/BaseTest.java
index 61bb8b34b..b469c8a41 100755
--- a/public/java/test/org/broadinstitute/sting/BaseTest.java
+++ b/public/java/test/org/broadinstitute/sting/BaseTest.java
@@ -12,6 +12,10 @@ import java.io.*;
 import java.math.BigInteger;
 import java.security.MessageDigest;
 import java.security.NoSuchAlgorithmException;
+import java.util.ArrayList;
+import java.util.HashMap;
+import java.util.List;
+import java.util.Map;
 
 /**
  *
@@ -107,6 +111,57 @@ public abstract class BaseTest {
         }
     }
 
+    /**
+     * Simple generic utility class to creating TestNG data providers:
+     *
+     * 1: inherit this class, as in
+     *
+     *      private class SummarizeDifferenceTest extends TestDataProvider {
+     *         public SummarizeDifferenceTest() {
+     *           super(SummarizeDifferenceTest.class);
+     *         }
+     *         ...
+     *      }
+     *
+     * Provide a reference to your class to the TestDataProvider constructor.
+     *
+     * 2: Create instances of your subclass.  Return from it the call to getTests, providing
+     * the class type of your test
+     *
+     * @DataProvider(name = "summaries")
+     * public Object[][] createSummaries() {
+     *   new SummarizeDifferenceTest().addDiff("A", "A").addSummary("A:2");
+     *   new SummarizeDifferenceTest().addDiff("A", "B").addSummary("A:1", "B:1");
+     *   return SummarizeDifferenceTest.getTests(SummarizeDifferenceTest.class);
+     * }
+     *
+     * This class magically tracks created objects of this
+     */
+    public static class TestDataProvider {
+        private static final Map<Class, List<Object>> tests = new HashMap<Class, List<Object>>();
+
+        /**
+         * Create a new TestDataProvider instance bound to the class variable C
+         * @param c
+         */
+        public TestDataProvider(Class c) {
+            if ( ! tests.containsKey(c) )
+                tests.put(c, new ArrayList<Object>());
+            tests.get(c).add(this);
+        }
+
+        /**
+         * Return all of the data providers in the form expected by TestNG of type class C
+         * @param c
+         * @return
+         */
+        public static Object[][] getTests(Class c) {
+            List<Object[]> params2 = new ArrayList<Object[]>();
+            for ( Object x : tests.get(c) ) params2.add(new Object[]{x});
+            return params2.toArray(new Object[][]{});
+        }
+    }
+
     /**
      * test if the file exists
      *

From 50111db2b7920ba5b3cfe659e33f7135ebd277f5 Mon Sep 17 00:00:00 2001
From: Ryan Poplin <rpoplin@broadinstitute.org>
Date: Thu, 7 Jul 2011 15:02:48 -0400
Subject: [PATCH 33/59] Fixing non-determinism in single-threaded VQSR by
 moving references to cern.Normal over to the static random generator
 available in GenomeAnalysisEngine

---
 .../GaussianMixtureModel.java                 | 24 ++++++++++---------
 .../VariantDataManager.java                   |  3 +--
 2 files changed, 14 insertions(+), 13 deletions(-)

diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/GaussianMixtureModel.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/GaussianMixtureModel.java
index acc1f24cc..41fea0896 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/GaussianMixtureModel.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/GaussianMixtureModel.java
@@ -26,7 +26,6 @@
 package org.broadinstitute.sting.gatk.walkers.variantrecalibration;
 
 import Jama.Matrix;
-import cern.jet.random.Normal;
 import org.apache.log4j.Logger;
 import org.broadinstitute.sting.gatk.GenomeAnalysisEngine;
 import org.broadinstitute.sting.utils.MathUtils;
@@ -97,7 +96,7 @@ public class GaussianMixtureModel {
 
         int ttt = 0;
         while( ttt++ < numIterations ) {
-            // Estep: assign each variant to the nearest cluster
+            // E step: assign each variant to the nearest cluster
             for( final VariantDatum datum : data ) {
                 double minDistance = Double.MAX_VALUE;
                 MultivariateGaussian minGaussian = null;
@@ -112,7 +111,7 @@ public class GaussianMixtureModel {
                 datum.assignment = minGaussian;
             }
 
-            // Mstep: update gaussian means based on assigned variants
+            // M step: update gaussian means based on assigned variants
             for( final MultivariateGaussian gaussian : gaussians ) {
                 gaussian.zeroOutMu();
                 int numAssigned = 0;
@@ -216,26 +215,29 @@ public class GaussianMixtureModel {
     }
 
     public double evaluateDatumMarginalized( final VariantDatum datum ) {
-        int numVals = 0;
+        int numSamples = 0;
         double sumPVarInGaussian = 0.0;
-        int numIter = 10;
+        final int numIterPerMissingAnnotation = 10; // Trade off here between speed of computation and accuracy of the marginalization
         final double[] pVarInGaussianLog10 = new double[gaussians.size()];
+        // for each dimension
         for( int iii = 0; iii < datum.annotations.length; iii++ ) {
-            // marginalize over the missing dimension by drawing X random values for the missing annotation and averaging the lod
+            // if it is missing marginalize over the missing dimension by drawing X random values for the missing annotation and averaging the lod
             if( datum.isNull[iii] ) {
-                for( int ttt = 0; ttt < numIter; ttt++ ) {
-                    datum.annotations[iii] = Normal.staticNextDouble(0.0, 1.0);
+                for( int ttt = 0; ttt < numIterPerMissingAnnotation; ttt++ ) {
+                    datum.annotations[iii] = GenomeAnalysisEngine.getRandomGenerator().nextGaussian(); // draw a random sample from the standard normal distribution
 
+                    // evaluate this random data point
                     int gaussianIndex = 0;
                     for( final MultivariateGaussian gaussian : gaussians ) {
                         pVarInGaussianLog10[gaussianIndex++] = gaussian.pMixtureLog10 + gaussian.evaluateDatumLog10( datum );
                     }
 
-                    sumPVarInGaussian += Math.pow(10.0, MathUtils.log10sumLog10(pVarInGaussianLog10));
-                    numVals++;
+                    // add this sample's probability to the pile in order to take an average in the end
+                    sumPVarInGaussian += Math.pow(10.0, MathUtils.log10sumLog10(pVarInGaussianLog10)); // p = 10 ^ Sum(pi_k * p(v|n,k))
+                    numSamples++;
                 }
             }
         }
-        return Math.log10( sumPVarInGaussian / ((double) numVals) );
+        return Math.log10( sumPVarInGaussian / ((double) numSamples) );
     }
 }
\ No newline at end of file
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDataManager.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDataManager.java
index f0a78280d..e1a076e76 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDataManager.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDataManager.java
@@ -25,7 +25,6 @@
 
 package org.broadinstitute.sting.gatk.walkers.variantrecalibration;
 
-import cern.jet.random.Normal;
 import org.apache.log4j.Logger;
 import org.broadinstitute.sting.utils.variantcontext.VariantContext;
 import org.broadinstitute.sting.gatk.GenomeAnalysisEngine;
@@ -91,7 +90,7 @@ public class VariantDataManager {
             meanVector[iii] = theMean;
             varianceVector[iii] = theSTD;
             for( final VariantDatum datum : data ) {
-                datum.annotations[iii] = ( datum.isNull[iii] ? Normal.staticNextDouble(0.0, 1.0) : ( datum.annotations[iii] - theMean ) / theSTD );
+                datum.annotations[iii] = ( datum.isNull[iii] ? GenomeAnalysisEngine.getRandomGenerator().nextGaussian() : ( datum.annotations[iii] - theMean ) / theSTD );
                 // Each data point is now [ (x - mean) / standard deviation ]
                 if( annotationKeys.get(iii).toLowerCase().contains("ranksum") && datum.isNull[iii] && datum.annotations[iii] > 0.0 ) {
                     datum.annotations[iii] /= 3.0;

From 212e9a1a0cf766f54f70d17d0786db570f8111ae Mon Sep 17 00:00:00 2001
From: Ryan Poplin <rpoplin@broadinstitute.org>
Date: Thu, 7 Jul 2011 15:18:57 -0400
Subject: [PATCH 34/59] Fixing unstable build after stable commit

---
 .../gatk/walkers/variantrecalibration/GaussianMixtureModel.java  | 1 +
 1 file changed, 1 insertion(+)

diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/GaussianMixtureModel.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/GaussianMixtureModel.java
index b4a8c4c32..17461de2f 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/GaussianMixtureModel.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/GaussianMixtureModel.java
@@ -26,6 +26,7 @@
 package org.broadinstitute.sting.gatk.walkers.variantrecalibration;
 
 import Jama.Matrix;
+import cern.jet.random.Normal;
 import org.apache.log4j.Logger;
 import org.broadinstitute.sting.gatk.GenomeAnalysisEngine;
 import org.broadinstitute.sting.utils.MathUtils;

From 3d4f0e9dd76d1ab23a7e7fdecd61067b57b8e7d7 Mon Sep 17 00:00:00 2001
From: Mark DePristo <depristo@broadinstitute.org>
Date: Thu, 7 Jul 2011 17:21:15 -0400
Subject: [PATCH 39/59] Now supports the case where you have multiple AC values
 in the info field.

---
 .../gatk/walkers/varianteval/stratifications/AlleleCount.java | 4 ++--
 1 file changed, 2 insertions(+), 2 deletions(-)

diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/varianteval/stratifications/AlleleCount.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/varianteval/stratifications/AlleleCount.java
index ff59c9e29..2cbc66e31 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/varianteval/stratifications/AlleleCount.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/varianteval/stratifications/AlleleCount.java
@@ -43,9 +43,9 @@ public class AlleleCount extends VariantStratifier {
 
         if (eval != null) {
             int AC = -1;
-            if ( eval.hasAttribute("AC") )
+            if ( eval.hasAttribute("AC") && eval.getAttribute("AC") instanceof Integer ) {
                 AC = eval.getAttributeAsInt("AC");
-            else if ( eval.isVariant() ) {
+            } else if ( eval.isVariant() ) {
                 for (Allele allele : eval.getAlternateAlleles())
                     AC = Math.max(AC, eval.getChromosomeCount(allele));
             } else

From 4cfe0dd857891f6c70f4d0e58b60d6c4c401a0cd Mon Sep 17 00:00:00 2001
From: Eric Banks <ebanks@broadinstitute.org>
Date: Thu, 7 Jul 2011 23:01:03 -0400
Subject: [PATCH 42/59] Test for bad alleles so that we don't generate
 IndexOutOfBoundsExceptions

---
 .../sting/utils/codecs/vcf/AbstractVCFCodec.java            | 6 ++++--
 1 file changed, 4 insertions(+), 2 deletions(-)

diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/AbstractVCFCodec.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/AbstractVCFCodec.java
index cd0f52c68..01344a117 100755
--- a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/AbstractVCFCodec.java
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/AbstractVCFCodec.java
@@ -225,7 +225,7 @@ public abstract class AbstractVCFCodec implements FeatureCodec, NameAwareCodec,
             loc = pos + alleles.get(0).length() - 1;
         } else if ( !isSingleNucleotideEvent(alleles) ) {
             ArrayList<Allele> newAlleles = new ArrayList<Allele>();
-            loc = clipAlleles(pos, ref, alleles, newAlleles);
+            loc = clipAlleles(pos, ref, alleles, newAlleles, lineNo);
             alleles = newAlleles;
         }
 
@@ -504,7 +504,7 @@ public abstract class AbstractVCFCodec implements FeatureCodec, NameAwareCodec,
      * @param clippedAlleles output list of clipped alleles
      * @return a list of alleles, clipped to the reference
      */
-    protected static long clipAlleles(long position, String ref, List<Allele> unclippedAlleles, List<Allele> clippedAlleles) {
+    protected static long clipAlleles(long position, String ref, List<Allele> unclippedAlleles, List<Allele> clippedAlleles, int lineNo) {
 
         // Note that the computation of forward clipping here is meant only to see whether there is a common
         // base to all alleles, and to correctly compute reverse clipping,
@@ -522,6 +522,8 @@ public abstract class AbstractVCFCodec implements FeatureCodec, NameAwareCodec,
                 }
                 if (a.length() - reverseClipped <= forwardClipping || a.length() - forwardClipping == 0)
                     clipping = false;
+                else if (ref.length() == reverseClipped)
+                    generateException("bad alleles encountered", lineNo);
                 else if (a.getBases()[a.length()-reverseClipped-1] != ref.getBytes()[ref.length()-reverseClipped-1])
                     clipping = false;
             }

From 2a4b3ae4a20ea3d5bbd3047f2c2f7842cd01e2ef Mon Sep 17 00:00:00 2001
From: Ryan Poplin <rpoplin@broadinstitute.org>
Date: Fri, 8 Jul 2011 12:48:33 -0400
Subject: [PATCH 45/59] Cleaning up / removing most of the monkeying around
 with annotation values that happens in VariantDataManager

---
 .../VariantDataManager.java                   | 34 +++++--------------
 .../VariantRecalibrator.java                  |  6 ++--
 ...VariantRecalibratorArgumentCollection.java |  2 +-
 3 files changed, 13 insertions(+), 29 deletions(-)

diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDataManager.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDataManager.java
index 5f35c182c..ddeda1699 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDataManager.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantDataManager.java
@@ -82,19 +82,11 @@ public class VariantDataManager {
             }
 
             foundZeroVarianceAnnotation = foundZeroVarianceAnnotation || (theSTD < 1E-6);
-            if( annotationKeys.get(iii).toLowerCase().contains("ranksum") ) { // BUGBUG: to clean up
-                for( final VariantDatum datum : data ) {
-                    if( datum.annotations[iii] > 0.0 ) { datum.annotations[iii] /= 3.0; }
-                }
-            }
             meanVector[iii] = theMean;
             varianceVector[iii] = theSTD;
             for( final VariantDatum datum : data ) {
+                // Transform each data point via: (x - mean) / standard deviation
                 datum.annotations[iii] = ( datum.isNull[iii] ? GenomeAnalysisEngine.getRandomGenerator().nextGaussian() : ( datum.annotations[iii] - theMean ) / theSTD );
-                // Each data point is now [ (x - mean) / standard deviation ]
-                if( annotationKeys.get(iii).toLowerCase().contains("ranksum") && datum.isNull[iii] && datum.annotations[iii] > 0.0 ) {
-                    datum.annotations[iii] /= 3.0;
-                }
             }
         }
         if( foundZeroVarianceAnnotation ) {
@@ -163,7 +155,7 @@ public class VariantDataManager {
         final int numBadSitesAdded = trainingData.size();
         logger.info( "Found " + numBadSitesAdded + " variants overlapping bad sites training tracks." );
 
-        // Next, sort the variants by the LOD coming from the positive model and add to the list the bottom X percent of variants
+        // Next sort the variants by the LOD coming from the positive model and add to the list the bottom X percent of variants
         Collections.sort( data );
         final int numToAdd = Math.max( minimumNumber - trainingData.size(), Math.round((float)bottomPercentage * data.size()) );
         if( numToAdd > data.size() ) {
@@ -241,23 +233,15 @@ public class VariantDataManager {
         double value;
 
         try {
-            if( annotationKey.equalsIgnoreCase("QUAL") ) {
-                value = vc.getPhredScaledQual();
-            } else if( annotationKey.equalsIgnoreCase("DP") ) {
-                value = Double.parseDouble( (String)vc.getAttribute( "DP" ) ) / Double.parseDouble( (String)vc.getAttribute( "AN" ) );
-            } else {
-                value = Double.parseDouble( (String)vc.getAttribute( annotationKey ) );
-                if( Double.isInfinite(value) ) { value = Double.NaN; }
-                if( annotationKey.equalsIgnoreCase("InbreedingCoeff") && value > 0.05 ) { value = Double.NaN; }
-                if( jitter && annotationKey.equalsIgnoreCase("HRUN") ) { // Integer valued annotations must be jittered a bit to work in this GMM
-                      value += -0.25 + 0.5 * GenomeAnalysisEngine.getRandomGenerator().nextDouble();
-                }
-                if( annotationKey.equalsIgnoreCase("HaplotypeScore") && MathUtils.compareDoubles(value, 0.0, 0.0001) == 0 ) { value = -0.2 + 0.4*GenomeAnalysisEngine.getRandomGenerator().nextDouble(); }
-                if( annotationKey.equalsIgnoreCase("FS") && MathUtils.compareDoubles(value, 0.0, 0.01) == 0 ) { value = -0.2 + 0.4*GenomeAnalysisEngine.getRandomGenerator().nextDouble(); }
+            value = Double.parseDouble( (String)vc.getAttribute( annotationKey ) );
+            if( Double.isInfinite(value) ) { value = Double.NaN; }
+            if( jitter && annotationKey.equalsIgnoreCase("HRUN") ) { // Integer valued annotations must be jittered a bit to work in this GMM
+                  value += -0.25 + 0.5 * GenomeAnalysisEngine.getRandomGenerator().nextDouble();
             }
-
+            if( jitter && annotationKey.equalsIgnoreCase("HaplotypeScore") && MathUtils.compareDoubles(value, 0.0, 0.0001) == 0 ) { value = -0.2 + 0.4*GenomeAnalysisEngine.getRandomGenerator().nextDouble(); }
+            if( jitter && annotationKey.equalsIgnoreCase("FS") && MathUtils.compareDoubles(value, 0.0, 0.001) == 0 ) { value = -0.2 + 0.4*GenomeAnalysisEngine.getRandomGenerator().nextDouble(); }
         } catch( Exception e ) {
-            value = Double.NaN; // The VQSR works with missing data now by marginalizing over the missing dimension when evaluating Gaussians
+            value = Double.NaN; // The VQSR works with missing data by marginalizing over the missing dimension when evaluating the Gaussian mixture model
         }
 
         return value;
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibrator.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibrator.java
index 2c51f02d6..2d0355d7d 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibrator.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibrator.java
@@ -284,7 +284,7 @@ public class VariantRecalibrator extends RodWalker<ExpandingArrayList<VariantDat
             throw new UserException.CouldNotCreateOutputFile(RSCRIPT_FILE, "", e);
         }
 
