diff --git a/README-alt.md b/README-alt.md index 14c5d58..6476c63 100644 --- a/README-alt.md +++ b/README-alt.md @@ -158,7 +158,8 @@ depth, clustered variants or weak alignment. We believe most hs38-only calls are problematic. In addition, if we compare two NA12878 replicates from HiSeq X10 with nearly identical library construction, the difference is ~140k, an order of magnitude higher than the difference between hs38 and hs38d6. ALT contigs, -decoy and HLA genes in hs38d6 improve variant calling at little cost. +decoy and HLA genes in hs38d6 improve variant calling and enable the analyses of +ALT contigs and HLA typing at little cost. ## Problems and Future Development