#include #include #include #include #include #include #include #include "utils.h" #include "ksw.h" // static const kswr_t g_defr = { 0, -1, -1, -1, -1, -1, -1 }; typedef struct _kswq_t { int qlen, slen; uint8_t shift, mdiff, max, size; __m256i *qp, *H0, *H1, *E, *Hmax; } kswq_t; /** * Initialize the query data structure * * @param size Number of bytes used to store a score; valid valures are 1 or 2 * @param qlen Length of the query sequence * @param query Query sequence * @param m Size of the alphabet (ACGTN) * @param mat Scoring matrix in a one-dimension array * * @return Query data structure */ kswq_t *ksw_qinit_avx2(int size, int qlen, const uint8_t *query, int m, const int8_t *mat) { kswq_t *q; int slen, a, tmp, p; size = size > 1 ? 2 : 1; p = 16 * (3 - size); // # values per __m256i slen = (qlen + p - 1) / p; // segmented length q = (kswq_t *)malloc(sizeof(kswq_t) + 512 + 32 * slen * (m + 4)); // a single block of memory q->qp = (__m256i *)(((size_t)q + sizeof(kswq_t) + 31) >> 5 << 5); // align memory q->H0 = q->qp + slen * m; q->H1 = q->H0 + slen; q->E = q->H1 + slen; q->Hmax = q->E + slen; q->slen = slen; q->qlen = qlen; q->size = size; // compute shift tmp = m * m; for (a = 0, q->shift = 127, q->mdiff = 0; a < tmp; ++a) { // find the minimum and maximum score if (mat[a] < (int8_t)q->shift) q->shift = mat[a]; if (mat[a] > (int8_t)q->mdiff) q->mdiff = mat[a]; } q->max = q->mdiff; q->shift = 256 - q->shift; // NB: q->shift is uint8_t q->mdiff += q->shift; // this is the difference between the min and max scores // An example: p=8, qlen=19, slen=3 and segmentation: // {{0,3,6,9,12,15,18,-1},{1,4,7,10,13,16,-1,-1},{2,5,8,11,14,17,-1,-1}} if (size == 1) { int8_t *t = (int8_t*)q->qp; for (a = 0; a < m; ++a) { int i, k, nlen = slen * p; const int8_t *ma = mat + a * m; for (i = 0; i < slen; ++i) for (k = i; k < nlen; k += slen) // p iterations *t++ = (k >= qlen? 0 : ma[query[k]]) + q->shift; } } else { int16_t *t = (int16_t*)q->qp; for (a = 0; a < m; ++a) { int i, k, nlen = slen * p; const int8_t *ma = mat + a * m; for (i = 0; i < slen; ++i) for (k = i; k < nlen; k += slen) // p iterations *t++ = (k >= qlen? 0 : ma[query[k]]); } } return q; }