-        // We make extensive use of the ggplot2 library: http://had.co.nz/ggplot2/
+        // We make extensive use of the ggplot2 R library: http://had.co.nz/ggplot2/
         stream.println("library(ggplot2)");
 
         createArrangeFunction( stream );
@@ -378,6 +378,7 @@ public class VariantRecalibrator extends RodWalker<ExpandingArrayList<VariantDat
         }
      }
 
+    // The Arrange function is how we place the 4 model plots on one page
     // from http://gettinggeneticsdone.blogspot.com/2010/03/arrange-multiple-ggplot2-plots-in-same.html
     private void createArrangeFunction( final PrintStream stream ) {
         stream.println("vp.layout <- function(x, y) viewport(layout.pos.row=x, layout.pos.col=y)");
@@ -402,5 +403,4 @@ public class VariantRecalibrator extends RodWalker<ExpandingArrayList<VariantDat
         stream.println("}");
         stream.println("}");
     }
-
- }
+}
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibratorArgumentCollection.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibratorArgumentCollection.java
index f597fb128..e1a815913 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibratorArgumentCollection.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/variantrecalibration/VariantRecalibratorArgumentCollection.java
@@ -60,7 +60,7 @@ public class VariantRecalibratorArgumentCollection {
     @Argument(fullName="priorCounts", shortName="priorCounts", doc="The number of prior counts to use in variational Bayes algorithm.", required=false)
     public double PRIOR_COUNTS = 20.0;
     @Argument(fullName="percentBadVariants", shortName="percentBad", doc="What percentage of the worst scoring variants to use when building the Gaussian mixture model of bad variants. 0.07 means bottom 7 percent.", required=false)
-    public double PERCENT_BAD_VARIANTS = 0.015;
+    public double PERCENT_BAD_VARIANTS = 0.03;
     @Argument(fullName="minNumBadVariants", shortName="minNumBad", doc="The minimum amount of worst scoring variants to use when building the Gaussian mixture model of bad variants. Will override -percentBad arugment if necessary.", required=false)
     public int MIN_NUM_BAD_VARIANTS = 2000;
 }

From 224574424e90152ffbe4536a4dd6061eb886f9ff Mon Sep 17 00:00:00 2001
From: Guillermo del Angel <delangel@broadinstitute.org>
Date: Fri, 8 Jul 2011 12:48:49 -0400
Subject: [PATCH 46/59] Bug fix: if we're genotyping a very long indel (>100
 bp) fail gracefully instead of with an array out of bounds exception

---
 .../org/broadinstitute/sting/utils/genotype/Haplotype.java  | 6 +++++-
 1 file changed, 5 insertions(+), 1 deletion(-)

diff --git a/public/java/src/org/broadinstitute/sting/utils/genotype/Haplotype.java b/public/java/src/org/broadinstitute/sting/utils/genotype/Haplotype.java
index cb6557408..31791e805 100755
--- a/public/java/src/org/broadinstitute/sting/utils/genotype/Haplotype.java
+++ b/public/java/src/org/broadinstitute/sting/utils/genotype/Haplotype.java
@@ -133,8 +133,12 @@ public class Haplotype {
 
 
         byte[] basesBeforeVariant = Arrays.copyOfRange(refBases,startIdxInReference,startIdxInReference+numPrefBases);
+        int startAfter = startIdxInReference+numPrefBases+ refAllele.getBases().length;
+        // protect against long events that overrun available reference context
+        if (startAfter > refBases.length)
+            startAfter = refBases.length;
         byte[] basesAfterVariant = Arrays.copyOfRange(refBases,
-                startIdxInReference+numPrefBases+ refAllele.getBases().length, refBases.length);
+                startAfter, refBases.length);
 
 
         // Create location for all haplotypes

From a3c9d9c3ff561a0a910b5313e0ebb037b7883a4b Mon Sep 17 00:00:00 2001
From: David Roazen <droazen@broadinstitute.org>
Date: Fri, 8 Jul 2011 15:34:39 -0400
Subject: [PATCH 51/59] Fixing Contracts for Java, and enabling contracts by
 default for unit/integration tests.

The NullPointerException we were seeing when trying to run with contracts enabled was being caused
by an outdated version of the asm library.

To run tests without contracts and disable their compilation, pass in "-Duse.contracts=false" to ant.

Also did some minor unrelated cleanup in build.xml
---
 build.xml                                     |  70 +++++++++++-------
 ivy.xml                                       |   4 +
 settings/ivysettings.xml                      |   1 +
 .../cofoja-1.0-20110609.jar                   | Bin
 .../cofoja-1.0-20110609.xml                   |   3 +
 5 files changed, 51 insertions(+), 27 deletions(-)
 rename settings/repository/{com.google => com.google.code.cofoja}/cofoja-1.0-20110609.jar (100%)
 create mode 100644 settings/repository/com.google.code.cofoja/cofoja-1.0-20110609.xml

diff --git a/build.xml b/build.xml
index 2a23f74c1..986d89213 100644
--- a/build.xml
+++ b/build.xml
@@ -28,6 +28,7 @@
 
     <property name="build.dir" value="build" />
     <property name="dist.dir" value="dist" />
+    <property name="lib.dir" value="lib" />
     <property name="external.dir" value="external" />
     <property name="public.dir" value="public" />
     <property name="private.dir" value="private" />
@@ -44,11 +45,11 @@
     <property name="queue-extensions.source.dir" value="${build.dir}/queue-extensions/src" />
     
     <!-- Contracts for Java -->
-    <!-- uncomment out to enable building contracts -->
-    <property name="use.contracts" value="true" /> 
+    <!-- To disable, run with -Duse.contracts=false -->
+    <property name="use.contracts" value="true" />
     <property name="java.contracts" value="${build.dir}/java/contracts" />
-    <property name="cofojaDir" value="settings/repository/com.google/"/>
-    <property name="cofoja.jar" value="${cofojaDir}/cofoja-1.0-20110609.jar"/>
+    <property name="contracts.version" value="1.0-20110609" />
+    <property name="cofoja.jar" value="${lib.dir}/cofoja-${contracts.version}.jar"/>
     
     <!-- where to find the tribble distro -->
     <property name="tribble.dir" value="tribble" />
@@ -69,7 +70,7 @@
 
     <property environment="env"/>
 
-    <property name="drmaa.jar" value="${env.SGE_ROOT}/lib/drmaa.jar" />
+    <property name="drmaa.jar" value="${env.SGE_ROOT}/${lib.dir}/drmaa.jar" />
 
     <patternset id="java.source.pattern">
         <include name="${java.public.source.dir}/**/*.java" />
@@ -103,7 +104,7 @@
     </patternset>
     
     <path id="external.dependencies">
-      <fileset dir="lib">
+      <fileset dir="${lib.dir}">
         <patternset refid="dependency.mask" />
       </fileset>
     </path>
@@ -128,14 +129,14 @@
         <!-- ivy properties -->
         <property name="ivy.install.version" value="2.2.0"/>
         <property name="ivy.home" value="${user.home}/.ant"/>
-        <property name="ivy.jar.dir" value="${ivy.home}/lib"/>
+        <property name="ivy.jar.dir" value="${ivy.home}/${lib.dir}"/>
         <property name="ivy.jar.file" value="ivy-${ivy.install.version}.jar"/>
         <property name="ivy.settings.dir" value="settings"/>
         <property file="${ivy.settings.dir}/ivysettings.properties"/>
   
-      <mkdir dir="lib"/>
+      <mkdir dir="${lib.dir}"/>
       <mkdir dir="${ivy.jar.dir}"/>
-      <copy file="${cofoja.jar}" toFile="lib/cofoja.jar"/>
+
       <get src="http://repo1.maven.org/maven2/org/apache/ivy/ivy/${ivy.install.version}/${ivy.jar.file}"
            dest="${ivy.jar.dir}/${ivy.jar.file}"
            usetimestamp="true"/>
@@ -147,7 +148,7 @@
     </target>
 
     <target name="init.gridengine" depends="init" if="include.gridengine">
-        <copy todir="lib" file="${drmaa.jar}"/>
+        <copy todir="${lib.dir}" file="${drmaa.jar}"/>
     </target>
 
     <target name="resolve" depends="init.resolve,init,init.gridengine"
@@ -229,6 +230,10 @@
         <equals arg1="${gatk.target}" arg2="private" casesensitive="false" />
       </condition>
 
+      <condition property="include.contracts">
+        <equals arg1="${use.contracts}" arg2="true" />
+      </condition>
+
       <!-- Create the build directory structure used by compile -->
       <mkdir dir="${build.dir}"/>
       <mkdir dir="${java.classes}"/>
@@ -252,7 +257,7 @@
     <target name="init.scala.compile" depends="resolve"
             description="Initializes the scala ant tasks from scala-compiler.jar">
         <path id="scala.classpath">
-            <fileset dir="lib">
+            <fileset dir="${lib.dir}">
                 <include name="scala-compiler-*.jar"/>
                 <include name="scala-library-*.jar"/>
             </fileset>
@@ -287,7 +292,7 @@
             depends="gatk.compile.public.source,gatk.compile.private.source,gatk.compile.external.source" 
             description="compile the GATK source" />
 
-   <target name="gatk.contracts.public" depends="gatk.compile.source">
+   <target name="gatk.contracts.public" depends="gatk.compile.source" if="include.contracts">
         <javac fork="true" memoryMaximumSize="512m" srcdir="${java.public.source.dir}" destdir="${java.contracts}" debug="true" debuglevel="lines,vars,source" tempdir="${java.io.tmpdir}" >
             <classpath>
                 <path refid="external.dependencies" />
@@ -299,7 +304,16 @@
         </javac>   
    </target>
 
-   <target name="gatk.contracts.private" depends="gatk.compile.source" if="include.private">
+    <target name="check.contracts.private" depends="gatk.contracts.public">
+        <condition property="include.contracts.private">
+          <and>
+            <isset property="include.contracts" />
+            <isset property="include.private" />
+          </and>
+        </condition>
+    </target>
+
+   <target name="gatk.contracts.private" depends="check.contracts.private" if="include.contracts.private">
         <javac fork="true" memoryMaximumSize="512m" srcdir="${java.private.source.dir}" destdir="${java.contracts}" debug="true" debuglevel="lines,vars,source" tempdir="${java.io.tmpdir}" >
             <classpath>
                 <path refid="external.dependencies" />
@@ -312,7 +326,7 @@
    </target>
 
     <target name="gatk.contracts" depends="gatk.contracts.public,gatk.contracts.private" 
-            description="create GATK contracts" if="use.contracts" />
+            description="create GATK contracts" if="include.contracts" />
     
     <target name="gatk.compile" depends="tribble,init,resolve,gatk.compile.source,gatk.contracts" />
 
@@ -452,7 +466,7 @@
     <target name="init.jar" depends="sting.compile,extracthelp">
         <mkdir dir="${dist.dir}"/>
         <copy todir="${dist.dir}">
-            <fileset dir="lib" includes="*.jar"/>
+            <fileset dir="${lib.dir}" includes="*.jar"/>
         </copy>
     </target>
 
@@ -663,7 +677,7 @@
                 <path refid="external.dependencies" />
                 <pathelement location="${java.classes}"/>
                 <pathelement location="${java.contracts}"/>
-                <pathelement location="lib/testng-5.14.1.jar"/>
+                <pathelement location="${lib.dir}/testng-5.14.1.jar"/>
             </classpath>
             <compilerarg value="-proc:none"/>
 <!-- 
@@ -687,7 +701,7 @@
                 <path refid="scala.dependencies"/>
                 <pathelement location="${scala.test.classes}"/>
                 <pathelement location="${java.test.classes}"/>
-                <pathelement location="lib/testng-5.14.1.jar"/>
+                <pathelement location="${lib.dir}/testng-5.14.1.jar"/>
             </classpath>
         </scalac>
     </target>
@@ -727,9 +741,13 @@
                 <equals arg1="${pipeline.run}" arg2="$${pipeline.run}" />
             </condition>
 
+            <condition property="cofoja.jvm.args" value="-javaagent:${cofoja.jar} -Dcom.google.java.contract.log.contract=false" else="">
+                <isset property="include.contracts" />
+            </condition>
+
             <mkdir dir="${report}/@{testtype}"/>
             <echo message="Sting: Running @{testtype} test cases!"/>
-            <taskdef resource="testngtasks" classpath="lib/testng-5.14.1.jar"/>
+            <taskdef resource="testngtasks" classpath="${lib.dir}/testng-5.14.1.jar"/>
             <testng outputDir="${report}/@{testtype}"
                     haltOnFailure="false" failureProperty="test.failure"
                     verbose="2"
@@ -740,9 +758,7 @@
                 <jvmarg value="-Djava.awt.headless=true" />
                 <jvmarg value="-Dpipeline.run=${pipeline.run}" />
                 <jvmarg value="-Djava.io.tmpdir=${java.io.tmpdir}" />
-                <!-- needs to be if -->
-                <!--jvmarg value="-javaagent:lib/cofoja.jar"/-->
-                <!--jvmarg value="-Dcom.google.java.contract.log.contract=false"/-->
+                <jvmarg line="${cofoja.jvm.args}"/>
 <!--                 <jvmarg value="-Xdebug"/> -->
 <!--                 <jvmarg value="-Xrunjdwp:transport=dt_socket,server=y,suspend=y,address=5005"/> -->
                 <classpath>
@@ -820,7 +836,7 @@
 
     <!-- copy the compiled library -->
     <target name="tribble.compile.copy" description="Copies the compiled tribble library" depends="tribble.compile" if="tribble.compile.exists">
-        <copy todir="lib">
+        <copy todir="${lib.dir}">
             <fileset dir="${tribble.dir}/dist" includes="*.jar"/>
         </copy>
     </target>
@@ -828,7 +844,7 @@
     <!-- copy the precompiled library -->
     <target name="tribble.library.copy" description="Copies the precompiled tribble library" depends="tribble.init" unless="tribble.compile.exists">
         <echo message="Copying the Tribble Library..."/>
-        <copy todir="lib">
+        <copy todir="${lib.dir}">
             <fileset dir="settings/repository/org.broad" includes="tribble*.jar"/>
         </copy>
     </target>
@@ -921,8 +937,8 @@
       <pathconvert property="required.picard.jars" pathsep=":">
         <fileset dir="${basedir}">
 	     <include name="staging" />
-	     <include name="lib/picard-*.*.*.jar" />
-	     <include name="lib/sam-*.jar" />
+	     <include name="${lib.dir}/picard-*.*.*.jar" />
+	     <include name="${lib.dir}/sam-*.jar" />
 	   </fileset>
       </pathconvert>
       <echo message="required.picard.jars=${required.picard.jars}" />
@@ -944,7 +960,7 @@
     <!-- Find bug tasks                                                                   -->
     <!-- ******************************************************************************** -->
     <path id="findbugs.classpath">
-      <fileset dir="lib" erroronmissingdir="true" includes="*.jar"/>
+      <fileset dir="${lib.dir}" erroronmissingdir="true" includes="*.jar"/>
     </path>
     <target         name="findbugs" depends="dist">
         <antcall    target  ="resolve">
@@ -969,7 +985,7 @@
     <target name="clean" description="clean up" depends="tribble.clean,clean.javadoc">
         <delete dir="out"/>
         <delete dir="${build.dir}"/>
-        <delete dir="lib"/>
+        <delete dir="${lib.dir}"/>
         <delete dir="staging"/>
         <delete dir="${dist.dir}"/>
         <delete dir="pipelinetests"/>
diff --git a/ivy.xml b/ivy.xml
index c2a6c4ccd..ce724bc3c 100644
--- a/ivy.xml
+++ b/ivy.xml
@@ -60,6 +60,10 @@
     <dependency org="net.sourceforge.findbugs" name="jsr305" rev="1.3.2" conf="test"/>
     <dependency org="com.google.code.caliper" name="caliper" rev="1.0-SNAPSHOT" conf="test" />
 
