diff --git a/build.xml b/build.xml
index 4acb2086a..85955d774 100644
--- a/build.xml
+++ b/build.xml
@@ -43,6 +43,9 @@
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@@ -89,7 +89,6 @@
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@@ -1080,7 +1059,7 @@
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diff --git a/ivy.xml b/ivy.xml
index a394aa6d7..115f4062a 100644
--- a/ivy.xml
+++ b/ivy.xml
@@ -12,6 +12,9 @@
+
+
+
diff --git a/public/java/test/org/broadinstitute/sting/BaseTest.java b/public/java/test/org/broadinstitute/sting/BaseTest.java
index 7a749c0a2..63faf1ab9 100755
--- a/public/java/test/org/broadinstitute/sting/BaseTest.java
+++ b/public/java/test/org/broadinstitute/sting/BaseTest.java
@@ -67,6 +67,7 @@ public abstract class BaseTest {
public static final String b36dbSNP129 = dbsnpDataLocation + "dbsnp_129_b36.vcf";
public static final String b37dbSNP129 = dbsnpDataLocation + "dbsnp_129_b37.vcf";
public static final String b37dbSNP132 = dbsnpDataLocation + "dbsnp_132_b37.vcf";
+ public static final String hg18dbSNP132 = dbsnpDataLocation + "dbsnp_132.hg18.vcf";
public static final String hapmapDataLocation = comparisonDataLocation + "Validated/HapMap/3.3/";
public static final String b37hapmapGenotypes = hapmapDataLocation + "genotypes_r27_nr.b37_fwd.vcf";
diff --git a/public/java/test/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedGenotyperIntegrationTest.java b/public/java/test/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedGenotyperIntegrationTest.java
index d11fb7e29..da0c8f81f 100755
--- a/public/java/test/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedGenotyperIntegrationTest.java
+++ b/public/java/test/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedGenotyperIntegrationTest.java
@@ -16,8 +16,8 @@ import java.util.Map;
public class UnifiedGenotyperIntegrationTest extends WalkerTest {
- private final static String baseCommand = "-T UnifiedGenotyper -R " + b36KGReference + " -NO_HEADER -glm BOTH";
- private final static String baseCommandIndels = "-T UnifiedGenotyper -R " + b36KGReference + " -NO_HEADER -glm INDEL";
+ private final static String baseCommand = "-T UnifiedGenotyper -R " + b36KGReference + " -NO_HEADER -glm BOTH --dbsnp " + b36dbSNP129;
+ private final static String baseCommandIndels = "-T UnifiedGenotyper -R " + b36KGReference + " -NO_HEADER -glm INDEL --dbsnp " + b36dbSNP129;
// --------------------------------------------------------------------------------------------------------------
//
@@ -28,7 +28,7 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
public void testMultiSamplePilot1() {
WalkerTest.WalkerTestSpec spec = new WalkerTest.WalkerTestSpec(
baseCommand + " -I " + validationDataLocation + "low_coverage_CEU.chr1.10k-11k.bam -o %s -L 1:10,022,000-10,025,000", 1,
- Arrays.asList("16b0c7b47745abcd1ddaa2e261719530"));
+ Arrays.asList("149e6ad9b3fd23551254a691286a96b3"));
executeTest("test MultiSample Pilot1", spec);
}
@@ -54,12 +54,12 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
public void testWithAllelesPassedIn() {
WalkerTest.WalkerTestSpec spec1 = new WalkerTest.WalkerTestSpec(
baseCommand + " --genotyping_mode GENOTYPE_GIVEN_ALLELES -alleles " + validationDataLocation + "allelesForUG.vcf -I " + validationDataLocation + "pilot2_daughters.chr20.10k-11k.bam -o %s -L 20:10,000,000-10,025,000", 1,
- Arrays.asList("811ddc0bd8322b14f14f58df8c627aa9"));
+ Arrays.asList("8de2602679ffc92388da0b6cb4325ef6"));
executeTest("test MultiSample Pilot2 with alleles passed in", spec1);
WalkerTest.WalkerTestSpec spec2 = new WalkerTest.WalkerTestSpec(
