diff --git a/public/gatk-tools-public/src/main/java/org/broadinstitute/gatk/tools/walkers/rnaseq/ASEReadCounter.java b/public/gatk-tools-public/src/main/java/org/broadinstitute/gatk/tools/walkers/rnaseq/ASEReadCounter.java index f1f9c55d8..d47170514 100644 --- a/public/gatk-tools-public/src/main/java/org/broadinstitute/gatk/tools/walkers/rnaseq/ASEReadCounter.java +++ b/public/gatk-tools-public/src/main/java/org/broadinstitute/gatk/tools/walkers/rnaseq/ASEReadCounter.java @@ -44,25 +44,38 @@ import java.io.PrintStream; import java.util.List; /** - * Calculated allele counts in specific loci, to allow allele specific expression analysis. + * Calculate allele counts for allele-specific expression analysis * *

- * Calculated allele counts in specific loci after filtering based on mapping quality, base quality, depth of coverage, overlapping paired reads and deletion on the position. - * All thresholds and option can be set as command line arguments. - * The output of this tool is a tab delimited txt file, compatible with Mamba, a downstream tool (http://www.well.ox.ac.uk/~rivas/mamba/). - * A user can use -drf DuplicateRead to allow the tool to count also duplicated reads (a useful option for RNAseq data tools) + * This tool calculates allele counts at a set of given loci after applying filters that are tuned for enabling + * allele-specific expression (ASE) analysis. The filters operate on mapping quality, base quality, depth of coverage, + * overlapping paired reads and deletions overlapping the position. All thresholds and options are controlled by + * command-line arguments. *

* + *

Notes

+ * + *

Caveats

+ * *

Input

- *

- * BAM files (with proper headers) to be analyzed for ASE *

- *

- * a VCF file with specific sites to process - *

+ *