+    <!-- Contracts for Java and dependencies -->
+    <dependency org="com.google.code.cofoja" name="cofoja" rev="1.0-20110609" />
+    <dependency org="asm" name="asm-all" rev="3.3.1" />
+
     <!-- POI, for reading pipeline files -->
     <dependency org="org.apache.poi" name="poi" rev="3.8-beta3" />
     <dependency org="org.apache.poi" name="poi-ooxml" rev="3.8-beta3" />
diff --git a/settings/ivysettings.xml b/settings/ivysettings.xml
index 1e47fa847..b77414df9 100644
--- a/settings/ivysettings.xml
+++ b/settings/ivysettings.xml
@@ -25,5 +25,6 @@
     <module organisation="javax.activation" resolver="java.net" />
     <module organisation="net.java.dev.jna" resolver="maven2-repository.dev.java.net" />
     <module organisation="com.google.code.caliper" resolver="projects" />
+    <module organisation="com.google.code.cofoja" resolver="projects" />
   </modules>
 </ivysettings>
diff --git a/settings/repository/com.google/cofoja-1.0-20110609.jar b/settings/repository/com.google.code.cofoja/cofoja-1.0-20110609.jar
similarity index 100%
rename from settings/repository/com.google/cofoja-1.0-20110609.jar
rename to settings/repository/com.google.code.cofoja/cofoja-1.0-20110609.jar
diff --git a/settings/repository/com.google.code.cofoja/cofoja-1.0-20110609.xml b/settings/repository/com.google.code.cofoja/cofoja-1.0-20110609.xml
new file mode 100644
index 000000000..38d4e88f1
--- /dev/null
+++ b/settings/repository/com.google.code.cofoja/cofoja-1.0-20110609.xml
@@ -0,0 +1,3 @@
+<ivy-module version="1.0">
+    <info organisation="com.google.code.cofoja" module="cofoja" revision="1.0-20110609" status="integration" publication="20110609114800" />
+</ivy-module>

From 8a78414432226daceccccb4b38463c0826fb0f19 Mon Sep 17 00:00:00 2001
From: David Roazen <droazen@broadinstitute.org>
Date: Mon, 11 Jul 2011 12:10:11 -0400
Subject: [PATCH 52/59] Removed TileCovariate as a dependency for
 AnalyzeCovariates.jar

---
 public/packages/AnalyzeCovariates.xml | 1 -
 1 file changed, 1 deletion(-)

diff --git a/public/packages/AnalyzeCovariates.xml b/public/packages/AnalyzeCovariates.xml
index 1862d6cbb..7e31934df 100644
--- a/public/packages/AnalyzeCovariates.xml
+++ b/public/packages/AnalyzeCovariates.xml
@@ -10,7 +10,6 @@
       <class name="org.broadinstitute.sting.gatk.walkers.recalibration.QualityScoreCovariate" />
       <class name="org.broadinstitute.sting.gatk.walkers.recalibration.CycleCovariate" />
       <class name="org.broadinstitute.sting.gatk.walkers.recalibration.ReadGroupCovariate" />
-      <class name="org.broadinstitute.sting.gatk.walkers.recalibration.TileCovariate" />
     </dependencies>
   </executable>
   <resources>

From 86890c63574eba41bbbce6c52e2614f6c81b6f27 Mon Sep 17 00:00:00 2001
From: Christopher Hartl <chartl@broadinstitute.org>
Date: Mon, 11 Jul 2011 16:16:15 -0400
Subject: [PATCH 54/59] N and K (in binomial probability) got switched in RFA
 Walker with the last commit. No longer will NaNs be produced.

Added: TableToVCF. Kind of a longer-term project, but there are lots of variant calls available in a weird tabular format. I used this to convert Ju Et Al small indels to VCF. I'll check against the 1000G ASN superpopulation calls to see if we see a good amount of recapitulation, and if so, i'll put them in unvalidated comparisons. Minor chances to the TableCodec and TableFeatures to allow for this (the codec can sometimes drop a column, and the feature now allows you to grab on to its header).
---
 .../sting/gatk/refdata/features/table/TableCodec.java       | 0
 .../sting/gatk/refdata/features/table/TableFeature.java     | 6 +++++-
 .../broadinstitute/sting/utils/variantcontext/Allele.java   | 2 +-
 3 files changed, 6 insertions(+), 2 deletions(-)
 mode change 100644 => 100755 public/java/src/org/broadinstitute/sting/gatk/refdata/features/table/TableCodec.java
 mode change 100644 => 100755 public/java/src/org/broadinstitute/sting/gatk/refdata/features/table/TableFeature.java

diff --git a/public/java/src/org/broadinstitute/sting/gatk/refdata/features/table/TableCodec.java b/public/java/src/org/broadinstitute/sting/gatk/refdata/features/table/TableCodec.java
old mode 100644
new mode 100755
diff --git a/public/java/src/org/broadinstitute/sting/gatk/refdata/features/table/TableFeature.java b/public/java/src/org/broadinstitute/sting/gatk/refdata/features/table/TableFeature.java
old mode 100644
new mode 100755
index 6ff0384a0..4b4ebe450
--- a/public/java/src/org/broadinstitute/sting/gatk/refdata/features/table/TableFeature.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/refdata/features/table/TableFeature.java
@@ -55,10 +55,14 @@ public class TableFeature implements Feature {
     }
 
     public List<String> getAllValues() {
-        return getValuesTo(values.size()-1);
+        return getValuesTo(values.size());
     }
 
     public List<String> getValuesTo(int columnPosition) {
         return values.subList(0,columnPosition);
     }
+
+    public List<String> getHeader() {
+        return keys;
+    }
 }
diff --git a/public/java/src/org/broadinstitute/sting/utils/variantcontext/Allele.java b/public/java/src/org/broadinstitute/sting/utils/variantcontext/Allele.java
index a9ba46159..901de6fae 100755
--- a/public/java/src/org/broadinstitute/sting/utils/variantcontext/Allele.java
+++ b/public/java/src/org/broadinstitute/sting/utils/variantcontext/Allele.java
@@ -108,7 +108,7 @@ public class Allele implements Comparable<Allele> {
         this.bases = bases;
 
         if ( ! acceptableAlleleBases(bases) )
-            throw new IllegalArgumentException("Unexpected base in allele bases " + new String(bases));
+            throw new IllegalArgumentException("Unexpected base in allele bases \'" + new String(bases)+"\'");
     }
 
     private Allele(String bases, boolean isRef) {

From e3748675dbd518042ad67cfc653c7f1a5f89b327 Mon Sep 17 00:00:00 2001
From: Eric Banks <ebanks@broadinstitute.org>
Date: Mon, 11 Jul 2011 17:40:45 -0400
Subject: [PATCH 55/59] Support for VCF 4.1 header counts

---
 .../annotator/DepthPerAlleleBySample.java     |  3 +-
 .../ReadDepthAndAllelicFractionBySample.java  |  5 +-
 .../gatk/walkers/annotator/SampleList.java    |  3 +-
 .../utils/codecs/vcf/StandardVCFWriter.java   | 11 +--
 .../codecs/vcf/VCFCompoundHeaderLine.java     | 91 +++++++++++++++----
 .../sting/utils/codecs/vcf/VCFConstants.java  |  2 +
 .../utils/codecs/vcf/VCFFormatHeaderLine.java |  4 +
 .../utils/codecs/vcf/VCFHeaderLineCount.java  |  8 ++
 .../utils/codecs/vcf/VCFInfoHeaderLine.java   |  4 +
 9 files changed, 101 insertions(+), 30 deletions(-)
 create mode 100644 public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFHeaderLineCount.java

diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/DepthPerAlleleBySample.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/DepthPerAlleleBySample.java
index 754d28dfd..ee66b50ee 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/DepthPerAlleleBySample.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/DepthPerAlleleBySample.java
@@ -1,5 +1,6 @@
 package org.broadinstitute.sting.gatk.walkers.annotator;
 
+import org.broadinstitute.sting.utils.codecs.vcf.VCFHeaderLineCount;
 import org.broadinstitute.sting.utils.variantcontext.Allele;
 import org.broadinstitute.sting.utils.variantcontext.Genotype;
 import org.broadinstitute.sting.utils.variantcontext.VariantContext;
@@ -142,5 +143,5 @@ public class DepthPerAlleleBySample implements GenotypeAnnotation, StandardAnnot
  //   public String getIndelBases()
     public List<String> getKeyNames() { return Arrays.asList("AD"); }
 
-    public List<VCFFormatHeaderLine> getDescriptions() { return Arrays.asList(new VCFFormatHeaderLine(getKeyNames().get(0), VCFCompoundHeaderLine.UNBOUNDED, VCFHeaderLineType.Integer, "Allelic depths for the ref and alt alleles in the order listed")); }
+    public List<VCFFormatHeaderLine> getDescriptions() { return Arrays.asList(new VCFFormatHeaderLine(getKeyNames().get(0), VCFHeaderLineCount.UNBOUNDED, VCFHeaderLineType.Integer, "Allelic depths for the ref and alt alleles in the order listed")); }
 }
\ No newline at end of file
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/ReadDepthAndAllelicFractionBySample.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/ReadDepthAndAllelicFractionBySample.java
index f287549bb..a670532af 100644
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/ReadDepthAndAllelicFractionBySample.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/ReadDepthAndAllelicFractionBySample.java
@@ -29,6 +29,7 @@ import org.broadinstitute.sting.gatk.contexts.AlignmentContext;
 import org.broadinstitute.sting.gatk.walkers.annotator.interfaces.GenotypeAnnotation;
 import org.broadinstitute.sting.gatk.refdata.RefMetaDataTracker;
 import org.broadinstitute.sting.gatk.contexts.ReferenceContext;
+import org.broadinstitute.sting.utils.codecs.vcf.VCFHeaderLineCount;
 import org.broadinstitute.sting.utils.pileup.ReadBackedPileup;
 import org.broadinstitute.sting.utils.pileup.PileupElement;
 import org.broadinstitute.sting.utils.pileup.ReadBackedExtendedEventPileup;
@@ -200,8 +201,8 @@ public class ReadDepthAndAllelicFractionBySample implements GenotypeAnnotation {
                             1,
                             VCFHeaderLineType.Integer,
                             "Total read depth per sample, including MQ0"),
-                    new VCFFormatHeaderLine(getKeyNames().get(1),
-                            VCFCompoundHeaderLine.UNBOUNDED,
+                            new VCFFormatHeaderLine(getKeyNames().get(1),
+                            VCFHeaderLineCount.UNBOUNDED,
                             VCFHeaderLineType.Float,
                             "Fractions of reads (excluding MQ0 from both ref and alt) supporting each reported alternative allele, per sample"));
         }
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/SampleList.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/SampleList.java
index 82f16be42..e2fd2a3d4 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/SampleList.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/SampleList.java
@@ -25,6 +25,7 @@
 
 package org.broadinstitute.sting.gatk.walkers.annotator;
 
+import org.broadinstitute.sting.utils.codecs.vcf.VCFHeaderLineCount;
 import org.broadinstitute.sting.utils.variantcontext.Genotype;
 import org.broadinstitute.sting.utils.variantcontext.VariantContext;
 import org.broadinstitute.sting.utils.codecs.vcf.VCFHeaderLineType;
@@ -65,5 +66,5 @@ public class SampleList implements InfoFieldAnnotation {
 
     public List<String> getKeyNames() { return Arrays.asList("Samples"); }
 
-    public List<VCFInfoHeaderLine> getDescriptions() { return Arrays.asList(new VCFInfoHeaderLine("Samples", VCFInfoHeaderLine.UNBOUNDED, VCFHeaderLineType.String, "List of polymorphic samples")); }
+    public List<VCFInfoHeaderLine> getDescriptions() { return Arrays.asList(new VCFInfoHeaderLine("Samples", VCFHeaderLineCount.UNBOUNDED, VCFHeaderLineType.String, "List of polymorphic samples")); }
 }
diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/StandardVCFWriter.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/StandardVCFWriter.java
index 31251c089..230773310 100755
--- a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/StandardVCFWriter.java
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/StandardVCFWriter.java
@@ -360,14 +360,7 @@ public class StandardVCFWriter implements VCFWriter {
             if ( !entry.getValue().equals("") ) {
                 int numVals = 1;
                 VCFInfoHeaderLine metaData = mHeader.getInfoHeaderLine(key);
-                if ( metaData != null )
-                    numVals = metaData.getCount();
-
-                // take care of unbounded encoding
-                if ( numVals == VCFInfoHeaderLine.UNBOUNDED )
-                    numVals = 1;
-
-                if ( numVals > 0 ) {
+                if ( metaData != null && (metaData.getCountType() != VCFHeaderLineCount.INTEGER || metaData.getCount() > 0) ) {
                     mWriter.write("=");
                     mWriter.write(entry.getValue());
                 }
@@ -423,7 +416,7 @@ public class StandardVCFWriter implements VCFWriter {
 
                 VCFFormatHeaderLine metaData = mHeader.getFormatHeaderLine(key);
                 if ( metaData != null ) {
-                    int numInFormatField = metaData.getCount();
+                    int numInFormatField = metaData.getCount(vc.getAlternateAlleles().size());
                     if ( numInFormatField > 1 && val.equals(VCFConstants.MISSING_VALUE_v4) ) {
                         // If we have a missing field but multiple values are expected, we need to construct a new string with all fields.
                         // For example, if Number=2, the string has to be ".,."
diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFCompoundHeaderLine.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFCompoundHeaderLine.java
index a799161ad..49f9ab184 100755
--- a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFCompoundHeaderLine.java
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFCompoundHeaderLine.java
@@ -24,6 +24,8 @@
 
 package org.broadinstitute.sting.utils.codecs.vcf;
 
+import org.broadinstitute.sting.utils.exceptions.ReviewedStingException;
+
 import java.util.Arrays;
 import java.util.LinkedHashMap;
 import java.util.Map;
@@ -43,26 +45,43 @@ public abstract class VCFCompoundHeaderLine extends VCFHeaderLine implements VCF
 
     // the field types
     private String name;
-    private int count;
+    private int count = -1;
+    private VCFHeaderLineCount countType;
     private String description;
     private VCFHeaderLineType type;
 
     // access methods
     public String getName() { return name; }
-    public int getCount() { return count; }
     public String getDescription() { return description; }
     public VCFHeaderLineType getType() { return type; }
+    public VCFHeaderLineCount getCountType() { return countType; }
+    public int getCount() {
+        if ( countType != VCFHeaderLineCount.INTEGER )
+            throw new ReviewedStingException("Asking for header line count when type is not an integer");
+        return count;
+    }
 
-    //
-    public void setNumberToUnbounded() { this.count = UNBOUNDED; }
+    // utility method
+    public int getCount(int numAltAlleles) {
+        int myCount;
+        switch ( countType ) {
+            case INTEGER: myCount = count; break;
+            case UNBOUNDED: myCount = -1; break;
+            case A: myCount = numAltAlleles; break;
+            case G: myCount = ((numAltAlleles + 1) * (numAltAlleles + 2) / 2); break;
+            default: throw new ReviewedStingException("Unknown count type: " + countType);
+        }
+        return myCount;
+    }
+
+    public void setNumberToUnbounded() {
+        countType = VCFHeaderLineCount.UNBOUNDED;
+        count = -1;
+    }
 
     // our type of line, i.e. format, info, etc
     private final SupportedHeaderLineType lineType;
 
-    // line numerical values are allowed to be unbounded (or unknown), which is
-    // marked with a dot (.)
-    public static final int UNBOUNDED = -1;    // the value we store internally for unbounded types
-
     /**
      * create a VCF format header line
      *
@@ -74,6 +93,7 @@ public abstract class VCFCompoundHeaderLine extends VCFHeaderLine implements VCF
     protected VCFCompoundHeaderLine(String name, int count, VCFHeaderLineType type, String description, SupportedHeaderLineType lineType) {
         super(lineType.toString(), "");
         this.name = name;
+        this.countType = VCFHeaderLineCount.INTEGER;
         this.count = count;
         this.type = type;
         this.description = description;
@@ -81,6 +101,24 @@ public abstract class VCFCompoundHeaderLine extends VCFHeaderLine implements VCF
         validate();
     }
 
