r845: updated NEWS
I will use the new version for a while and then release it.
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NEWS.md
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NEWS.md
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Release 0.7.11 (16 September, 2014)
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-----------------------------------
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A major change to BWA-MEM is the support of mapping to ALT contigs. To use this
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feature, users need to manually create a file "<index>.alt" with each line
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giving the name of an ALT contig. In mapping, BWA-MEM considers all chromosomes
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and contigs equally when it finds seeds, constructs chains, extends seeds and
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derives the final alignments. It also uses all hits for the estimation of
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mapping quality of ALT hits. However, BWA-MEM ignores ALT hits when it
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estimates the mapping quality of hits to the primary assembly. As a result,
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having ALT contigs almost has not effect on alignments to the primary assembly
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(seeding may be affected in rare corner cases). At the same time, users may
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get a primary alignment to ALT contigs (no 0x800 flag) if there are no good
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hits to the primary assembly, or get a supplementary alignment to ALT contigs
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if it is better than hits to the primary assembly. Since this release, it is
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recommended to include ALT contigs.
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Users may consider to use ALT contigs from GRCh38. I am also constructing a
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non-redundant and more complete set of sequences missing from GRCh38.
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Other notable changes to BWA-MEM:
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* Added option `-b` to `bwa index`. This option tunes the batch size used in
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the construction of BWT. It is advised to use large `-b` for huge reference
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sequences such as the *nt* database.
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* Optimized for PacBio data. This includes a change to the scoring based on a
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mini-study done by Aaron Quinlan and a heuristic speedup. Further speedup is
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possible, but needs more careful investigation.
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* Dropped PacBio read-to-read alignment for now. BWA-MEM is only good at
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finding the best hit, not all hits. Option `-x pbread` is still available,
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but not shown on the command line.
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* Added new pre-setting for Oxford Nanopore 2D reads. For small genomes,
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though, LAST is still more sensitive.
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(0.7.11: 16 September 2014, r845)
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Release 0.7.10 (13 July, 2014)
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------------------------------
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