From 50e86cfee979ae7763aee0fc543f05bb653f8205 Mon Sep 17 00:00:00 2001 From: depristo Date: Mon, 18 Apr 2011 19:47:49 +0000 Subject: [PATCH] useful chain files git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@5660 348d0f76-0448-11de-a6fe-93d51630548a --- chainFiles/b37tohg18.chain | 49040 +++++++++++++++++++++++++++++ chainFiles/hg19ToHg18.over.chain | 49040 +++++++++++++++++++++++++++++ chainFiles/makeChains.py | 50 + 3 files changed, 98130 insertions(+) create mode 100644 chainFiles/b37tohg18.chain create mode 100644 chainFiles/hg19ToHg18.over.chain create mode 100644 chainFiles/makeChains.py diff --git a/chainFiles/b37tohg18.chain b/chainFiles/b37tohg18.chain new file mode 100644 index 000000000..37c226490 --- /dev/null +++ b/chainFiles/b37tohg18.chain @@ -0,0 +1,49040 @@ +chain 21270171362 1 249250621 + 10000 249233096 chr1 247249719 + 0 247199719 2 +619 137 0 +166661 50000 50000 +40302 50000 50000 +153649 50000 50000 +1098479 1 1 +47 1 1 +73 117 114 +773 1 1 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b/chainFiles/makeChains.py @@ -0,0 +1,50 @@ +#!/bin/tcsh +import os.path +import sys +from optparse import OptionParser +from itertools import * + +def main(): + global OPTIONS + usage = "usage: %prog [options] mode hg19Tohg18.chain" + parser = OptionParser(usage=usage) + +# parser.add_option("-D", "--delete_while_archiving", dest="reallyDeleteInArchiveMode", +# action='store_true', default=False, +# help="if provided, we'll actually delete records when running in archive mode") + + (OPTIONS, args) = parser.parse_args() + if len(args) != 1: + parser.error("Requires exact 1 chain to analyze") + + hg192hg18 = args[0] + + writeChain(hg192hg18, "b37tohg18.chain", lambda x: hg2b(x, 2)) + writeChain(hg192hg18, "b37tob36.chain", lambda x: hg2b(hg2b(x, 2), 7)) + +HG2BCONTIG = dict() +for c in range(1, 23) + ["X", "Y"]: + HG2BCONTIG["chr" + str(c)] = str(c) +HG2BCONTIG["chrM"] = "MT" + +def hg2b(line, pos): + parts = line.split() + if len(parts) > pos and "chr" in parts[pos]: + if parts[pos] in HG2BCONTIG: + parts[pos] = HG2BCONTIG[parts[pos]] + else: + print 'Skipping ', parts[pos] + return "\t".join(parts) + +def writeChain(inFile, outFile, transform): + out = open(outFile, "w") + for line in open(inFile): + newLine = transform(line) + #print 'newline', newLine + if newLine != None: + out.write(newLine) + out.write("\n") + out.close() + +if __name__ == "__main__": + main()