Release BWA-0.6.0
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NEWS
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NEWS
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Release 0.5.10 and 0.6.0 (12 November, 2011)
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~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
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The 0.6.0 release comes with two major changes. Firstly, the index data
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structure has been changed to support genomes longer than 4GB. The forward and
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reverse backward genome is now integrated in one index. This change speeds up
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BWA-short by about 20% and BWA-SW by 90% with the mapping acccuracy largely
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unchanged. A tradeoff is BWA requires more memory, but this is the price almost
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all mappers that index the genome have to pay.
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Secondly, BWA-SW in 0.6.0 now works with paired-end data. It is more accurate
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for highly unique reads and more robust to long indels and structural
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variations. However, BWA-short still has edges for reads with many suboptimal
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hits. It is yet to know which algorithm is the best for variant calling.
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0.5.10 is a bugfix release only and is likely to be the last release in the 0.5
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branch unless I find critical bugs in future.
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Other notable changes:
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* Added the `fastmap' command that finds super-maximal exact matches. It does
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not give the final alignment, but runs much faster. It can be a building
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block for other alignment algorithms. [0.6.0 only]
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* Output the timing information before BWA exits. This also tells users that
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the task has been finished instead of being killed or aborted. [0.6.0 only]
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* Sped up multi-threading when using many (>20) CPU cores.
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* Check I/O error.
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* Increased the maximum barcode length to 63bp.
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* Automatically choose the indexing algorithm.
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* Bugfix: very rare segfault due to an uninitialized variable. The bug also
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affects the placement of suboptimal alignments. The effect is very minor.
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This release involves quite a lot of tricky changes. Although it has been
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tested on a few data sets, subtle bugs may be still hidden. It is *NOT*
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recommended to use this release in a production pipeline. In future, however,
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BWA-SW may be better when reads continue to go longer. I would encourage users
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to try the 0.6 release. I would also like to hear the users' experience. Thank
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you.
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(0.6.0: 12 November 2011, r85)
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Beta Release 0.5.9 (24 January, 2011)
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~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
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