r845: updated NEWS
I will use the new version for a while and then release it.
This commit is contained in:
parent
92bc6849a3
commit
a458442b24
41
NEWS.md
41
NEWS.md
|
|
@ -1,3 +1,44 @@
|
||||||
|
Release 0.7.11 (16 September, 2014)
|
||||||
|
-----------------------------------
|
||||||
|
|
||||||
|
A major change to BWA-MEM is the support of mapping to ALT contigs. To use this
|
||||||
|
feature, users need to manually create a file "<index>.alt" with each line
|
||||||
|
giving the name of an ALT contig. In mapping, BWA-MEM considers all chromosomes
|
||||||
|
and contigs equally when it finds seeds, constructs chains, extends seeds and
|
||||||
|
derives the final alignments. It also uses all hits for the estimation of
|
||||||
|
mapping quality of ALT hits. However, BWA-MEM ignores ALT hits when it
|
||||||
|
estimates the mapping quality of hits to the primary assembly. As a result,
|
||||||
|
having ALT contigs almost has not effect on alignments to the primary assembly
|
||||||
|
(seeding may be affected in rare corner cases). At the same time, users may
|
||||||
|
get a primary alignment to ALT contigs (no 0x800 flag) if there are no good
|
||||||
|
hits to the primary assembly, or get a supplementary alignment to ALT contigs
|
||||||
|
if it is better than hits to the primary assembly. Since this release, it is
|
||||||
|
recommended to include ALT contigs.
|
||||||
|
|
||||||
|
Users may consider to use ALT contigs from GRCh38. I am also constructing a
|
||||||
|
non-redundant and more complete set of sequences missing from GRCh38.
|
||||||
|
|
||||||
|
Other notable changes to BWA-MEM:
|
||||||
|
|
||||||
|
* Added option `-b` to `bwa index`. This option tunes the batch size used in
|
||||||
|
the construction of BWT. It is advised to use large `-b` for huge reference
|
||||||
|
sequences such as the *nt* database.
|
||||||
|
|
||||||
|
* Optimized for PacBio data. This includes a change to the scoring based on a
|
||||||
|
mini-study done by Aaron Quinlan and a heuristic speedup. Further speedup is
|
||||||
|
possible, but needs more careful investigation.
|
||||||
|
|
||||||
|
* Dropped PacBio read-to-read alignment for now. BWA-MEM is only good at
|
||||||
|
finding the best hit, not all hits. Option `-x pbread` is still available,
|
||||||
|
but not shown on the command line.
|
||||||
|
|
||||||
|
* Added new pre-setting for Oxford Nanopore 2D reads. For small genomes,
|
||||||
|
though, LAST is still more sensitive.
|
||||||
|
|
||||||
|
(0.7.11: 16 September 2014, r845)
|
||||||
|
|
||||||
|
|
||||||
|
|
||||||
Release 0.7.10 (13 July, 2014)
|
Release 0.7.10 (13 July, 2014)
|
||||||
------------------------------
|
------------------------------
|
||||||
|
|
||||||
|
|
|
||||||
2
main.c
2
main.c
|
|
@ -4,7 +4,7 @@
|
||||||
#include "utils.h"
|
#include "utils.h"
|
||||||
|
|
||||||
#ifndef PACKAGE_VERSION
|
#ifndef PACKAGE_VERSION
|
||||||
#define PACKAGE_VERSION "0.7.10-r844-dirty"
|
#define PACKAGE_VERSION "0.7.10-r845-dirty"
|
||||||
#endif
|
#endif
|
||||||
|
|
||||||
int bwa_fa2pac(int argc, char *argv[]);
|
int bwa_fa2pac(int argc, char *argv[]);
|
||||||
|
|
|
||||||
Loading…
Reference in New Issue