6 lines
878 B
Markdown
6 lines
878 B
Markdown
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## Bait bias
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http://gatkforums.broadinstitute.org/gatk/discussion/6333/bait-bias
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<p>Bait bias (single bait bias or reference bias artifact) is a type of artifact that affects data generated through <a href="http://gatkforums.broadinstitute.org/gatk/discussion/6331">hybrid selection</a> methods. </p>
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<p>These artifacts occur during or after the target selection step, and correlate with substitution rates that are biased or higher for sites having one base on the reference/positive strand relative to sites having the complementary base on that strand. For example, a G>T artifact during the target selection step might result in a higher (G>T)/(C>A) substitution rate at sites with a G on the positive strand (and C on the negative), relative to sites with the flip (C positive)/(G negative). This is known as the <strong>"G-Ref"</strong> artifact.</p>
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