baseCommand + " --output_mode EMIT_ALL_SITES --genotyping_mode GENOTYPE_GIVEN_ALLELES -alleles " + validationDataLocation + "allelesForUG.vcf -I " + validationDataLocation + "pilot2_daughters.chr20.10k-11k.bam -o %s -L 20:10,000,000-10,025,000", 1,
- Arrays.asList("5cf08dd7ac3d218082f7be3915ce0b15"));
+ Arrays.asList("ec43daadfb15b00b41aeb0017a45df0b"));
executeTest("test MultiSample Pilot2 with alleles passed in and emitting all sites", spec2);
}
@@ -67,7 +67,7 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
public void testSingleSamplePilot2() {
WalkerTest.WalkerTestSpec spec = new WalkerTest.WalkerTestSpec(
baseCommand + " -I " + validationDataLocation + "NA12878.1kg.p2.chr1_10mb_11_mb.SLX.bam -o %s -L 1:10,000,000-10,100,000", 1,
- Arrays.asList("75156264696563c2f47620fef9424f7c"));
+ Arrays.asList("82d469145c174486ccc494884852cc58"));
executeTest("test SingleSample Pilot2", spec);
}
@@ -77,7 +77,7 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
//
// --------------------------------------------------------------------------------------------------------------
- private final static String COMPRESSED_OUTPUT_MD5 = "7255e03430549cb97d8fcae34cbffb02";
+ private final static String COMPRESSED_OUTPUT_MD5 = "a5a9f38c645d6004d4640765a8b77ce4";
@Test
public void testCompressedOutput() {
@@ -107,7 +107,7 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
// Note that we need to turn off any randomization for this to work, so no downsampling and no annotations
- String md5 = "7912109e83fda21dae90ef8d5dd0140d";
+ String md5 = "0a45761c0e557d9c2080eb9e7f4f6c41";
WalkerTest.WalkerTestSpec spec1 = new WalkerTest.WalkerTestSpec(
baseCommand + " -dt NONE -G none -I " + validationDataLocation + "NA12878.1kg.p2.chr1_10mb_11_mb.SLX.bam -o %s -L 1:10,000,000-10,075,000", 1,
@@ -138,10 +138,9 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
@Test
public void testCallingParameters() {
HashMap e = new HashMap();
- e.put( "--min_base_quality_score 26", "6d3aa9f783ca63f37c952f83eeda593c" );
- e.put( "--min_mapping_quality_score 26", "51bfdf777123bf49de5d92ffde5c74e7" );
- e.put( "--p_nonref_model GRID_SEARCH", "333328ab2c8da2875fade599e80a271f" );
- e.put( "--computeSLOD", "226caa28a4fa9fe34f3beb8a23f3d53d" );
+ e.put( "--min_base_quality_score 26", "531966aee1cd5dced61c96c4fedb59a9" );
+ e.put( "--min_mapping_quality_score 26", "c71ca370947739cb7d87b59452be7a07" );
+ e.put( "--computeSLOD", "1a5648f26c18ced27df4be031b44e72d" );
for ( Map.Entry entry : e.entrySet() ) {
WalkerTest.WalkerTestSpec spec = new WalkerTest.WalkerTestSpec(
@@ -154,9 +153,9 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
@Test
public void testOutputParameter() {
HashMap e = new HashMap();
- e.put( "-sites_only", "5f659dee408710d3709ed72005cd863a" );
- e.put( "--output_mode EMIT_ALL_CONFIDENT_SITES", "55d09bf13149bddc06cc36be0801507b" );
- e.put( "--output_mode EMIT_ALL_SITES", "727f49dcb2439b18446829efc3b1561c" );
+ e.put( "-sites_only", "d40114aa201aa33ff5f174f15b6b73af" );
+ e.put( "--output_mode EMIT_ALL_CONFIDENT_SITES", "3c681b053fd2280f3c42041d24243752" );
+ e.put( "--output_mode EMIT_ALL_SITES", "eafa6d71c5ecd64dfee5d7a3f60e392e" );
for ( Map.Entry entry : e.entrySet() ) {
WalkerTest.WalkerTestSpec spec = new WalkerTest.WalkerTestSpec(
@@ -170,12 +169,12 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
public void testConfidence() {
WalkerTest.WalkerTestSpec spec1 = new WalkerTest.WalkerTestSpec(
baseCommand + " -I " + validationDataLocation + "NA12878.1kg.p2.chr1_10mb_11_mb.SLX.bam -o %s -L 1:10,000,000-10,010,000 -stand_call_conf 10 ", 1,