+    /**
+     * create a VCF format header line
+     *
+     * @param name         the name for this header line
+     * @param count        the count type for this header line
+     * @param type         the type for this header line
+     * @param description  the description for this header line
+     */
+    protected VCFCompoundHeaderLine(String name, VCFHeaderLineCount count, VCFHeaderLineType type, String description, SupportedHeaderLineType lineType) {
+        super(lineType.toString(), "");
+        this.name = name;
+        this.countType = count;
+        this.type = type;
+        this.description = description;
+        this.lineType = lineType;
+        validate();
+    }
+
     /**
      * create a VCF format header line
      *
@@ -92,9 +130,22 @@ public abstract class VCFCompoundHeaderLine extends VCFHeaderLine implements VCF
         super(lineType.toString(), "");
         Map<String,String> mapping = VCFHeaderLineTranslator.parseLine(version,line, Arrays.asList("ID","Number","Type","Description"));
         name = mapping.get("ID");
-        count = (version == VCFHeaderVersion.VCF4_0 || version == VCFHeaderVersion.VCF4_1) ?
-                        mapping.get("Number").equals(VCFConstants.UNBOUNDED_ENCODING_v4) ? UNBOUNDED : Integer.valueOf(mapping.get("Number")) :
-                        mapping.get("Number").equals(VCFConstants.UNBOUNDED_ENCODING_v3) ? UNBOUNDED : Integer.valueOf(mapping.get("Number"));
+        count = -1;
+        final String numberStr = mapping.get("Number");
+        if ( numberStr.equals(VCFConstants.PER_ALLELE_COUNT) ) {
+            countType = VCFHeaderLineCount.A;
+        } else if ( numberStr.equals(VCFConstants.PER_GENOTYPE_COUNT) ) {
+            countType = VCFHeaderLineCount.G;
+        } else if ( ((version == VCFHeaderVersion.VCF4_0 || version == VCFHeaderVersion.VCF4_1) &&
+                     numberStr.equals(VCFConstants.UNBOUNDED_ENCODING_v4)) ||
+                    ((version == VCFHeaderVersion.VCF3_2 || version == VCFHeaderVersion.VCF3_3) &&
+                     numberStr.equals(VCFConstants.UNBOUNDED_ENCODING_v3)) ) {
+            countType = VCFHeaderLineCount.UNBOUNDED;
+        } else {
+            countType = VCFHeaderLineCount.INTEGER;
+            count = Integer.valueOf(numberStr);
+
+        }
         type = VCFHeaderLineType.valueOf(mapping.get("Type"));
         if (type == VCFHeaderLineType.Flag && !allowFlagValues())
             throw new IllegalArgumentException("Flag is an unsupported type for this kind of field");
@@ -121,7 +172,15 @@ public abstract class VCFCompoundHeaderLine extends VCFHeaderLine implements VCF
     protected String toStringEncoding() {
         Map<String,Object> map = new LinkedHashMap<String,Object>();
         map.put("ID", name);
-        map.put("Number", count == UNBOUNDED ? VCFConstants.UNBOUNDED_ENCODING_v4 : count);
+        Object number;
+        switch ( countType ) {
+            case A: number = VCFConstants.PER_ALLELE_COUNT; break;
+            case G: number = VCFConstants.PER_GENOTYPE_COUNT; break;
+            case UNBOUNDED: number = VCFConstants.UNBOUNDED_ENCODING_v4; break;
+            case INTEGER:
+            default: number = count;
+        }
+        map.put("Number", number);
         map.put("Type", type);
         map.put("Description", description);
         return lineType.toString() + "=" + VCFHeaderLine.toStringEncoding(map);
@@ -136,15 +195,13 @@ public abstract class VCFCompoundHeaderLine extends VCFHeaderLine implements VCF
         if ( !(o instanceof VCFCompoundHeaderLine) )
             return false;
         VCFCompoundHeaderLine other = (VCFCompoundHeaderLine)o;
-        return name.equals(other.name) &&
-                count == other.count &&
-                description.equals(other.description) &&
-                type == other.type &&
-                lineType == other.lineType;
+        return equalsExcludingDescription(other) &&
+                description.equals(other.description);
     }
 
     public boolean equalsExcludingDescription(VCFCompoundHeaderLine other) {
         return count == other.count &&
+                countType == other.countType &&
                 type == other.type &&
                 lineType == other.lineType &&
                 name.equals(other.name);
diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFConstants.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFConstants.java
index 695c46c27..91cf86c70 100755
--- a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFConstants.java
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFConstants.java
@@ -99,6 +99,8 @@ public final class VCFConstants {
     public static final String MISSING_DEPTH_v3 = "-1";
     public static final String UNBOUNDED_ENCODING_v4 = ".";
     public static final String UNBOUNDED_ENCODING_v3 = "-1";
+    public static final String PER_ALLELE_COUNT = "A";
+    public static final String PER_GENOTYPE_COUNT = "G";
     public static final String EMPTY_ALLELE = ".";
     public static final String EMPTY_GENOTYPE = "./.";
     public static final double MAX_GENOTYPE_QUAL = 99.0;
diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFFormatHeaderLine.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFFormatHeaderLine.java
index 352be3e97..f68cb670b 100755
--- a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFFormatHeaderLine.java
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFFormatHeaderLine.java
@@ -16,6 +16,10 @@ public class VCFFormatHeaderLine extends VCFCompoundHeaderLine {
             throw new IllegalArgumentException("Flag is an unsupported type for format fields");
     }
 
+    public VCFFormatHeaderLine(String name, VCFHeaderLineCount count, VCFHeaderLineType type, String description) {
+        super(name, count, type, description, SupportedHeaderLineType.INFO);
+    }
+
     protected VCFFormatHeaderLine(String line, VCFHeaderVersion version) {
         super(line, version, SupportedHeaderLineType.FORMAT);
     }
diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFHeaderLineCount.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFHeaderLineCount.java
new file mode 100644
index 000000000..d615c7c78
--- /dev/null
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFHeaderLineCount.java
@@ -0,0 +1,8 @@
+package org.broadinstitute.sting.utils.codecs.vcf;
+
+/**
+ * the count encodings we use for fields in VCF header lines
+ */
+public enum VCFHeaderLineCount {
+    INTEGER, A, G, UNBOUNDED;
+}
diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFInfoHeaderLine.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFInfoHeaderLine.java
index 135a5c1a1..9b20f38a1 100755
--- a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFInfoHeaderLine.java
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFInfoHeaderLine.java
@@ -13,6 +13,10 @@ public class VCFInfoHeaderLine extends VCFCompoundHeaderLine {
         super(name, count, type, description, SupportedHeaderLineType.INFO);
     }
 
+    public VCFInfoHeaderLine(String name, VCFHeaderLineCount count, VCFHeaderLineType type, String description) {
+        super(name, count, type, description, SupportedHeaderLineType.INFO);
+    }
+
     protected VCFInfoHeaderLine(String line, VCFHeaderVersion version) {
         super(line, version, SupportedHeaderLineType.INFO);
     }

From e93052a51e88ddb77c8ce71cf6a14a449ca3b1aa Mon Sep 17 00:00:00 2001
From: Khalid Shakir <kshakir@broadinstitute.org>
Date: Mon, 11 Jul 2011 19:17:58 -0400
Subject: [PATCH 56/59] When generating the QGraph, don't regenerate if there
 aren't scatter/gather jobs. Fixed a display issue with the number of
 milliseconds that Queue has tried to contact LSF.

---
 .../sting/queue/engine/QGraph.scala           | 44 ++++++++++---------
 .../queue/engine/lsf/Lsf706JobRunner.scala    |  6 +--
 2 files changed, 26 insertions(+), 24 deletions(-)

diff --git a/public/scala/src/org/broadinstitute/sting/queue/engine/QGraph.scala b/public/scala/src/org/broadinstitute/sting/queue/engine/QGraph.scala
index bfcc4d48c..8ed3f84c1 100755
--- a/public/scala/src/org/broadinstitute/sting/queue/engine/QGraph.scala
+++ b/public/scala/src/org/broadinstitute/sting/queue/engine/QGraph.scala
@@ -138,30 +138,32 @@ class QGraph extends Logging {
     validate()
 
     if (running && numMissingValues == 0) {
-      logger.info("Generating scatter gather jobs.")
       val scatterGathers = jobGraph.edgeSet.filter(edge => scatterGatherable(edge))
+      if (!scatterGathers.isEmpty) {
+        logger.info("Generating scatter gather jobs.")
 
-      var addedFunctions = List.empty[QFunction]
-      for (scatterGather <- scatterGathers) {
-        val functions = scatterGather.asInstanceOf[FunctionEdge]
-                .function.asInstanceOf[ScatterGatherableFunction]
-                .generateFunctions()
-        addedFunctions ++= functions
+        var addedFunctions = List.empty[QFunction]
+        for (scatterGather <- scatterGathers) {
+          val functions = scatterGather.asInstanceOf[FunctionEdge]
+                  .function.asInstanceOf[ScatterGatherableFunction]
+                  .generateFunctions()
+          addedFunctions ++= functions
+        }
+
+        logger.info("Removing original jobs.")
+        this.jobGraph.removeAllEdges(scatterGathers)
+        prune()
+
+        logger.info("Adding scatter gather jobs.")
+        addedFunctions.foreach(function => if (running) this.add(function))
+
+        logger.info("Regenerating graph.")
+        fill
+        val scatterGatherDotFile = if (settings.expandedDotFile != null) settings.expandedDotFile else settings.dotFile
+        if (scatterGatherDotFile != null)
+          renderToDot(scatterGatherDotFile)
+        validate()
       }
-
-      logger.info("Removing original jobs.")
-      this.jobGraph.removeAllEdges(scatterGathers)
-      prune()
-
-      logger.info("Adding scatter gather jobs.")
-      addedFunctions.foreach(function => if (running) this.add(function))
-
-      logger.info("Regenerating graph.")
-      fill
-      val scatterGatherDotFile = if (settings.expandedDotFile != null) settings.expandedDotFile else settings.dotFile
-      if (scatterGatherDotFile != null)
-        renderToDot(scatterGatherDotFile)
-      validate()
     }
   }
 
diff --git a/public/scala/src/org/broadinstitute/sting/queue/engine/lsf/Lsf706JobRunner.scala b/public/scala/src/org/broadinstitute/sting/queue/engine/lsf/Lsf706JobRunner.scala
index 57d133dfe..ac2f036b4 100644
--- a/public/scala/src/org/broadinstitute/sting/queue/engine/lsf/Lsf706JobRunner.scala
+++ b/public/scala/src/org/broadinstitute/sting/queue/engine/lsf/Lsf706JobRunner.scala
@@ -286,11 +286,11 @@ object Lsf706JobRunner extends Logging {
     // LSB_SHAREDIR/cluster_name/logdir/lsb.acct (man bacct)
     // LSB_SHAREDIR/cluster_name/logdir/lsb.events (man bhist)
     logger.debug("Job Id %s status / exitStatus / exitInfo: ??? / ??? / ???".format(runner.jobId))
-    val unknownStatusSeconds = (System.currentTimeMillis - runner.lastStatusUpdate)
-    if (unknownStatusSeconds > (unknownStatusMaxSeconds * 1000L)) {
+    val unknownStatusMillis = (System.currentTimeMillis - runner.lastStatusUpdate)
+    if (unknownStatusMillis > (unknownStatusMaxSeconds * 1000L)) {
       // Unknown status has been returned for a while now.
       runner.updateStatus(RunnerStatus.FAILED)
-      logger.error("Unable to read LSF status for %d minutes: job id %d: %s".format(unknownStatusSeconds/60, runner.jobId, runner.function.description))
+      logger.error("Unable to read LSF status for %0.2f minutes: job id %d: %s".format(unknownStatusMillis/(60 * 1000D), runner.jobId, runner.function.description))
     }
   }
 

From 5e593793af43153e844f69c0f0df367b1d56a658 Mon Sep 17 00:00:00 2001
From: Mark DePristo <depristo@broadinstitute.org>
Date: Mon, 11 Jul 2011 23:10:27 -0400
Subject: [PATCH 57/59] DiffEngine utility function simpleDiffFiles
 printSummaryReport now uses GATKReport for nice formating Moved print
 formatting arguments into inner class provided to printing functions
 themselves, not the class BAMDiffableReader only reads 1000 entries to avoid
 performance issue.  Work around for BAM files with non-unique names
 Uncommented all of the incorrectly commented out CombineVariants
 integrationtests BaseTest now uses DiffEngine to provide inline differences
 to VCF and BAM files

---
 .../org/broadinstitute/sting/BaseTest.java    |  15 +-
 .../CombineVariantsIntegrationTest.java       | 142 +++++++++---------
 2 files changed, 83 insertions(+), 74 deletions(-)

diff --git a/public/java/test/org/broadinstitute/sting/BaseTest.java b/public/java/test/org/broadinstitute/sting/BaseTest.java
index b469c8a41..b3e422ba9 100755
--- a/public/java/test/org/broadinstitute/sting/BaseTest.java
+++ b/public/java/test/org/broadinstitute/sting/BaseTest.java
@@ -4,6 +4,7 @@ import org.apache.commons.io.FileUtils;
 import org.apache.log4j.*;
 import org.apache.log4j.spi.LoggingEvent;
 import org.broadinstitute.sting.commandline.CommandLineUtils;
+import org.broadinstitute.sting.gatk.walkers.diffengine.DiffEngine;
 import org.broadinstitute.sting.utils.exceptions.ReviewedStingException;
 import org.testng.Assert;
 
@@ -334,11 +335,14 @@ public abstract class BaseTest {
         
         if (parameterize || expectedMD5.equals("")) {
             // Don't assert
-        } else {
-            Assert.assertEquals(filemd5sum, expectedMD5, name + " Mismatching MD5s");
+        } else if ( filemd5sum.equals(expectedMD5) ) {
             System.out.println(String.format("  => %s PASSED", name));
+        } else {
+            Assert.fail(String.format("%s has mismatching MD5s: expected=%s observed=%s", name, expectedMD5, filemd5sum));
         }
 
+
+
         return filemd5sum;
     }
 
@@ -381,7 +385,12 @@ public abstract class BaseTest {
                     System.out.printf("##### Path to calculated file (MD5=%s): %s%n", filemd5sum, pathToFileMD5File);
                     System.out.printf("##### Diff command: diff %s %s%n", pathToExpectedMD5File, pathToFileMD5File);
 
-                    // todo -- add support for simple inline display of the first N differences for text file
+                    // inline differences
+                    DiffEngine.SummaryReportParams params = new DiffEngine.SummaryReportParams(System.out, 20, 10, 0);
+                    boolean success = DiffEngine.simpleDiffFiles(new File(pathToExpectedMD5File), new File(pathToFileMD5File), params);
+                    if ( success )
+                        System.out.printf("Note that the above list is not comprehensive.  At most 20 lines of output, and 10 specific differences will be listed.  Please use -T DiffObjects -R public/testdata/exampleFASTA.fasta -m %s -t %s to explore the differences more freely%n",
+                                pathToExpectedMD5File, pathToFileMD5File);
                 }
             }
 
