Getting back null values from the tables is perfectly reasonable if those covariates don't appear in your table. Need to handle them gracefully.
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@ -150,6 +150,8 @@ public class BaseRecalibration {
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// the rg key is constant over the whole read, the global deltaQ is too
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final int rgKey = fullReadKeySet[0][0];
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final RecalDatum empiricalQualRG = recalibrationTables.getReadGroupTable().get(rgKey, errorModel.ordinal());
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if( empiricalQualRG != null ) {
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final double epsilon = ( globalQScorePrior > 0.0 && errorModel.equals(EventType.BASE_SUBSTITUTION) ? globalQScorePrior : empiricalQualRG.getEstimatedQReported() );
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for (int offset = 0; offset < readLength; offset++) { // recalibrate all bases in the read
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@ -179,6 +181,7 @@ public class BaseRecalibration {
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quals[offset] = recalibratedQualityScore;
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}
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}
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}
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// finally update the base qualities in the read
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read.setBaseQualities(quals, errorModel);
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