- Arrays.asList("51bfdf777123bf49de5d92ffde5c74e7"));
+ Arrays.asList("c71ca370947739cb7d87b59452be7a07"));
executeTest("test confidence 1", spec1);
WalkerTest.WalkerTestSpec spec2 = new WalkerTest.WalkerTestSpec(
baseCommand + " -I " + validationDataLocation + "NA12878.1kg.p2.chr1_10mb_11_mb.SLX.bam -o %s -L 1:10,000,000-10,010,000 -stand_emit_conf 10 ", 1,
- Arrays.asList("c67c285e70fd4457c9f9ce7bd878ddca"));
+ Arrays.asList("1c0a599d475cc7d5e745df6e9b6c0d29"));
executeTest("test confidence 2", spec2);
}
@@ -187,8 +186,8 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
@Test
public void testHeterozyosity() {
HashMap e = new HashMap();
- e.put( 0.01, "7ecc564d4db97d5932cef2e558550ed2" );
- e.put( 1.0 / 1850, "aa9e101bb9f9e111fe292fec467d915a" );
+ e.put( 0.01, "af5199fbc0853cf5888acdcc88f012bc" );
+ e.put( 1.0 / 1850, "4e6938645ccde1fdf204ffbf4e88170f" );
for ( Map.Entry entry : e.entrySet() ) {
WalkerTest.WalkerTestSpec spec = new WalkerTest.WalkerTestSpec(
@@ -212,7 +211,7 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
" -o %s" +
" -L 1:10,000,000-10,100,000",
1,
- Arrays.asList("2efd686186b2c5129be4cf89274a24dd"));
+ Arrays.asList("213ebaaaacf850312d885e918eb33500"));
executeTest(String.format("test multiple technologies"), spec);
}
@@ -231,7 +230,7 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
" -L 1:10,000,000-10,100,000" +
" -baq CALCULATE_AS_NECESSARY",
1,
- Arrays.asList("2892d35331fe9fc141ba19269ec7caed"));
+ Arrays.asList("3aecba34a89f3525afa57a38dc20e6cd"));
executeTest(String.format("test calling with BAQ"), spec);
}
@@ -250,7 +249,7 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
" -o %s" +
" -L 1:10,000,000-10,500,000",
1,
- Arrays.asList("8c2afb4289ed44521933d1a74c8d6c7f"));
+ Arrays.asList("043973c719a85de29a35a33a674616fb"));
executeTest(String.format("test indel caller in SLX"), spec);
}
@@ -265,7 +264,7 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
" -minIndelCnt 1" +
" -L 1:10,000,000-10,100,000",
1,
- Arrays.asList("b6fb70590a10e1c27fb611732916f27d"));
+ Arrays.asList("68d4e6c1849e892467aed61c33e7bf24"));
executeTest(String.format("test indel caller in SLX witn low min allele count"), spec);
}
@@ -278,7 +277,7 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
" -o %s" +
" -L 1:10,000,000-10,500,000",
1,
- Arrays.asList("61642502bd08cc03cdaaeb83a5426b46"));
+ Arrays.asList("f86d453c5d2d2f33fb28ae2050658a5e"));
executeTest(String.format("test indel calling, multiple technologies"), spec);
}
@@ -288,14 +287,14 @@ public class UnifiedGenotyperIntegrationTest extends WalkerTest {
WalkerTest.WalkerTestSpec spec1 = new WalkerTest.WalkerTestSpec(
baseCommandIndels + " --genotyping_mode GENOTYPE_GIVEN_ALLELES -alleles " + validationDataLocation + "indelAllelesForUG.vcf -I " + validationDataLocation +
"pilot2_daughters.chr20.10k-11k.bam -o %s -L 20:10,000,000-10,100,000", 1,
- Arrays.asList("69b0b3f089c80b9864294d838a061336"));
+ Arrays.asList("408d3aba4d094c067fc00a43992c2292"));
executeTest("test MultiSample Pilot2 indels with alleles passed in", spec1);
WalkerTest.WalkerTestSpec spec2 = new WalkerTest.WalkerTestSpec(
baseCommandIndels + " --output_mode EMIT_ALL_SITES --genotyping_mode GENOTYPE_GIVEN_ALLELES -alleles "
+ validationDataLocation + "indelAllelesForUG.vcf -I " + validationDataLocation +
"pilot2_daughters.chr20.10k-11k.bam -o %s -L 20:10,000,000-10,100,000", 1,
- Arrays.asList("c90174cfd7dd68bdef36fe2c60145e10"));
+ Arrays.asList("94977d6e42e764280e9deaf4e3ac8c80"));