diff --git a/public/java/test/org/broadinstitute/sting/gatk/walkers/variantutils/CombineVariantsIntegrationTest.java b/public/java/test/org/broadinstitute/sting/gatk/walkers/variantutils/CombineVariantsIntegrationTest.java
index 33a20f7b5..600718aa0 100755
--- a/public/java/test/org/broadinstitute/sting/gatk/walkers/variantutils/CombineVariantsIntegrationTest.java
+++ b/public/java/test/org/broadinstitute/sting/gatk/walkers/variantutils/CombineVariantsIntegrationTest.java
@@ -34,76 +34,76 @@ import java.util.Arrays;
  * Tests CombineVariants
  */
 public class CombineVariantsIntegrationTest extends WalkerTest {
-//    public static String baseTestString(String args) {
-//        return "-T CombineVariants -NO_HEADER -L 1:1-50,000,000 -o %s -R " + b36KGReference + args;
-//    }
-//
-//    public void test1InOut(String file, String md5, boolean vcf3) {
-//        test1InOut(file, md5, "", vcf3);
-//    }
-//
-//    public void test1InOut(String file, String md5, String args, boolean vcf3) {
-//         WalkerTestSpec spec = new WalkerTestSpec(
-//                 baseTestString(" -priority v1 -B:v1,VCF" + (vcf3 ? "3 " : " ") + validationDataLocation + file + args),
-//                 1,
-//                 Arrays.asList(md5));
-//         executeTest("testInOut1--" + file, spec);
-//    }
-//
-//    public void combine2(String file1, String file2, String args, String md5, boolean vcf3) {
-//         WalkerTestSpec spec = new WalkerTestSpec(
-//                 baseTestString(" -priority v1,v2 -B:v1,VCF" + (vcf3 ? "3 " : " ") + validationDataLocation + file1 + " -B:v2,VCF" + (vcf3 ? "3 " : " ") + validationDataLocation + file2 + args),
-//                 1,
-//                 Arrays.asList(md5));
-//         executeTest("combine2 1:" + new File(file1).getName() + " 2:" + new File(file2).getName(), spec);
-//    }
-//
-//    public void combineSites(String args, String md5) {
-//        String file1 = "1000G_omni2.5.b37.sites.vcf";
-//        String file2 = "hapmap_3.3.b37.sites.vcf";
-//        WalkerTestSpec spec = new WalkerTestSpec(
-//                "-T CombineVariants -NO_HEADER -o %s -R " + b37KGReference
-//                        + " -L 1:1-10,000,000 -B:omni,VCF " + validationDataLocation + file1
-//                        + " -B:hm3,VCF " + validationDataLocation + file2 + args,
-//                1,
-//                Arrays.asList(md5));
-//        executeTest("combineSites 1:" + new File(file1).getName() + " 2:" + new File(file2).getName() + " args = " + args, spec);
-//    }
-//
-//
-//    @Test public void test1SNP() { test1InOut("pilot2.snps.vcf4.genotypes.vcf", "2117fff6e0d182cd20be508e9661829c", true); }
-//    @Test public void test2SNP() { test1InOut("pilot2.snps.vcf4.genotypes.vcf", "2cfaf7af3dd119df08b8a9c1f72e2f93", " -setKey foo", true); }
-//    @Test public void test3SNP() { test1InOut("pilot2.snps.vcf4.genotypes.vcf", "1474ac0fde2ce42a3c24f1c97eab333e", " -setKey null", true); }
-//    @Test public void testOfficialCEUPilotCalls() { test1InOut("CEU.trio.2010_03.genotypes.vcf.gz", "7fc66df048a0ab08cf507906e1d4a308", false); } // official project VCF files in tabix format
-//
-//    @Test public void test1Indel1() { test1InOut("CEU.dindel.vcf4.trio.2010_06.indel.genotypes.vcf", "ec9715f53dbf4531570557c212822f12", false); }
-//    @Test public void test1Indel2() { test1InOut("CEU.dindel.vcf4.low_coverage.2010_06.indel.genotypes.vcf", "f1072be5f5c6ee810276d9ca6537224d", false); }
-//
-//    @Test public void combineTrioCalls() { combine2("CEU.trio.2010_03.genotypes.vcf.gz", "YRI.trio.2010_03.genotypes.vcf.gz", "", "b77a1eec725201d9d8e74ee0c45638d3", false); } // official project VCF files in tabix format
-//    @Test public void combineTrioCallsMin() { combine2("CEU.trio.2010_03.genotypes.vcf.gz", "YRI.trio.2010_03.genotypes.vcf.gz", " -minimalVCF", "802977fdfd2f4905b501bb06800f60af", false); } // official project VCF files in tabix format
-//    @Test public void combine2Indels() { combine2("CEU.dindel.vcf4.trio.2010_06.indel.genotypes.vcf", "CEU.dindel.vcf4.low_coverage.2010_06.indel.genotypes.vcf", "", "a67157287dd2b24b5cdf7ebf8fcbbe9a", false); }
-//
-//    @Test public void combineSNPsAndIndels() { combine2("CEU.trio.2010_03.genotypes.vcf.gz", "CEU.dindel.vcf4.low_coverage.2010_06.indel.genotypes.vcf", "", "e1f4718a179f1196538a33863da04f53", false); }
-//
-//    @Test public void uniqueSNPs() { combine2("pilot2.snps.vcf4.genotypes.vcf", "yri.trio.gatk_glftrio.intersection.annotated.filtered.chr1.vcf", "", "b3783384b7c8e877b971033e90beba48", true); }
-//
-//    @Test public void omniHM3Union() { combineSites(" -filteredRecordsMergeType KEEP_IF_ANY_UNFILTERED", "902e541c87caa72134db6293fc46f0ad"); }
-//    @Test public void omniHM3Intersect() { combineSites(" -filteredRecordsMergeType KEEP_IF_ALL_UNFILTERED", "f339ad4bb5863b58b9c919ce7d040bb9"); }
-//
-//    @Test public void threeWayWithRefs() {
-//        WalkerTestSpec spec = new WalkerTestSpec(
-//                baseTestString(" -B:NA19240_BGI,VCF "+validationDataLocation+"NA19240.BGI.RG.vcf" +
-//                        " -B:NA19240_ILLUMINA,VCF "+validationDataLocation+"NA19240.ILLUMINA.RG.vcf" +
-//                        " -B:NA19240_WUGSC,VCF "+validationDataLocation+"NA19240.WUGSC.RG.vcf" +
-//                        " -B:denovoInfo,VCF "+validationDataLocation+"yri_merged_validation_data_240610.annotated.b36.vcf" +
-//                        " -setKey centerSet" +
-//                        " -filteredRecordsMergeType KEEP_IF_ANY_UNFILTERED" +
-//                        " -priority NA19240_BGI,NA19240_ILLUMINA,NA19240_WUGSC,denovoInfo" +
-//                        " -genotypeMergeOptions UNIQUIFY -L 1"),
-//                1,
-//                Arrays.asList("a07995587b855f3214fb71940bf23c0f"));
-//        executeTest("threeWayWithRefs", spec);
-//    }
+    public static String baseTestString(String args) {
+        return "-T CombineVariants -NO_HEADER -L 1:1-50,000,000 -o %s -R " + b36KGReference + args;
+    }
+
+    public void test1InOut(String file, String md5, boolean vcf3) {
+        test1InOut(file, md5, "", vcf3);
+    }
+
+    public void test1InOut(String file, String md5, String args, boolean vcf3) {
+         WalkerTestSpec spec = new WalkerTestSpec(
+                 baseTestString(" -priority v1 -B:v1,VCF" + (vcf3 ? "3 " : " ") + validationDataLocation + file + args),
+                 1,
+                 Arrays.asList(md5));
+         executeTest("testInOut1--" + file, spec);
+    }
+
+    public void combine2(String file1, String file2, String args, String md5, boolean vcf3) {
+         WalkerTestSpec spec = new WalkerTestSpec(
+                 baseTestString(" -priority v1,v2 -B:v1,VCF" + (vcf3 ? "3 " : " ") + validationDataLocation + file1 + " -B:v2,VCF" + (vcf3 ? "3 " : " ") + validationDataLocation + file2 + args),
+                 1,
+                 Arrays.asList(md5));
+         executeTest("combine2 1:" + new File(file1).getName() + " 2:" + new File(file2).getName(), spec);
+    }
+
+    public void combineSites(String args, String md5) {
+        String file1 = "1000G_omni2.5.b37.sites.vcf";
+        String file2 = "hapmap_3.3.b37.sites.vcf";
+        WalkerTestSpec spec = new WalkerTestSpec(
+                "-T CombineVariants -NO_HEADER -o %s -R " + b37KGReference
+                        + " -L 1:1-10,000,000 -B:omni,VCF " + validationDataLocation + file1
+                        + " -B:hm3,VCF " + validationDataLocation + file2 + args,
+                1,
+                Arrays.asList(md5));
+        executeTest("combineSites 1:" + new File(file1).getName() + " 2:" + new File(file2).getName() + " args = " + args, spec);
+    }
+
+
+    @Test public void test1SNP() { test1InOut("pilot2.snps.vcf4.genotypes.vcf", "2117fff6e0d182cd20be508e9661829c", true); }
+    @Test public void test2SNP() { test1InOut("pilot2.snps.vcf4.genotypes.vcf", "2cfaf7af3dd119df08b8a9c1f72e2f93", " -setKey foo", true); }
+    @Test public void test3SNP() { test1InOut("pilot2.snps.vcf4.genotypes.vcf", "1474ac0fde2ce42a3c24f1c97eab333e", " -setKey null", true); }
+    @Test public void testOfficialCEUPilotCalls() { test1InOut("CEU.trio.2010_03.genotypes.vcf.gz", "7fc66df048a0ab08cf507906e1d4a308", false); } // official project VCF files in tabix format
+
+    @Test public void test1Indel1() { test1InOut("CEU.dindel.vcf4.trio.2010_06.indel.genotypes.vcf", "ec9715f53dbf4531570557c212822f12", false); }
+    @Test public void test1Indel2() { test1InOut("CEU.dindel.vcf4.low_coverage.2010_06.indel.genotypes.vcf", "f1072be5f5c6ee810276d9ca6537224d", false); }
+
+    @Test public void combineTrioCalls() { combine2("CEU.trio.2010_03.genotypes.vcf.gz", "YRI.trio.2010_03.genotypes.vcf.gz", "", "b77a1eec725201d9d8e74ee0c45638d3", false); } // official project VCF files in tabix format
+    @Test public void combineTrioCallsMin() { combine2("CEU.trio.2010_03.genotypes.vcf.gz", "YRI.trio.2010_03.genotypes.vcf.gz", " -minimalVCF", "802977fdfd2f4905b501bb06800f60af", false); } // official project VCF files in tabix format
+    @Test public void combine2Indels() { combine2("CEU.dindel.vcf4.trio.2010_06.indel.genotypes.vcf", "CEU.dindel.vcf4.low_coverage.2010_06.indel.genotypes.vcf", "", "a67157287dd2b24b5cdf7ebf8fcbbe9a", false); }
+
+    @Test public void combineSNPsAndIndels() { combine2("CEU.trio.2010_03.genotypes.vcf.gz", "CEU.dindel.vcf4.low_coverage.2010_06.indel.genotypes.vcf", "", "e1f4718a179f1196538a33863da04f53", false); }
+
+    @Test public void uniqueSNPs() { combine2("pilot2.snps.vcf4.genotypes.vcf", "yri.trio.gatk_glftrio.intersection.annotated.filtered.chr1.vcf", "", "b3783384b7c8e877b971033e90beba48", true); }
+
+    @Test public void omniHM3Union() { combineSites(" -filteredRecordsMergeType KEEP_IF_ANY_UNFILTERED", "902e541c87caa72134db6293fc46f0ad"); }
+    @Test public void omniHM3Intersect() { combineSites(" -filteredRecordsMergeType KEEP_IF_ALL_UNFILTERED", "f339ad4bb5863b58b9c919ce7d040bb9"); }
+
+    @Test public void threeWayWithRefs() {
+        WalkerTestSpec spec = new WalkerTestSpec(
+                baseTestString(" -B:NA19240_BGI,VCF "+validationDataLocation+"NA19240.BGI.RG.vcf" +
+                        " -B:NA19240_ILLUMINA,VCF "+validationDataLocation+"NA19240.ILLUMINA.RG.vcf" +
+                        " -B:NA19240_WUGSC,VCF "+validationDataLocation+"NA19240.WUGSC.RG.vcf" +
+                        " -B:denovoInfo,VCF "+validationDataLocation+"yri_merged_validation_data_240610.annotated.b36.vcf" +
+                        " -setKey centerSet" +
+                        " -filteredRecordsMergeType KEEP_IF_ANY_UNFILTERED" +
+                        " -priority NA19240_BGI,NA19240_ILLUMINA,NA19240_WUGSC,denovoInfo" +
+                        " -genotypeMergeOptions UNIQUIFY -L 1"),
+                1,
+                Arrays.asList("a07995587b855f3214fb71940bf23c0f"));
+        executeTest("threeWayWithRefs", spec);
+    }
 
 
     // complex examples with filtering, indels, and multiple alleles
@@ -119,7 +119,7 @@ public class CombineVariantsIntegrationTest extends WalkerTest {
         executeTest("combineComplexSites 1:" + new File(file1).getName() + " 2:" + new File(file2).getName() + " args = " + args, spec);
     }
 
-    @Test public void complexTestFull() { combineComplexSites("", "64b991fd3850f83614518f7d71f0532f"); }
+//    @Test public void complexTestFull() { combineComplexSites("", "64b991fd3850f83614518f7d71f0532f"); }
     @Test public void complexTestMinimal() { combineComplexSites(" -minimalVCF", "0db9ef50fe54b60426474273d7c7fa99"); }
     @Test public void complexTestSitesOnly() { combineComplexSites(" -sites_only", "d20acb3d53ba0a02ce92d540ebeda2a9"); }
     @Test public void complexTestSitesOnlyMinimal() { combineComplexSites(" -sites_only -minimalVCF", "8d1b3d120515f8b56b5a0d10bc5da713"); }

From 893cc2e103e25daf01018c86382869ddac0e1f4a Mon Sep 17 00:00:00 2001
From: Mark DePristo <depristo@broadinstitute.org>
Date: Mon, 11 Jul 2011 23:15:08 -0400
Subject: [PATCH 58/59] Making the package public, so there's no dependances
 from public -> private

---
 .../walkers/diffengine/BAMDiffableReader.java | 122 +++++
 .../gatk/walkers/diffengine/DiffElement.java  | 118 +++++
 .../gatk/walkers/diffengine/DiffEngine.java   | 423 ++++++++++++++++++
 .../gatk/walkers/diffengine/DiffNode.java     | 239 ++++++++++
 .../walkers/diffengine/DiffObjectsWalker.java | 113 +++++
 .../gatk/walkers/diffengine/DiffValue.java    |  90 ++++
 .../walkers/diffengine/DiffableReader.java    |  50 +++
 .../gatk/walkers/diffengine/Difference.java   |  58 +++
 .../walkers/diffengine/VCFDiffableReader.java | 119 +++++
 9 files changed, 1332 insertions(+)
 create mode 100644 public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/BAMDiffableReader.java
 create mode 100644 public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffElement.java
 create mode 100644 public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffEngine.java
 create mode 100644 public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffNode.java
 create mode 100644 public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffObjectsWalker.java
 create mode 100644 public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffValue.java
 create mode 100644 public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffableReader.java
 create mode 100644 public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/Difference.java
 create mode 100644 public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/VCFDiffableReader.java

diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/BAMDiffableReader.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/BAMDiffableReader.java
new file mode 100644
index 000000000..f7a395d9d
--- /dev/null
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/BAMDiffableReader.java
@@ -0,0 +1,122 @@
+/*
+ * Copyright (c) 2011, The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR
+ * OTHER DEALINGS IN THE SOFTWARE.
+ */
+
+package org.broadinstitute.sting.gatk.walkers.diffengine;
+
+import net.sf.samtools.*;
+import net.sf.samtools.util.BlockCompressedInputStream;
+import org.broad.tribble.readers.AsciiLineReader;
+import org.broad.tribble.readers.LineReader;
+import org.broadinstitute.sting.utils.codecs.vcf.VCFCodec;
+import org.broadinstitute.sting.utils.codecs.vcf.VCFHeader;
+import org.broadinstitute.sting.utils.variantcontext.Genotype;
+import org.broadinstitute.sting.utils.variantcontext.VariantContext;
+
+import java.io.DataInputStream;
+import java.io.File;
+import java.io.FileInputStream;
+import java.io.IOException;
+import java.util.Arrays;
+import java.util.Map;
+import java.util.zip.GZIPInputStream;
+
+
+/**
+ * Created by IntelliJ IDEA.
+ * User: depristo
+ * Date: 7/4/11
+ * Time: 1:09 PM
+ *
+ * Class implementing diffnode reader for VCF
+ */
+public class BAMDiffableReader implements DiffableReader {
+    private final static int MAX_RECORDS_TO_READ = 1000;
+    @Override
+    public String getName() { return "BAM"; }
+
+    @Override
+    public DiffElement readFromFile(File file) {
+        final SAMFileReader reader = new SAMFileReader(file, null); // null because we don't want it to look for the index
+        reader.setValidationStringency(SAMFileReader.ValidationStringency.SILENT);
+
+        DiffNode root = DiffNode.rooted(file.getName());
+        SAMRecordIterator iterator = reader.iterator();
+
+        int count = 0;
+        while ( iterator.hasNext() ) {
+            if ( count++ > MAX_RECORDS_TO_READ )
+                break;
+            final SAMRecord record = iterator.next();
+
+            // name is the read name + first of pair
+            String name = record.getReadName().replace('.', '_');
+            if ( record.getReadPairedFlag() ) {
+                name += record.getFirstOfPairFlag() ? "_1" : "_2";
+            }
+
+            DiffNode readRoot = DiffNode.empty(name, root);
+
+            // add fields
+            readRoot.add("NAME", record.getReadName());
+            readRoot.add("FLAGS", record.getFlags());
+            readRoot.add("RNAME", record.getReferenceName());
+            readRoot.add("POS", record.getAlignmentStart());
+            readRoot.add("MAPQ", record.getMappingQuality());
+            readRoot.add("CIGAR", record.getCigarString());
+            readRoot.add("RNEXT", record.getMateReferenceName());
+            readRoot.add("PNEXT", record.getMateAlignmentStart());
+            readRoot.add("TLEN", record.getInferredInsertSize());
+            readRoot.add("SEQ", record.getReadString());
+            readRoot.add("QUAL", record.getBaseQualityString());
+
+            for ( SAMRecord.SAMTagAndValue xt : record.getAttributes() ) {
+                readRoot.add(xt.tag, xt.value);
+            }
+
+            // add record to root
+            if ( ! root.hasElement(name) )
+                // protect ourselves from malformed files
+                root.add(readRoot);
+        }
+
+        reader.close();
+
+        return root.getBinding();
+    }
+
+    @Override
+    public boolean canRead(File file) {
+        final byte[] BAM_MAGIC = "BAM\1".getBytes();
+        final byte[] buffer = new byte[BAM_MAGIC.length];
+        try {
+            FileInputStream fstream = new FileInputStream(file);
+            new BlockCompressedInputStream(fstream).read(buffer,0,BAM_MAGIC.length);
+            return Arrays.equals(buffer, BAM_MAGIC);
+        } catch ( IOException e ) {
+            return false;
+        } catch ( net.sf.samtools.FileTruncatedException e ) {
+            return false;
+        }
+    }
+}
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffElement.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffElement.java
new file mode 100644
index 000000000..eff24bb88
--- /dev/null
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffElement.java
@@ -0,0 +1,118 @@
+/*
+ * Copyright (c) 2011, The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR
+ * OTHER DEALINGS IN THE SOFTWARE.
+ */
+
+package org.broadinstitute.sting.gatk.walkers.diffengine;
+
+import com.google.java.contract.*;
+import org.broadinstitute.sting.utils.Utils;
+import org.broadinstitute.sting.utils.exceptions.ReviewedStingException;
+
+/**
+ * Created by IntelliJ IDEA.
+ * User: depristo
+ * Date: 7/4/11
+ * Time: 12:55 PM
+ *
+ * An interface that must be implemented to allow us to calculate differences
+ * between structured objects
+ */
+@Invariant({
+        "name != null",
+        "value != null",
+        "parent != null || name.equals(\"ROOT\")",
+        "value == null || value.getBinding() == this"})
+public class DiffElement {
+    public final static DiffElement ROOT = new DiffElement();
+
+    final private String name;
+    final private DiffElement parent;
+    final private DiffValue value;
+
+    /**
+     * For ROOT only
+     */
+    private DiffElement() {
+        this.name = "ROOT";
+        this.parent = null;
+        this.value = new DiffValue(this, "ROOT");
+    }
+
+    @Requires({"name != null", "parent != null", "value != null"})
+    public DiffElement(String name, DiffElement parent, DiffValue value) {
+        if ( name.equals("ROOT") ) throw new IllegalArgumentException("Cannot use reserved name ROOT");
+        this.name = name;
+        this.parent = parent;
+        this.value = value;
+        this.value.setBinding(this);
+    }
+
+    @Ensures({"result != null"})
+    public String getName() {
+        return name;
+    }
+
+    public DiffElement getParent() {
+        return parent;
+    }
+
+    @Ensures({"result != null"})
+    public DiffValue getValue() {
+        return value;
+    }
+
+    public boolean isRoot() { return this == ROOT; }
+
+    @Ensures({"result != null"})
+    @Override
+    public String toString() {
+        return getName() + "=" + getValue().toString();
+    }
+
+    public String toString(int offset) {
+        return (offset > 0 ? Utils.dupString(' ', offset) : 0) + getName() + "=" + getValue().toString(offset);
+    }
+
+    @Ensures({"result != null"})
+    public final String fullyQualifiedName() {
+        if ( isRoot() )
+            return "";
+        else if ( parent.isRoot() )
+            return name;
+        else
+            return parent.fullyQualifiedName() + "." + name;
+    }
+
+    @Ensures({"result != null"})
+    public String toOneLineString() {
+        return getName() + "=" + getValue().toOneLineString();
+    }
+
+    @Ensures({"result != null"})
+    public DiffNode getValueAsNode() {
+        if ( getValue().isCompound() )
+            return (DiffNode)getValue();
+        else
+            throw new ReviewedStingException("Illegal request conversion of a DiffValue into a DiffNode: " + this);
+    }
+}
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffEngine.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffEngine.java
new file mode 100644
index 000000000..ba2713bff
--- /dev/null
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffEngine.java
@@ -0,0 +1,423 @@
+/*
+ * Copyright (c) 2011, The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR
+ * OTHER DEALINGS IN THE SOFTWARE.
+ */
+
+package org.broadinstitute.sting.gatk.walkers.diffengine;
+
+import com.google.java.contract.Requires;
+import org.apache.log4j.Logger;
+import org.broadinstitute.sting.gatk.report.GATKReport;
+import org.broadinstitute.sting.gatk.report.GATKReportTable;
+import org.broadinstitute.sting.gatk.walkers.varianteval.stratifications.VariantStratifier;
+import org.broadinstitute.sting.utils.Utils;
+import org.broadinstitute.sting.utils.classloader.PluginManager;
+import org.broadinstitute.sting.utils.exceptions.ReviewedStingException;
+import org.broadinstitute.sting.utils.exceptions.UserException;
+
+import java.io.File;
+import java.io.PrintStream;
+import java.util.*;
+
+/**
+ * Created by IntelliJ IDEA.
+ * User: depristo
+ * Date: 7/4/11
+ * Time: 12:51 PM
+ * A generic engine for comparing tree-structured objects
+ */
+public class DiffEngine {
+    final protected static Logger logger = Logger.getLogger(DiffEngine.class);
+
+    private final Map<String, DiffableReader> readers = new HashMap<String, DiffableReader>();
+
+    public DiffEngine() {
+        loadDiffableReaders();
+    }
+
+    // --------------------------------------------------------------------------------
+    //
+    // difference calculation
+    //
+    // --------------------------------------------------------------------------------
+
+    public List<Difference> diff(DiffElement master, DiffElement test) {
+        DiffValue masterValue = master.getValue();
+        DiffValue testValue = test.getValue();
+
+        if ( masterValue.isCompound() && masterValue.isCompound() ) {
+            return diff(master.getValueAsNode(), test.getValueAsNode());
+        } else if ( masterValue.isAtomic() && testValue.isAtomic() ) {
+            return diff(masterValue, testValue);
+        } else {
+            // structural difference in types.  one is node, other is leaf
+            return Arrays.asList(new Difference(master, test));
+        }
+    }
+
+    public List<Difference> diff(DiffNode master, DiffNode test) {
+        Set<String> allNames = new HashSet<String>(master.getElementNames());
+        allNames.addAll(test.getElementNames());
+        List<Difference> diffs = new ArrayList<Difference>();
+
+        for ( String name : allNames ) {
+            DiffElement masterElt = master.getElement(name);
+            DiffElement testElt = test.getElement(name);
+            if ( masterElt == null && testElt == null ) {
+                throw new ReviewedStingException("BUG: unexceptedly got two null elements for field: " + name);
+            } else if ( masterElt == null || testElt == null ) { // if either is null, we are missing a value
+                // todo -- should one of these be a special MISSING item?
+                diffs.add(new Difference(masterElt, testElt));
+            } else {
+                diffs.addAll(diff(masterElt, testElt));
+            }
+        }
+
+        return diffs;
+    }
+
+    public List<Difference> diff(DiffValue master, DiffValue test) {
+        if ( master.getValue().equals(test.getValue()) ) {
+            return Collections.emptyList();
+        } else {
+            return Arrays.asList(new Difference(master.getBinding(), test.getBinding()));
+        }
+    }
+
+    // --------------------------------------------------------------------------------
+    //
+    // Summarizing differences
+    //
+    // --------------------------------------------------------------------------------
+
+    /**
+     * Emits a summary of the diffs to out.  Suppose you have the following three differences:
+     *
+     *   A.X.Z:1!=2
+     *   A.Y.Z:3!=4
+     *   B.X.Z:5!=6
+     *
+     * The above is the itemized list of the differences.  The summary looks for common differences
+     * in the name hierarchy, counts those shared elements, and emits the differences that occur
+     * in order of decreasing counts.
+     *
+     * So, in the above example, what are the shared elements?
+     *
+     * A.X.Z and B.X.Z share X.Z, so there's a *.X.Z with count 2
+     * A.X.Z, A.Y.Z, and B.X.Z all share *.*.Z, with count 3
+     * Each of A.X.Z, A.Y.Z, and B.X.Z are individually unique, with count 1
+     *
+     * So we would emit the following summary:
+     *
+     * *.*.Z: 3
+     * *.X.Z: 2
+     * A.X.Z: 1 [specific difference: 1!=2]
+     * A.Y.Z: 1 [specific difference: 3!=4]
+     * B.X.Z: 1 [specific difference: 5!=6]
+     *
+     * The algorithm to accomplish this calculation is relatively simple. Start with all of the
+     * concrete differences.  For each pair of differences A1.A2....AN and B1.B2....BN:
+     *
+     * find the longest common subsequence Si.Si+1...SN where Ai = Bi = Si
+     * If i == 0, then there's no shared substructure
+     * If i > 0, then generate the summarized value X = *.*...Si.Si+1...SN
+     * if X is a known summary, increment it's count, otherwise set its count to 1
+     *
+     * Not that only pairs of the same length are considered as potentially equivalent
+     *
+     * @param params determines how we display the items
+     * @param diffs
+     */
+    public void reportSummarizedDifferences(List<Difference> diffs, SummaryReportParams params ) {
+        printSummaryReport(summarizeDifferences(diffs), params );
+    }
+
+    public List<SummarizedDifference> summarizeDifferences(List<Difference> diffs) {
+        List<String[]> diffPaths = new ArrayList<String[]>(diffs.size());
+
+        for ( Difference diff1 : diffs ) {
+            diffPaths.add(diffNameToPath(diff1.getFullyQualifiedName()));
+        }
+
+        return summarizedDifferencesOfPaths(diffPaths);
+    }
+
+    final protected static String[] diffNameToPath(String diffName) {
+        return diffName.split("\\.");
+    }
+
+    protected List<SummarizedDifference> summarizedDifferencesOfPaths(List<String[]> diffPaths) {
+        Map<String, SummarizedDifference> summaries = new HashMap<String, SummarizedDifference>();
+
+        // create the initial set of differences
+        for ( int i = 0; i < diffPaths.size(); i++ ) {
+            for ( int j = 0; j <= i; j++ ) {
+                String[] diffPath1 = diffPaths.get(i);
+                String[] diffPath2 = diffPaths.get(j);
+                if ( diffPath1.length == diffPath2.length ) {
+                    int lcp = longestCommonPostfix(diffPath1, diffPath2);
+                    String path = lcp > 0 ? summarizedPath(diffPath2, lcp) : Utils.join(".", diffPath2);
+                    addSummary(summaries, path, true);
+                }
+            }
+        }
+
+        // count differences
+        for ( String[] diffPath : diffPaths ) {
+            for ( SummarizedDifference sumDiff : summaries.values() ) {
+                if ( sumDiff.matches(diffPath) )
+                    addSummary(summaries, sumDiff.getPath(), false);
+            }
+        }
+
+        List<SummarizedDifference> sortedSummaries = new ArrayList<SummarizedDifference>(summaries.values());
+        Collections.sort(sortedSummaries);
+        return sortedSummaries;
+    }
+
+    private static void addSummary(Map<String, SummarizedDifference> summaries, String path, boolean onlyCatalog) {
+        if ( summaries.containsKey(path) ) {
+            if ( ! onlyCatalog )
+                summaries.get(path).incCount();
+        } else {
+            SummarizedDifference sumDiff = new SummarizedDifference(path);
+            summaries.put(sumDiff.getPath(), sumDiff);
+        }
+    }
+
+    protected void printSummaryReport(List<SummarizedDifference> sortedSummaries, SummaryReportParams params ) {
+        GATKReport report = new GATKReport();
+        final String tableName = "diffences";
+        report.addTable(tableName, "Summarized differences between the master and test files.\nSee http://www.broadinstitute.org/gsa/wiki/index.php/DiffObjectsWalker_and_SummarizedDifferences for more information");
+        GATKReportTable table = report.getTable(tableName);
+        table.addPrimaryKey("Difference", true);
+        table.addColumn("NumberOfOccurrences", 0);
+
+        int count = 0, count1 = 0;
+        for ( SummarizedDifference diff : sortedSummaries ) {
+            if ( diff.getCount() < params.minSumDiffToShow )
+                // in order, so break as soon as the count is too low
+                break;
+
+            if ( params.maxItemsToDisplay != 0 && count++ > params.maxItemsToDisplay )
+                break;
+
+            if ( diff.getCount() == 1 ) {
+                count1++;
+                if ( params.maxCountOneItems != 0 && count1 > params.maxCountOneItems )
+                    break;
+            }
+
+            table.set(diff.getPath(), "NumberOfOccurrences", diff.getCount());
+        }
+
+        table.write(params.out);
+    }
+
+    protected static int longestCommonPostfix(String[] diffPath1, String[] diffPath2) {
+        int i = 0;
+        for ( ; i < diffPath1.length; i++ ) {
+            int j = diffPath1.length - i - 1;
+            if ( ! diffPath1[j].equals(diffPath2[j]) )
+                break;
+        }
+        return i;
+    }
+
+    /**
+     * parts is [A B C D]
+     * commonPostfixLength: how many parts are shared at the end, suppose its 2
+     * We want to create a string *.*.C.D
+     *
+     * @param parts
+     * @param commonPostfixLength
+     * @return
+     */
+    protected static String summarizedPath(String[] parts, int commonPostfixLength) {
+        int stop = parts.length - commonPostfixLength;
+        if ( stop > 0 ) parts = parts.clone();
+        for ( int i = 0; i < stop; i++ ) {
+            parts[i] = "*";
+        }
+        return Utils.join(".", parts);
+    }
+
+    /**
+     * TODO -- all of the algorithms above should use SummarizedDifference instead
+     * TODO -- of some SummarizedDifferences and some low-level String[]
+     */
+    public static class SummarizedDifference implements Comparable<SummarizedDifference> {
+        final String path; // X.Y.Z
+        final String[] parts;
+        int count = 0;
+
+        public SummarizedDifference(String path) {
+            this.path = path;
+            this.parts = diffNameToPath(path);
+        }
+
+        public void incCount() { count++; }
+
+        public int getCount() {
+            return count;
+        }
+
+        /**
+         * The fully qualified path object A.B.C etc
+         * @return
+         */
+        public String getPath() {
+            return path;
+        }
+
+        /**
+         * @return the length of the parts of this summary
+         */
+        public int length() {
+            return this.parts.length;
+        }
+
+        /**
+         * Returns true if the string parts matches this summary.  Matches are
+         * must be equal() everywhere where this summary isn't *.
+         * @param otherParts
+         * @return
+         */
+        public boolean matches(String[] otherParts) {
+            if ( otherParts.length != length() )
+                return false;
+
+            // TODO optimization: can start at right most non-star element
+            for ( int i = 0; i < length(); i++ ) {
+                String part = parts[i];
+                if ( ! part.equals("*") && ! part.equals(otherParts[i]) )
+                    return false;
+            }
+
+            return true;
+        }
+
+        @Override
+        public String toString() {
+            return String.format("%s:%d", getPath(), getCount());
+        }
+
+        @Override
+        public int compareTo(SummarizedDifference other) {
+            // sort first highest to lowest count, then by lowest to highest path
+            int countCmp = Integer.valueOf(count).compareTo(other.count);
+            return countCmp != 0 ? -1 * countCmp : path.compareTo(other.path);
+        }
+
+
+    }
+
+    // --------------------------------------------------------------------------------
+    //
+    // plugin manager
+    //
+    // --------------------------------------------------------------------------------
+
+    public void loadDiffableReaders() {
+        List<Class<? extends DiffableReader>> drClasses = new PluginManager<DiffableReader>( DiffableReader.class ).getPlugins();
+
+        logger.info("Loading diffable modules:");
+        for (Class<? extends DiffableReader> drClass : drClasses ) {
+            logger.info("\t" + drClass.getSimpleName());
+
+            try {
+                DiffableReader dr = drClass.newInstance();
+                readers.put(dr.getName(), dr);
+            } catch (InstantiationException e) {
+                throw new ReviewedStingException("Unable to instantiate module '" + drClass.getSimpleName() + "'");
+            } catch (IllegalAccessException e) {
+                throw new ReviewedStingException("Illegal access error when trying to instantiate '" + drClass.getSimpleName() + "'");
+            }
+        }
+    }
+
+    protected Map<String, DiffableReader> getReaders() {
+        return readers;
+    }
+
+    protected DiffableReader getReader(String name) {
+        return readers.get(name);
+    }
+
+    /**
+     * Returns a reader appropriate for this file, or null if no such reader exists
+     * @param file
+     * @return
+     */
+    public DiffableReader findReaderForFile(File file) {
+        for ( DiffableReader reader : readers.values() )
+            if (reader.canRead(file) )
+                return reader;
+
+        return null;
+    }
+
+    /**
+     * Returns true if reader appropriate for this file, or false if no such reader exists
+     * @param file
+     * @return
+     */
+    public boolean canRead(File file) {
+        return findReaderForFile(file) != null;
+    }
+
+    public DiffElement createDiffableFromFile(File file) {
+        DiffableReader reader = findReaderForFile(file);
+        if ( reader == null )
+            throw new UserException("Unsupported file type: " + file);
+        else
+            return reader.readFromFile(file);
+    }
+
+    public static boolean simpleDiffFiles(File masterFile, File testFile, DiffEngine.SummaryReportParams params) {
