I said - delete!
git-svn-id: file:///humgen/gsa-scr1/gsa-engineering/svn_contents/trunk@259 348d0f76-0448-11de-a6fe-93d51630548a
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package org.broadinstitute.sting.playground.gatk.refdata;
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import org.broadinstitute.sting.gatk.refdata.ReferenceOrderedDatum;
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import org.broadinstitute.sting.utils.GenomeLoc;
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import java.util.List;
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/**
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* Created by IntelliJ IDEA.
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* User: asivache
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* Date: Apr 1, 2009
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* Time: 11:02:03 AM
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* To change this template use File | Settings | File Templates.
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*/
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public interface AllelicVariant extends Comparable<ReferenceOrderedDatum> {
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// ----------------------------------------------------------------------
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//
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// manipulating the SNP information
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//
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// ----------------------------------------------------------------------
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/** Location of this variant on the reference (on the forward strand).
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*
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* @return
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*/
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GenomeLoc getLocation();
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/** Returns bases in the reference allele as a String. String can be empty (as in insertion into
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* the reference), can contain a single character (as in SNP or one-base deletion), or multiple characters
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* (for longer indels).
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*
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* @return reference allele, forward strand
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*/
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String getRefBasesFWD();
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/** Returns reference (major) allele base for a SNP variant as a character; should throw IllegalStateException
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* if variant is not a SNP.
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*
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* @return reference base on the forward strand
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*/
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char getRefSnpFWD() throws IllegalStateException;
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/** Returns bases in the alternative allele as a String. String can be empty (as in deletion from
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* the reference), can contain a single character (as in SNP or one-base insertion), or multiple characters
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* (for longer indels).
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*
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* @return alternative allele, forward strand
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*/
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String getAltBasesFWD();
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/** Returns alternative (minor) allele base for a SNP variant as a character; should throw IllegalStateException
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* if variant is not a SNP.
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*
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* @return alternative allele base on the forward starnd
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*/
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char getAltSnpFWD() throws IllegalStateException;
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/** Is this variant a SNP?
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*
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* @return true or false
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*/
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boolean isSNP();
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/** Is this variant an insertion? The contract requires isIndel() to return true
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* if this method returns true.
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*
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* @return true or false
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*/
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boolean isInsertion();
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/** Is this variant a deletion? The contract requires isIndel() to return true
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* if isDeletion() returns true.
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*
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* @return true or false
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*/
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boolean isDeletion();
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/** Is this variant an insertion or a deletion? The contract requires
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* this to be true if either isInsertion() or isDeletion() returns true. However,
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* this method is currently allowed to return true even if neither of isInsertion()
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* and isDeletion() does.
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* @return
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*/
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boolean isIndel();
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/** Returns minor allele frequency.
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*
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* @return
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*/
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double getMAF() ;
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/** Is this variant an actual genotype (such as individual call from sequencing, HapMap chip etc), or
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* population allelic variant (call from pooled sequencing, dbSNP site etc). Only if variant is a genotype, there
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* is a meaningful question of, e.g., whether it is a het, or homogeneous non-ref.
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*
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* @return true if this variant is an actual genotype.
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*/
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boolean isGenotype();
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/** Returns phred-mapped confidence in variation event (e.g. MAQ's SNP confidence, or AlleleCaller's best vs. ref).
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*
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* @return
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*/
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double getVariationConfidence();
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/** Returns phred-mapped confidence in called genotype (e.g. MAQ's consensus confidence, or AlleleCaller's
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* best vs next-best.
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* @return
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*/
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double getConsensusConfidence();
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/** Returns actual observed genotype. Allowed to return more than two alleles (@see #getPloidy()). If this variant
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* is not a genotype, should throw an IllegalStateException.
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* @return
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*/
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List<String> getGenotype() throws IllegalStateException;
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/** Return actual number of observed alleles (chromosomes) in the genotype. If this variant is not a genotype,
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* should throw IllegalStateException.
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* @return
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*/
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int getPloidy() throws IllegalStateException;
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}
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