executeTest("test MultiSample Pilot2 indels with alleles passed in and emitting all sites", spec2);
}
diff --git a/public/java/test/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedGenotyperPerformanceTest.java b/public/java/test/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedGenotyperPerformanceTest.java
index fb7e84d22..3ff453dab 100755
--- a/public/java/test/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedGenotyperPerformanceTest.java
+++ b/public/java/test/org/broadinstitute/sting/gatk/walkers/genotyper/UnifiedGenotyperPerformanceTest.java
@@ -15,7 +15,7 @@ public class UnifiedGenotyperPerformanceTest extends WalkerTest {
" -glm BOTH" +
" -I " + evaluationDataLocation + "NA12878.GAII.chr1.50MB.bam" +
" -L chr1:1-50,000,000" +
- " --dbsnp:VCF " + b36dbSNP129 +
+ " --dbsnp:VCF " + hg18dbSNP132 +
" -o /dev/null",
0,
new ArrayList(0));
@@ -30,7 +30,7 @@ public class UnifiedGenotyperPerformanceTest extends WalkerTest {
" -glm BOTH" +
" -I " + evaluationDataLocation + "NA12878.ESP.WEx.chr1.bam" +
" -L " + evaluationDataLocation + "whole_exome_agilent_designed_120.targets.chr1.interval_list" +
- " --dbsnp:vcf " + b36dbSNP129 +
+ " --dbsnp:vcf " + hg18dbSNP132 +
" -o /dev/null",
0,
new ArrayList(0));
@@ -46,7 +46,7 @@ public class UnifiedGenotyperPerformanceTest extends WalkerTest {
" -glm BOTH" +
" -L chr1:1-50,000,000" +
" -nt 10" +
- " --dbsnp:vcf " + b36dbSNP129 +
+ " --dbsnp:vcf " + hg18dbSNP132 +
" -o /dev/null",
0,
new ArrayList(0));
diff --git a/public/java/test/org/broadinstitute/sting/gatk/walkers/recalibration/RecalibrationWalkersPerformanceTest.java b/public/java/test/org/broadinstitute/sting/gatk/walkers/recalibration/RecalibrationWalkersPerformanceTest.java
index 43ea401f7..bccb95795 100755
--- a/public/java/test/org/broadinstitute/sting/gatk/walkers/recalibration/RecalibrationWalkersPerformanceTest.java
+++ b/public/java/test/org/broadinstitute/sting/gatk/walkers/recalibration/RecalibrationWalkersPerformanceTest.java
@@ -16,7 +16,7 @@ public class RecalibrationWalkersPerformanceTest extends WalkerTest {
" -L chr1:1-50,000,000" +
" -standard" +
" -OQ" +
- " -B:dbsnp,VCF " + GATKDataLocation + "dbsnp_132.hg18.vcf" +
+ " -knownSites " + GATKDataLocation + "dbsnp_132.hg18.vcf" +
" -recalFile /dev/null" + moreArgs,
0,
new ArrayList(0));
@@ -31,7 +31,7 @@ public class RecalibrationWalkersPerformanceTest extends WalkerTest {
" -L " + evaluationDataLocation + "whole_exome_agilent_designed_120.targets.chr1.interval_list" +
" -standard" +
" -OQ" +
- " -B:dbsnp,VCF " + GATKDataLocation + "dbsnp_132.hg18.vcf" +
+ " -knownSites " + GATKDataLocation + "dbsnp_132.hg18.vcf" +
" -recalFile /dev/null" + moreArgs,
0,
new ArrayList(0));
diff --git a/settings/repository/org.broad/tribble-16.xml b/settings/repository/org.broad/tribble-16.xml
deleted file mode 100644
index e23eec339..000000000
--- a/settings/repository/org.broad/tribble-16.xml
+++ /dev/null
@@ -1,4 +0,0 @@
-
-
-
diff --git a/settings/repository/org.broad/tribble-16.jar b/settings/repository/org.broad/tribble-18.jar
similarity index 87%
rename from settings/repository/org.broad/tribble-16.jar
rename to settings/repository/org.broad/tribble-18.jar
index 331f28ec3..1ea101dd0 100644
Binary files a/settings/repository/org.broad/tribble-16.jar and b/settings/repository/org.broad/tribble-18.jar differ
diff --git a/settings/repository/org.broad/tribble-18.xml b/settings/repository/org.broad/tribble-18.xml
new file mode 100644
index 000000000..d2648ddad
--- /dev/null
+++ b/settings/repository/org.broad/tribble-18.xml
@@ -0,0 +1,3 @@
+
+
+