+        DiffEngine diffEngine = new DiffEngine();
+
+        if ( diffEngine.canRead(masterFile) && diffEngine.canRead(testFile) ) {
+            DiffElement master = diffEngine.createDiffableFromFile(masterFile);
+            DiffElement test = diffEngine.createDiffableFromFile(testFile);
+            List<Difference> diffs = diffEngine.diff(master, test);
+            diffEngine.reportSummarizedDifferences(diffs, params);
+            return true;
+        } else {
+            return false;
+        }
+    }
+
+    public static class SummaryReportParams {
+        PrintStream out = System.out;
+        int maxItemsToDisplay = 0;
+        int maxCountOneItems = 0;
+        int minSumDiffToShow = 0;
+
+        public SummaryReportParams(PrintStream out, int maxItemsToDisplay, int maxCountOneItems, int minSumDiffToShow) {
+            this.out = out;
+            this.maxItemsToDisplay = maxItemsToDisplay;
+            this.maxCountOneItems = maxCountOneItems;
+            this.minSumDiffToShow = minSumDiffToShow;
+        }
+    }
+}
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffNode.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffNode.java
new file mode 100644
index 000000000..0720e18c0
--- /dev/null
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffNode.java
@@ -0,0 +1,239 @@
+/*
+ * Copyright (c) 2011, The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR
+ * OTHER DEALINGS IN THE SOFTWARE.
+ */
+
+package org.broadinstitute.sting.gatk.walkers.diffengine;
+
+import com.google.java.contract.Requires;
+import org.broadinstitute.sting.utils.Utils;
+import org.broadinstitute.sting.utils.exceptions.ReviewedStingException;
+
+import java.util.*;
+
+/**
+ * Created by IntelliJ IDEA.
+ * User: depristo
+ * Date: 7/4/11
+ * Time: 12:55 PM
+ *
+ * An interface that must be implemented to allow us to calculate differences
+ * between structured objects
+ */
+public class DiffNode extends DiffValue {
+    private Map<String, DiffElement> getElementMap() {
+        return (Map<String, DiffElement>)super.getValue();
+    }
+    private static Map<String, DiffElement> emptyElements() { return new HashMap<String, DiffElement>(); }
+
+    private DiffNode(Map<String, DiffElement> elements) {
+        super(elements);
+    }
+
+    private DiffNode(DiffElement binding, Map<String, DiffElement> elements) {
+        super(binding, elements);
+    }
+
+    // ---------------------------------------------------------------------------
+    //
+    // constructors
+    //
+    // ---------------------------------------------------------------------------
+
+    public static DiffNode rooted(String name) {
+        return empty(name, DiffElement.ROOT);
+    }
+
+    public static DiffNode empty(String name, DiffElement parent) {
+        DiffNode df = new DiffNode(emptyElements());
+        DiffElement elt = new DiffElement(name, parent, df);
+        df.setBinding(elt);
+        return df;
+    }
+
+    public static DiffNode empty(String name, DiffValue parent) {
+        return empty(name, parent.getBinding());
+    }
+
+    // ---------------------------------------------------------------------------
+    //
+    // accessors
+    //
+    // ---------------------------------------------------------------------------
+
+    @Override
+    public boolean isAtomic() { return false; }
+
+    public Collection<String> getElementNames() {
+        return getElementMap().keySet();
+    }
+
+    public Collection<DiffElement> getElements() {
+        return getElementMap().values();
+    }
+
+    private Collection<DiffElement> getElements(boolean atomicOnly) {
+        List<DiffElement> elts = new ArrayList<DiffElement>();
+        for ( DiffElement elt : getElements() )
+            if ( (atomicOnly && elt.getValue().isAtomic()) || (! atomicOnly && elt.getValue().isCompound()))
+                elts.add(elt);
+        return elts;
+    }
+
+    public Collection<DiffElement> getAtomicElements() {
+        return getElements(true);
+    }
+
+    public Collection<DiffElement> getCompoundElements() {
+        return getElements(false);
+    }
+
+    public DiffElement getElement(String name) {
+        for ( DiffElement elt : getElements() )
+            if ( elt.getName().equals(name) )
+                return elt;
+        return null;
+    }
+
+    /**
+     * Returns true if name is bound in this node
+     * @param name
+     * @return
+     */
+    public boolean hasElement(String name) {
+        return getElement(name) != null;
+    }
+
+    // ---------------------------------------------------------------------------
+    //
+    // add
+    //
+    // ---------------------------------------------------------------------------
+
+    @Requires("elt != null")
+    public void add(DiffElement elt) {
+        if ( getElementMap().containsKey(elt.getName()) )
+            throw new IllegalArgumentException("Attempting to rebind already existing binding: " + elt + " node=" + this);
+        getElementMap().put(elt.getName(), elt);
+    }
+
+    @Requires("elt != null")
+    public void add(DiffValue elt) {
+        add(elt.getBinding());
+    }
+
+    @Requires("elts != null")
+    public void add(Collection<DiffElement> elts) {
+        for ( DiffElement e : elts )
+            add(e);
+    }
+
+    public void add(String name, Object value) {
+        add(new DiffElement(name, this.getBinding(), new DiffValue(value)));
+    }
+
+    // ---------------------------------------------------------------------------
+    //
+    // toString
+    //
+    // ---------------------------------------------------------------------------
+
+    @Override
+    public String toString() {
+        return toString(0);
+    }
+
+    @Override
+    public String toString(int offset) {
+        String off = offset > 0 ? Utils.dupString(' ', offset) : "";
+        StringBuilder b = new StringBuilder();
+
+        b.append("(").append("\n");
+        Collection<DiffElement> atomicElts = getAtomicElements();
+        for ( DiffElement elt : atomicElts ) {
+            b.append(elt.toString(offset + 2)).append('\n');
+        }
+
+        for ( DiffElement elt : getCompoundElements() ) {
+            b.append(elt.toString(offset + 4)).append('\n');
+        }
+        b.append(off).append(")").append("\n");
+
+        return b.toString();
+    }
+
+    @Override
+    public String toOneLineString() {
+        StringBuilder b = new StringBuilder();
+
+        b.append('(');
+        List<String> parts = new ArrayList<String>();
+        for ( DiffElement elt : getElements() )
+            parts.add(elt.toOneLineString());
+        b.append(Utils.join(" ", parts));
+        b.append(')');
+
+        return b.toString();
+    }
+
+    // --------------------------------------------------------------------------------
+    //
+    // fromString and toOneLineString
+    //
+    // --------------------------------------------------------------------------------
+
+    public static DiffElement fromString(String tree) {
+        return fromString(tree, DiffElement.ROOT);
+    }
+
+    /**
+     * Doesn't support full tree structure parsing
+     * @param tree
+     * @param parent
+     * @return
+     */
+    private static DiffElement fromString(String tree, DiffElement parent) {
+        // X=(A=A B=B C=(D=D))
+        String[] parts = tree.split("=", 2);
+        if ( parts.length != 2 )
+            throw new ReviewedStingException("Unexpected tree structure: " + tree + " parts=" + parts);
+        String name = parts[0];
+        String value = parts[1];
+
+        if ( value.length() == 0 )
+            throw new ReviewedStingException("Illegal tree structure: " + value + " at " + tree);
+
+        if ( value.charAt(0) == '(' ) {
+            if ( ! value.endsWith(")") )
+                throw new ReviewedStingException("Illegal tree structure.  Missing ): " + value + " at " + tree);
+            String subtree = value.substring(1, value.length()-1);
+            DiffNode rec = DiffNode.empty(name, parent);
+            String[] subParts = subtree.split(" ");
+            for ( String subPart : subParts ) {
+                rec.add(fromString(subPart, rec.getBinding()));
+            }
+            return rec.getBinding();
+        } else {
+            return new DiffValue(name, parent, value).getBinding();
+        }
+    }
+}
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffObjectsWalker.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffObjectsWalker.java
new file mode 100644
index 000000000..a08108db2
--- /dev/null
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffObjectsWalker.java
@@ -0,0 +1,113 @@
+/*
+ * Copyright (c) 2011, The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR
+ * OTHER DEALINGS IN THE SOFTWARE.
+ */
+
+package org.broadinstitute.sting.gatk.walkers.diffengine;
+
+import org.apache.xmlbeans.impl.tool.Diff;
+import org.broadinstitute.sting.commandline.Argument;
+import org.broadinstitute.sting.commandline.Output;
+import org.broadinstitute.sting.gatk.contexts.AlignmentContext;
+import org.broadinstitute.sting.gatk.contexts.ReferenceContext;
+import org.broadinstitute.sting.gatk.refdata.RefMetaDataTracker;
+import org.broadinstitute.sting.gatk.walkers.Requires;
+import org.broadinstitute.sting.gatk.walkers.RodWalker;
+
+import java.io.File;
+import java.io.PrintStream;
+import java.util.List;
+
+/**
+ * Compares two record-oriented files, itemizing specific difference between equivalent
+ * records in the two files.  Reports both itemized and summarized differences.
+ * @author Mark DePristo
+ * @version 0.1
+ */
+@Requires(value={})
+public class DiffObjectsWalker extends RodWalker<Integer, Integer> {
+    @Output(doc="File to which results should be written",required=true)
+    protected PrintStream out;
+
+    @Argument(fullName="maxRecords", shortName="M", doc="Max. number of records to process", required=false)
+    int MAX_RECORDS = 0;
+
+    @Argument(fullName="maxCount1Records", shortName="M1", doc="Max. number of records occuring exactly once in the file to process", required=false)
+    int MAX_COUNT1_RECORDS = 0;
+
+    @Argument(fullName="minCountForDiff", shortName="MCFD", doc="Min number of observations for a records to display", required=false)
+    int minCountForDiff = 1;
+
+    @Argument(fullName="showItemizedDifferences", shortName="SID", doc="Should we enumerate all differences between the files?", required=false)
+    boolean showItemizedDifferences = false;
+
+    @Argument(fullName="master", shortName="m", doc="Master file: expected results", required=true)
+    File masterFile;
+
+    @Argument(fullName="test", shortName="t", doc="Test file: new results to compare to the master file", required=true)
+    File testFile;
+
+    final DiffEngine diffEngine = new DiffEngine();
+
+    @Override
+    public void initialize() {
+
+    }
+
+    @Override
+    public Integer map(RefMetaDataTracker tracker, ReferenceContext ref, AlignmentContext context) {
+        return 0;
+    }
+
+    @Override
+    public Integer reduceInit() {
+        return 0;
+    }
+
+    @Override
+    public Integer reduce(Integer counter, Integer sum) {
+        return counter + sum;
+    }
+
+    @Override
+    public void onTraversalDone(Integer sum) {
+        out.printf("Reading master file %s%n", masterFile);
+        DiffElement master = diffEngine.createDiffableFromFile(masterFile);
+        out.printf("Reading test file %s%n", testFile);
+        DiffElement test = diffEngine.createDiffableFromFile(testFile);
+
+//        out.printf("Master diff objects%n");
+//        out.println(master.toString());
+//        out.printf("Test diff objects%n");
+//        out.println(test.toString());
+
+        List<Difference> diffs = diffEngine.diff(master, test);
+        if ( showItemizedDifferences ) {
+            out.printf("Itemized results%n");
+            for ( Difference diff : diffs )
+                out.printf("DIFF: %s%n", diff.toString());
+        }
+
+        DiffEngine.SummaryReportParams params = new DiffEngine.SummaryReportParams(out, MAX_RECORDS, MAX_COUNT1_RECORDS, minCountForDiff);
+        diffEngine.reportSummarizedDifferences(diffs, params);
+    }
+}
\ No newline at end of file
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffValue.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffValue.java
new file mode 100644
index 000000000..7245e9e8d
--- /dev/null
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffValue.java
@@ -0,0 +1,90 @@
+/*
+ * Copyright (c) 2011, The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR
+ * OTHER DEALINGS IN THE SOFTWARE.
+ */
+
+package org.broadinstitute.sting.gatk.walkers.diffengine;
+
+import org.broadinstitute.sting.utils.Utils;
+
+/**
+ * Created by IntelliJ IDEA.
+ * User: depristo
+ * Date: 7/4/11
+ * Time: 12:55 PM
+ *
+ * An interface that must be implemented to allow us to calculate differences
+ * between structured objects
+ */
+public class DiffValue {
+    private DiffElement binding = null;
+    final private Object value;
+
+    public DiffValue(Object value) {
+        this.value = value;
+    }
+
+    public DiffValue(DiffElement binding, Object value) {
+        this.binding = binding;
+        this.value = value;
+    }
+
+    public DiffValue(DiffValue parent, Object value) {
+        this(parent.getBinding(), value);
+    }
+
+    public DiffValue(String name, DiffElement parent, Object value) {
+        this.binding = new DiffElement(name, parent, this);
+        this.value = value;
+    }
+
+    public DiffValue(String name, DiffValue parent, Object value) {
+        this(name, parent.getBinding(), value);
+    }
+
+    public DiffElement getBinding() {
+        return binding;
+    }
+
+    protected void setBinding(DiffElement binding) {
+        this.binding = binding;
+    }
+
+    public Object getValue() {
+        return value;
+    }
+
+    public String toString() {
+        return getValue().toString();
+    }
+
+    public String toString(int offset) {
+        return toString();
+    }
+
+    public String toOneLineString() {
+        return getValue().toString();
+    }
+
+    public boolean isAtomic() { return true; }
+    public boolean isCompound() { return ! isAtomic(); }
+}
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffableReader.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffableReader.java
new file mode 100644
index 000000000..84c2eed10
--- /dev/null
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/DiffableReader.java
@@ -0,0 +1,50 @@
+/*
+ * Copyright (c) 2011, The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR
+ * OTHER DEALINGS IN THE SOFTWARE.
+ */
+
+package org.broadinstitute.sting.gatk.walkers.diffengine;
+
+import com.google.java.contract.Ensures;
+import com.google.java.contract.Requires;
+
+import java.io.File;
+
+/**
+ * Created by IntelliJ IDEA.
+ * User: depristo
+ * Date: 7/4/11
+ * Time: 1:09 PM
+ *
+ * Interface for readers creating diffable objects from a file
+ */
+public interface DiffableReader {
+    @Ensures("result != null")
+    public String getName();
+
+    @Ensures("result != null")
+    @Requires("file != null")
+    public DiffElement readFromFile(File file);
+
+    @Requires("file != null")
+    public boolean canRead(File file);
+}
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/Difference.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/Difference.java
new file mode 100644
index 000000000..6627a4cc5
--- /dev/null
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/Difference.java
@@ -0,0 +1,58 @@
+/*
+ * Copyright (c) 2011, The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR
+ * OTHER DEALINGS IN THE SOFTWARE.
+ */
+
+package org.broadinstitute.sting.gatk.walkers.diffengine;
+
+/**
+ * Created by IntelliJ IDEA.
+ * User: depristo
+ * Date: 7/4/11
+ * Time: 12:53 PM
+ *
+ * Represents a specific difference between two specific DiffElements
+ */
+public class Difference {
+    DiffElement master, test;
+
+    public Difference(DiffElement master, DiffElement test) {
+        if ( master == null && test == null ) throw new IllegalArgumentException("Master and test both cannot be null");
+        this.master = master;
+        this.test = test;
+    }
+
+    public String toString() {
+        return String.format("%s:%s!=%s",
+                getFullyQualifiedName(),
+                getOneLineString(master),
+                getOneLineString(test));
+    }
+
+    public String getFullyQualifiedName() {
+        return (master == null ? test : master).fullyQualifiedName();
+    }
+
+    private static String getOneLineString(DiffElement elt) {
+        return elt == null ? "MISSING" : elt.getValue().toOneLineString();
+    }
+}
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/VCFDiffableReader.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/VCFDiffableReader.java
new file mode 100644
index 000000000..743178538
--- /dev/null
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/diffengine/VCFDiffableReader.java
@@ -0,0 +1,119 @@
+/*
+ * Copyright (c) 2011, The Broad Institute
+ *
+ * Permission is hereby granted, free of charge, to any person
+ * obtaining a copy of this software and associated documentation
+ * files (the "Software"), to deal in the Software without
+ * restriction, including without limitation the rights to use,
+ * copy, modify, merge, publish, distribute, sublicense, and/or sell
+ * copies of the Software, and to permit persons to whom the
+ * Software is furnished to do so, subject to the following
+ * conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
+ * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
+ * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
+ * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
+ * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR
+ * OTHER DEALINGS IN THE SOFTWARE.
+ */
+
+package org.broadinstitute.sting.gatk.walkers.diffengine;
+
+import org.broad.tribble.readers.AsciiLineReader;
+import org.broad.tribble.readers.LineReader;
+import org.broadinstitute.sting.utils.codecs.vcf.VCFCodec;
+import org.broadinstitute.sting.utils.codecs.vcf.VCFConstants;
+import org.broadinstitute.sting.utils.codecs.vcf.VCFHeader;
+import org.broadinstitute.sting.utils.variantcontext.Genotype;
+import org.broadinstitute.sting.utils.variantcontext.VariantContext;
+
+import java.io.*;
+import java.util.Arrays;
+import java.util.Map;
+import java.util.zip.GZIPInputStream;
+
+
+/**
+ * Created by IntelliJ IDEA.
+ * User: depristo
+ * Date: 7/4/11
+ * Time: 1:09 PM
+ *
+ * Class implementing diffnode reader for VCF
+ */
+public class VCFDiffableReader implements DiffableReader {
+    @Override
+    public String getName() { return "VCF"; }
+
+    @Override
+    public DiffElement readFromFile(File file) {
+        DiffNode root = DiffNode.rooted(file.getName());
+        try {
+            LineReader lineReader = new AsciiLineReader(new FileInputStream(file));
+            VCFCodec vcfCodec = new VCFCodec();
+            VCFHeader header = (VCFHeader)vcfCodec.readHeader(lineReader);
+
+            String line = lineReader.readLine();
+            while ( line != null ) {
+                VariantContext vc = (VariantContext)vcfCodec.decode(line);
+                String name = vc.getChr() + ":" + vc.getStart();
+                DiffNode vcRoot = DiffNode.empty(name, root);
+
+                // add fields
+                vcRoot.add("CHROM", vc.getChr());
+                vcRoot.add("POS", vc.getStart());
+                vcRoot.add("ID", vc.hasID() ? vc.getID() : VCFConstants.MISSING_VALUE_v4);
+                vcRoot.add("REF", vc.getReference());
+                vcRoot.add("ALT", vc.getAlternateAlleles());
+                vcRoot.add("QUAL", vc.hasNegLog10PError() ? vc.getNegLog10PError() * 10 : VCFConstants.MISSING_VALUE_v4);
+                vcRoot.add("FILTER", vc.getFilters());
+
+                // add info fields
+                for (Map.Entry<String, Object> attribute : vc.getAttributes().entrySet()) {
+                    if ( ! attribute.getKey().startsWith("_") && ! attribute.getKey().equals(VariantContext.ID_KEY))
+                        vcRoot.add(attribute.getKey(), attribute.getValue());
+                }
+
+                for (Genotype g : vc.getGenotypes().values() ) {
+                    DiffNode gRoot = DiffNode.empty(g.getSampleName(), vcRoot);
+                    gRoot.add("GT", g.getGenotypeString());
+                    gRoot.add("GQ", g.hasNegLog10PError() ? g.getNegLog10PError() * 10 : VCFConstants.MISSING_VALUE_v4 );
+
+                    for (Map.Entry<String, Object> attribute : g.getAttributes().entrySet()) {
+                        if ( ! attribute.getKey().startsWith("_") )
+                            gRoot.add(attribute.getKey(), attribute.getValue());
+                    }
+
+                    vcRoot.add(gRoot);
+                }
+
+                root.add(vcRoot);
+                line = lineReader.readLine();
+            }
+
+            lineReader.close();
+        } catch ( IOException e ) {
+            return null;
+        }
+
+        return root.getBinding();
+    }
+
+    @Override
+    public boolean canRead(File file) {
+        try {
+            final String VCF4_HEADER = "##fileformat=VCFv4";
+            char[] buff = new char[VCF4_HEADER.length()];
+            new FileReader(file).read(buff, 0, VCF4_HEADER.length());
+            String firstLine = new String(buff);
+            return firstLine.startsWith(VCF4_HEADER);
+        } catch ( IOException e ) {
+            return false;
+        }
+    }
+}

