diff --git a/protected/java/src/org/broadinstitute/sting/gatk/walkers/haplotypecaller/HaplotypeCaller.java b/protected/java/src/org/broadinstitute/sting/gatk/walkers/haplotypecaller/HaplotypeCaller.java index 6b7373273..82015d153 100644 --- a/protected/java/src/org/broadinstitute/sting/gatk/walkers/haplotypecaller/HaplotypeCaller.java +++ b/protected/java/src/org/broadinstitute/sting/gatk/walkers/haplotypecaller/HaplotypeCaller.java @@ -335,6 +335,13 @@ public class HaplotypeCaller extends ActiveRegionWalker, In // general advanced arguments to control haplotype caller behavior // ----------------------------------------------------------------------------------------------- + /** + * Users should be aware that this argument can really affect the results of the variant calling and should exercise caution. + * Using a prune factor of 1 (or below) will prevent any pruning from the graph which is generally not ideal; it can make the + * calling much slower and even less accurate (because it can prevent effective merging of "tails" in the graph). Higher values + * tend to make the calling much faster, but also lowers the sensitivity of the results (because it ultimately requires higher + * depth to produce calls). + */ @Advanced @Argument(fullName="minPruning", shortName="minPruning", doc = "The minimum allowed pruning factor in assembly graph. Paths with < X supporting kmers are pruned from the graph", required = false) protected int MIN_PRUNE_FACTOR = 2;