Minor reformating for pooled calling
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@2063 348d0f76-0448-11de-a6fe-93d51630548a
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@ -18,6 +18,10 @@ public class DiploidGenotypeCalculationModel extends JointEstimateGenotypeCalcul
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return splitContextBySample(context);
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return splitContextBySample(context);
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}
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}
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protected int getNSamples(HashMap<String, AlignmentContextBySample> contexts) {
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return contexts.size();
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}
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protected void initializeLikelihoods(char ref, HashMap<String, AlignmentContextBySample> contexts, StratifiedContext contextType) {
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protected void initializeLikelihoods(char ref, HashMap<String, AlignmentContextBySample> contexts, StratifiedContext contextType) {
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GLs.clear();
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GLs.clear();
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@ -36,7 +36,7 @@ public abstract class JointEstimateGenotypeCalculationModel extends GenotypeCalc
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protected abstract void initializeLikelihoods(char ref, HashMap<String, AlignmentContextBySample> contexts, StratifiedContext contextType);
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protected abstract void initializeLikelihoods(char ref, HashMap<String, AlignmentContextBySample> contexts, StratifiedContext contextType);
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protected abstract double computeLog10PofDgivenAFi(DiploidGenotype refGenotype, DiploidGenotype hetGenotype, DiploidGenotype homGenotype, double f);
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protected abstract double computeLog10PofDgivenAFi(DiploidGenotype refGenotype, DiploidGenotype hetGenotype, DiploidGenotype homGenotype, double f);
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protected abstract List<Genotype> makeGenotypeCalls(char ref, HashMap<String, AlignmentContextBySample> contexts, GenomeLoc loc);
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protected abstract List<Genotype> makeGenotypeCalls(char ref, HashMap<String, AlignmentContextBySample> contexts, GenomeLoc loc);
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protected abstract int getNSamples(HashMap<String, AlignmentContextBySample> contexts);
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public Pair<List<Genotype>, GenotypeLocusData> calculateGenotype(RefMetaDataTracker tracker, char ref, AlignmentContext context, DiploidGenotypePriors priors) {
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public Pair<List<Genotype>, GenotypeLocusData> calculateGenotype(RefMetaDataTracker tracker, char ref, AlignmentContext context, DiploidGenotypePriors priors) {
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@ -45,7 +45,7 @@ public abstract class JointEstimateGenotypeCalculationModel extends GenotypeCalc
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if ( contexts == null )
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if ( contexts == null )
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return null;
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return null;
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int numSamples = contexts.size();
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int numSamples = getNSamples(contexts);
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int frequencyEstimationPoints = (2 * numSamples) + 1; // (add 1 for allele frequency of zero)
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int frequencyEstimationPoints = (2 * numSamples) + 1; // (add 1 for allele frequency of zero)
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initializeAlleleFrequencies(frequencyEstimationPoints);
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initializeAlleleFrequencies(frequencyEstimationPoints);
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@ -10,9 +10,13 @@ import net.sf.samtools.SAMRecord;
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public class PooledCalculationModel extends JointEstimateGenotypeCalculationModel {
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public class PooledCalculationModel extends JointEstimateGenotypeCalculationModel {
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protected PooledCalculationModel() {}
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protected PooledCalculationModel() {
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}
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protected int getNSamples(HashMap<String, AlignmentContextBySample> contexts) {
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return POOL_SIZE;
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}
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protected HashMap<String, AlignmentContextBySample> createContexts(AlignmentContext context) {
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protected HashMap<String, AlignmentContextBySample> createContexts(AlignmentContext context) {
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// for testing purposes, we may want to throw multi-samples at pooled mode,
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// for testing purposes, we may want to throw multi-samples at pooled mode,
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// so we can't use the standard splitContextBySample() method here
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// so we can't use the standard splitContextBySample() method here
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@ -48,10 +52,10 @@ public class PooledCalculationModel extends JointEstimateGenotypeCalculationMode
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}
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}
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protected double computeLog10PofDgivenAFi(DiploidGenotype refGenotype, DiploidGenotype hetGenotype, DiploidGenotype homGenotype, double f) {
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protected double computeLog10PofDgivenAFi(DiploidGenotype refGenotype, DiploidGenotype hetGenotype, DiploidGenotype homGenotype, double f) {
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System.out.printf("%s %.2f%n", hetGenotype, f);
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// TODO -- IMPLEMENT ME
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// TODO -- IMPLEMENT ME
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return 0.0;
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return -100.0;
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}
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}
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protected List<Genotype> makeGenotypeCalls(char ref, HashMap<String, AlignmentContextBySample> contexts, GenomeLoc loc) {
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protected List<Genotype> makeGenotypeCalls(char ref, HashMap<String, AlignmentContextBySample> contexts, GenomeLoc loc) {
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@ -77,7 +77,7 @@ public class UnifiedArgumentCollection {
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@Argument(fullName = "max_deletions", shortName = "deletions", doc = "Maximum reads with deletions spanning this locus for it to be callable [to disable, set to < 0; default:1]", required = false)
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@Argument(fullName = "max_deletions", shortName = "deletions", doc = "Maximum reads with deletions spanning this locus for it to be callable [to disable, set to < 0; default:1]", required = false)
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public Integer MAX_DELETIONS = 1;
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public Integer MAX_DELETIONS = 1;
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@Argument(fullName = "max_coverage", shortName = "coverage", doc = "Maximum reads at this locus for it to be callable; to disable, provide value < 1 [default:10,000]", required = false)
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@Argument(fullName = "max_coverage", shortName = "mc", doc = "Maximum reads at this locus for it to be callable; to disable, provide value < 1 [default:10,000]", required = false)
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public Integer MAX_READS_IN_PILEUP = 10000;
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public Integer MAX_READS_IN_PILEUP = 10000;
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@Argument(fullName = "min_allele_frequency", shortName = "min_freq", doc = "The minimum possible allele frequency in a population (advanced)", required = false)
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@Argument(fullName = "min_allele_frequency", shortName = "min_freq", doc = "The minimum possible allele frequency in a population (advanced)", required = false)
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