From d7d15019dd543decffa2169f074b123633fe5984 Mon Sep 17 00:00:00 2001
From: Eric Banks <ebanks@broadinstitute.org>
Date: Tue, 12 Jul 2011 01:16:21 -0400
Subject: [PATCH 59/59] Adding support for other simple header line types (e.g.
 ALT) and cleaning up the interface a bit.

---
 .../walkers/annotator/ChromosomeCounts.java   |  5 +-
 .../walkers/genotyper/UnifiedGenotyper.java   | 17 +++-
 .../utils/codecs/vcf/StandardVCFWriter.java   |  3 +-
 .../utils/codecs/vcf/VCFAltHeaderLine.java    | 28 +++++++
 .../codecs/vcf/VCFCompoundHeaderLine.java     |  3 +
 .../utils/codecs/vcf/VCFFilterHeaderLine.java | 48 +----------
 .../utils/codecs/vcf/VCFFormatHeaderLine.java |  2 +-
 .../utils/codecs/vcf/VCFSimpleHeaderLine.java | 81 +++++++++++++++++++
 .../sting/utils/codecs/vcf/VCFUtils.java      | 15 ----
 9 files changed, 135 insertions(+), 67 deletions(-)
 create mode 100644 public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFAltHeaderLine.java
 create mode 100644 public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFSimpleHeaderLine.java

diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/ChromosomeCounts.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/ChromosomeCounts.java
index 143722d7c..ed10d2072 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/ChromosomeCounts.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/annotator/ChromosomeCounts.java
@@ -25,6 +25,7 @@
 
 package org.broadinstitute.sting.gatk.walkers.annotator;
 
+import org.broadinstitute.sting.utils.codecs.vcf.VCFHeaderLineCount;
 import org.broadinstitute.sting.utils.variantcontext.VariantContext;
 import org.broadinstitute.sting.utils.codecs.vcf.VCFHeaderLineType;
 import org.broadinstitute.sting.utils.codecs.vcf.VCFInfoHeaderLine;
@@ -41,8 +42,8 @@ import java.util.*;
 public class ChromosomeCounts implements InfoFieldAnnotation, StandardAnnotation {
 
     private String[] keyNames = { VCFConstants.ALLELE_NUMBER_KEY, VCFConstants.ALLELE_COUNT_KEY, VCFConstants.ALLELE_FREQUENCY_KEY };
-    private VCFInfoHeaderLine[] descriptions = { new VCFInfoHeaderLine(VCFConstants.ALLELE_FREQUENCY_KEY, -1, VCFHeaderLineType.Float, "Allele Frequency, for each ALT allele, in the same order as listed"),
-            new VCFInfoHeaderLine(VCFConstants.ALLELE_COUNT_KEY, -1, VCFHeaderLineType.Integer, "Allele count in genotypes, for each ALT allele, in the same order as listed"),
+    private VCFInfoHeaderLine[] descriptions = { new VCFInfoHeaderLine(VCFConstants.ALLELE_FREQUENCY_KEY, VCFHeaderLineCount.UNBOUNDED, VCFHeaderLineType.Float, "Allele Frequency, for each ALT allele, in the same order as listed"),
+            new VCFInfoHeaderLine(VCFConstants.ALLELE_COUNT_KEY, VCFHeaderLineCount.UNBOUNDED, VCFHeaderLineType.Integer, "Allele count in genotypes, for each ALT allele, in the same order as listed"),
             new VCFInfoHeaderLine(VCFConstants.ALLELE_NUMBER_KEY, 1, VCFHeaderLineType.Integer, "Total number of alleles in called genotypes") };
 
     public Map<String, Object> annotate(RefMetaDataTracker tracker, ReferenceContext ref, Map<String, AlignmentContext> stratifiedContexts, VariantContext vc) {
diff --git a/public/java/src/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedGenotyper.java b/public/java/src/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedGenotyper.java
index 7a765c602..fe0084a19 100755
--- a/public/java/src/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedGenotyper.java
+++ b/public/java/src/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedGenotyper.java
@@ -37,7 +37,6 @@ import org.broadinstitute.sting.gatk.datasources.rmd.ReferenceOrderedDataSource;
 import org.broadinstitute.sting.utils.*;
 import org.broadinstitute.sting.utils.baq.BAQ;
 import org.broadinstitute.sting.commandline.*;
-import org.broadinstitute.sting.utils.codecs.vcf.VCFUtils;
 
 import java.util.*;
 import java.io.PrintStream;
@@ -158,7 +157,7 @@ public class UnifiedGenotyper extends LocusWalker<VariantCallContext, UnifiedGen
         }
 
         // FORMAT and INFO fields
-        headerInfo.addAll(VCFUtils.getSupportedHeaderStrings());
+        headerInfo.addAll(getSupportedHeaderStrings());
 
         // FILTER fields
         if ( UAC.STANDARD_CONFIDENCE_FOR_EMITTING < UAC.STANDARD_CONFIDENCE_FOR_CALLING )
@@ -167,6 +166,20 @@ public class UnifiedGenotyper extends LocusWalker<VariantCallContext, UnifiedGen
         return headerInfo;
     }
 
+    /**
+     * return a set of supported format lines; what we currently support for output in the genotype fields of a VCF
+     * @return a set of VCF format lines
+     */
+    private static Set<VCFFormatHeaderLine> getSupportedHeaderStrings() {
+        Set<VCFFormatHeaderLine> result = new HashSet<VCFFormatHeaderLine>();
+        result.add(new VCFFormatHeaderLine(VCFConstants.GENOTYPE_KEY, 1, VCFHeaderLineType.String, "Genotype"));
+        result.add(new VCFFormatHeaderLine(VCFConstants.GENOTYPE_QUALITY_KEY, 1, VCFHeaderLineType.Float, "Genotype Quality"));
+        result.add(new VCFFormatHeaderLine(VCFConstants.DEPTH_KEY, 1, VCFHeaderLineType.Integer, "Read Depth (only filtered reads used for calling)"));
+        result.add(new VCFFormatHeaderLine(VCFConstants.PHRED_GENOTYPE_LIKELIHOODS_KEY, VCFHeaderLineCount.UNBOUNDED, VCFHeaderLineType.Float, "Normalized, Phred-scaled likelihoods for AA,AB,BB genotypes where A=ref and B=alt; if site is not biallelic, number of likelihoods if n*(n+1)/2"));
+
+        return result;
+    }
+
     /**
      * Compute at a given locus.
      *
diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/StandardVCFWriter.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/StandardVCFWriter.java
index 230773310..f4996b487 100755
--- a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/StandardVCFWriter.java
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/StandardVCFWriter.java
@@ -358,9 +358,8 @@ public class StandardVCFWriter implements VCFWriter {
             mWriter.write(key);
 
             if ( !entry.getValue().equals("") ) {
-                int numVals = 1;
                 VCFInfoHeaderLine metaData = mHeader.getInfoHeaderLine(key);
-                if ( metaData != null && (metaData.getCountType() != VCFHeaderLineCount.INTEGER || metaData.getCount() > 0) ) {
+                if ( metaData == null || metaData.getCountType() != VCFHeaderLineCount.INTEGER || metaData.getCount() != 0 ) {
                     mWriter.write("=");
                     mWriter.write(entry.getValue());
                 }
diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFAltHeaderLine.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFAltHeaderLine.java
new file mode 100644
index 000000000..a9de949d8
--- /dev/null
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFAltHeaderLine.java
@@ -0,0 +1,28 @@
+package org.broadinstitute.sting.utils.codecs.vcf;
+
+/**
+ * @author ebanks
+ * A class representing a key=value entry for ALT fields in the VCF header
+ */
+public class VCFAltHeaderLine extends VCFSimpleHeaderLine  {
+
+    /**
+     * create a VCF filter header line
+     *
+     * @param name         the name for this header line
+     * @param description  the description for this header line
+     */
+    public VCFAltHeaderLine(String name, String description) {
+        super(name, description, SupportedHeaderLineType.ALT);
+    }
+
+    /**
+     * create a VCF info header line
+     *
+     * @param line      the header line
+     * @param version   the vcf header version
+     */
+    protected VCFAltHeaderLine(String line, VCFHeaderVersion version) {
+        super(line, version, SupportedHeaderLineType.ALT);
+    }
+}
\ No newline at end of file
diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFCompoundHeaderLine.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFCompoundHeaderLine.java
index 49f9ab184..bb822f2ed 100755
--- a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFCompoundHeaderLine.java
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFCompoundHeaderLine.java
@@ -89,6 +89,7 @@ public abstract class VCFCompoundHeaderLine extends VCFHeaderLine implements VCF
      * @param count        the count for this header line
      * @param type         the type for this header line
      * @param description  the description for this header line
+     * @param lineType     the header line type
      */
     protected VCFCompoundHeaderLine(String name, int count, VCFHeaderLineType type, String description, SupportedHeaderLineType lineType) {
         super(lineType.toString(), "");
@@ -108,6 +109,7 @@ public abstract class VCFCompoundHeaderLine extends VCFHeaderLine implements VCF
      * @param count        the count type for this header line
      * @param type         the type for this header line
      * @param description  the description for this header line
+     * @param lineType     the header line type
      */
     protected VCFCompoundHeaderLine(String name, VCFHeaderLineCount count, VCFHeaderLineType type, String description, SupportedHeaderLineType lineType) {
         super(lineType.toString(), "");
@@ -124,6 +126,7 @@ public abstract class VCFCompoundHeaderLine extends VCFHeaderLine implements VCF
      *
      * @param line   the header line
      * @param version      the VCF header version
+     * @param lineType     the header line type
      *
      */
     protected VCFCompoundHeaderLine(String line, VCFHeaderVersion version, SupportedHeaderLineType lineType) {
diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFFilterHeaderLine.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFFilterHeaderLine.java
index 9176fc16e..418b80074 100755
--- a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFFilterHeaderLine.java
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFFilterHeaderLine.java
@@ -1,19 +1,10 @@
 package org.broadinstitute.sting.utils.codecs.vcf;
 
-import java.util.Arrays;
-import java.util.LinkedHashMap;
-import java.util.Map;
-
-
 /**
  * @author ebanks
  * A class representing a key=value entry for FILTER fields in the VCF header
  */
-public class VCFFilterHeaderLine extends VCFHeaderLine implements VCFNamedHeaderLine  {
-
-    private String name;
-    private String description;
-
+public class VCFFilterHeaderLine extends VCFSimpleHeaderLine  {
 
     /**
      * create a VCF filter header line
@@ -22,12 +13,7 @@ public class VCFFilterHeaderLine extends VCFHeaderLine implements VCFNamedHeader
      * @param description  the description for this header line
      */
     public VCFFilterHeaderLine(String name, String description) {
-        super("FILTER", "");
-        this.name = name;
-        this.description = description;
-
-        if ( name == null || description == null )
-            throw new IllegalArgumentException(String.format("Invalid VCFCompoundHeaderLine: key=%s name=%s desc=%s", super.getKey(), name, description ));
+        super(name, description, SupportedHeaderLineType.FILTER);
     }
 
     /**
@@ -37,34 +23,6 @@ public class VCFFilterHeaderLine extends VCFHeaderLine implements VCFNamedHeader
      * @param version   the vcf header version
      */
     protected VCFFilterHeaderLine(String line, VCFHeaderVersion version) {
-        super("FILTER", "");
-        Map<String,String> mapping = VCFHeaderLineTranslator.parseLine(version,line, Arrays.asList("ID","Description"));
-        name = mapping.get("ID");
-        description = mapping.get("Description");
-        if ( description == null && ALLOW_UNBOUND_DESCRIPTIONS ) // handle the case where there's no description provided 
-            description = UNBOUND_DESCRIPTION;
-    }
-
-    protected String toStringEncoding() {
-        Map<String,Object> map = new LinkedHashMap<String,Object>();
-        map.put("ID", name);
-        map.put("Description", description);
-        return "FILTER=" + VCFHeaderLine.toStringEncoding(map);
-    }
-
-    public boolean equals(Object o) {
-        if ( !(o instanceof VCFFilterHeaderLine) )
-            return false;
-        VCFFilterHeaderLine other = (VCFFilterHeaderLine)o;
-        return name.equals(other.name) &&
-               description.equals(other.description);
-    }
-
-    public String getName() {
-        return name;
-    }
-
-    public String getDescription() {
-        return description;
+        super(line, version, SupportedHeaderLineType.FILTER);
     }
 }
\ No newline at end of file
diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFFormatHeaderLine.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFFormatHeaderLine.java
index f68cb670b..474c8dd14 100755
--- a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFFormatHeaderLine.java
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFFormatHeaderLine.java
@@ -17,7 +17,7 @@ public class VCFFormatHeaderLine extends VCFCompoundHeaderLine {
     }
 
     public VCFFormatHeaderLine(String name, VCFHeaderLineCount count, VCFHeaderLineType type, String description) {
-        super(name, count, type, description, SupportedHeaderLineType.INFO);
+        super(name, count, type, description, SupportedHeaderLineType.FORMAT);
     }
 
     protected VCFFormatHeaderLine(String line, VCFHeaderVersion version) {
diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFSimpleHeaderLine.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFSimpleHeaderLine.java
new file mode 100644
index 000000000..152043f28
--- /dev/null
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFSimpleHeaderLine.java
@@ -0,0 +1,81 @@
+package org.broadinstitute.sting.utils.codecs.vcf;
+
+import java.util.Arrays;
+import java.util.LinkedHashMap;
+import java.util.Map;
+
+
+/**
+ * @author ebanks
+ * A class representing a key=value entry for simple VCF header types
+ */
+public abstract class VCFSimpleHeaderLine extends VCFHeaderLine implements VCFNamedHeaderLine  {
+
+    public enum SupportedHeaderLineType {
+        FILTER, ALT;
+    }
+
+    private String name;
+    private String description;
+
+    // our type of line, i.e. filter, alt, etc
+    private final SupportedHeaderLineType lineType;
+
+
+    /**
+     * create a VCF filter header line
+     *
+     * @param name         the name for this header line
+     * @param description  the description for this header line
+     * @param lineType     the header line type
+     */
+    public VCFSimpleHeaderLine(String name, String description, SupportedHeaderLineType lineType) {
+        super(lineType.toString(), "");
+        this.lineType = lineType;
+        this.name = name;
+        this.description = description;
+
+        if ( name == null || description == null )
+            throw new IllegalArgumentException(String.format("Invalid VCFSimpleHeaderLine: key=%s name=%s desc=%s", super.getKey(), name, description ));
+    }
+
+    /**
+     * create a VCF info header line
+     *
+     * @param line      the header line
+     * @param version   the vcf header version
+     * @param lineType     the header line type
+     */
+    protected VCFSimpleHeaderLine(String line, VCFHeaderVersion version, SupportedHeaderLineType lineType) {
+        super(lineType.toString(), "");
+        this.lineType = lineType;
+        Map<String,String> mapping = VCFHeaderLineTranslator.parseLine(version,line, Arrays.asList("ID","Description"));
+        name = mapping.get("ID");
+        description = mapping.get("Description");
+        if ( description == null && ALLOW_UNBOUND_DESCRIPTIONS ) // handle the case where there's no description provided 
+            description = UNBOUND_DESCRIPTION;
+    }
+
+    protected String toStringEncoding() {
+        Map<String,Object> map = new LinkedHashMap<String,Object>();
+        map.put("ID", name);
+        map.put("Description", description);
+        return lineType.toString() + "=" + VCFHeaderLine.toStringEncoding(map);
+    }
+
+    public boolean equals(Object o) {
+        if ( !(o instanceof VCFSimpleHeaderLine) )
+            return false;
+        VCFSimpleHeaderLine other = (VCFSimpleHeaderLine)o;
+        return name.equals(other.name) &&
+               description.equals(other.description);
+    }
+
+    public String getName() {
+        return name;
+    }
+
+    public String getDescription() {
+        return description;
+    }
+}
\ No newline at end of file
diff --git a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFUtils.java b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFUtils.java
index ecede068e..4037f75b9 100755
--- a/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFUtils.java
+++ b/public/java/src/org/broadinstitute/sting/utils/codecs/vcf/VCFUtils.java
@@ -180,19 +180,4 @@ public class VCFUtils {
 
         return new HashSet<VCFHeaderLine>(map.values());
     }
-
-    /**
-     * return a set of supported format lines; what we currently support for output in the genotype fields of a VCF
-     * @return a set of VCF format lines
-     */
-    public static Set<VCFFormatHeaderLine> getSupportedHeaderStrings() {
-        Set<VCFFormatHeaderLine> result = new HashSet<VCFFormatHeaderLine>();
-        result.add(new VCFFormatHeaderLine(VCFConstants.GENOTYPE_KEY, 1, VCFHeaderLineType.String, "Genotype"));
-        result.add(new VCFFormatHeaderLine(VCFConstants.GENOTYPE_QUALITY_KEY, 1, VCFHeaderLineType.Float, "Genotype Quality"));
-        result.add(new VCFFormatHeaderLine(VCFConstants.DEPTH_KEY, 1, VCFHeaderLineType.Integer, "Read Depth (only filtered reads used for calling)"));
-        result.add(new VCFFormatHeaderLine(VCFConstants.PHRED_GENOTYPE_LIKELIHOODS_KEY, -1, VCFHeaderLineType.Float, "Normalized, Phred-scaled likelihoods for AA,AB,BB genotypes where A=ref and B=alt; if site is not biallelic, number of likelihoods if n*(n+1)/2"));
-
-        return result;
-    }
-    
 }
\ No newline at end of file